代謝症候群危險因子探討

Background:Patients with metabolic syndrome are at high risk of cardiovascular diseases, diabetes, kidney disease, and high blood pressure. Five of the top ten leading causes of death in Taiwan are related to metabolic syndrome, which include cerebrovascular disease, heart disease, diabetes, nephropathy, and hypertension. The total mortality rate of these diseases has exceeded that of malignant tumors. This study aims to investigate the risk factors of metabolic syndrome.Methods: We conducted a cross-sectional case-control study in which we recruited subjects who came for health checkups at a medical center in Taichung City. From January 2006 to December 2006, a total of 1696 subjects were eligible for data analysis. According to 2005 NCEP ATP III standards, the subjects were divided into three groups: healthy group (those without anyone component of the metabolic syndrome), high-risk group (those with 1-2 components of the metabolic syndrome), and metabolic syndrome group (those with more than 3 components of the metabolic syndrome). The differences among groups were compared using analysis of variance and chi-square test, while the associations between metabolic syndrome and risk factors were estimated by multivariate logistic regression analysis.Results: The study came up with 358 subjects in the healthy group, 929 in the high-risk group, and 409 in metabolic syndrome group. The multivariate logistic regression analysis showed that age, gender, education level, SGOT, SGPT and uric acid were associated with increased risks of metabolic syndrome, whereas regular exercise habits and hepatitis B surface antigen positivity were associated with decreased ones.Conclusion: The results suggest that age, gender, education level, SGOT, SGPT, uric acid, exercise habits, as well as hepatitis B surface antigen are risk factors of metabolic syndrome.