β-Glucan, but not Lactobacillus plantarum P-8, inhibits lipid accumulation through selected lipid metabolic enzymes in obese rats

Hsiu Chuan Lee, Wei Ting Yu, Yu Ru Guo, Shih-Yi Huang

Research output: Contribution to journalArticle

Abstract

We compared the effects of barley β-glucan and Lactobacillus plantarum P-8 on changes in body weight, white adipose tissue, and the activities of specific lipid metabolic enzymes in diet-induced obese rats. Obese rats were administered barley β-glucan (B), L. plantarum P-8 (P), or both for 8 weeks. The results showed that the dietary intervention reduced the body weight and white adipose tissue accumulation, and altered gut microbiota in the distal faeces of the B group. Furthermore, acetate and propionate levels considerably increased in the caecal digest and rectal feces of the B group. In addition, β-glucan, but not L. plantarum P-8, increased the activities of hepatic acetyl CoA carboxylase, fatty acid synthase, and carnitine palmitoyl transferase and reduced epididymal fat lipoprotein lipase activity, thus resulting in decreased white adipose tissue accumulation in the obese rats. However, β-glucan and L. plantarum P-8 showed no synergistic effects. Practical applications: β-Glucan ameliorates hyperlipidaemia, increases hepatic acetyl CoA carboxylase, fatty acid synthase, and carnitine palmitoyl transferase activities, and reduces epididymal fat lipoprotein lipase activity, thus resulting in reduced white adipose tissue accumulation in obese rats. β-Glucan reduces of reducing lipid levels and regulating specific lipid metabolic enzymes.

Original languageEnglish
Article numbere12336
JournalJournal of Food Biochemistry
Volume41
Issue number1
DOIs
Publication statusPublished - Feb 1 2017

Fingerprint

Lactobacillus plantarum
Glucans
glucans
White Adipose Tissue
white adipose tissue
Lipids
rats
Enzymes
lipids
enzymes
carnitine palmitoyltransferase
Acetyl-CoA Carboxylase
Fatty Acid Synthases
acetyl-CoA carboxylase
fatty-acid synthase
lipoprotein lipase
Carnitine
Lipoprotein Lipase
Hordeum
Transferases

Keywords

  • Beta-glucan
  • Lactobacillus plantarum
  • Obesity
  • Short chain fatty acids

ASJC Scopus subject areas

  • Food Science
  • Biophysics
  • Pharmacology
  • Cell Biology

Cite this

β-Glucan, but not Lactobacillus plantarum P-8, inhibits lipid accumulation through selected lipid metabolic enzymes in obese rats. / Lee, Hsiu Chuan; Yu, Wei Ting; Guo, Yu Ru; Huang, Shih-Yi.

In: Journal of Food Biochemistry, Vol. 41, No. 1, e12336, 01.02.2017.

Research output: Contribution to journalArticle

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