β-Endorphin: Synthesis of analogs modified at the carboxyl terminus with increased activities

C. H. Li, D. Yamashiro, L. F. Tseng, W. C. Chang, P. Ferrara

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Three analogs of human β-endorphin (β(h)-EP) have been synthesized: [Gly 31]β(h)-EP, [Gly 31]β(h)-endorphinamide, and [Gly 31]β(h)-endorphinylglycine. All are more active than β(h)-EP in both the guinea pig ileum bioassay and the opiate receptor binding assay. The last two analogs are about twice as active as β(h)-EP in an assay for analgesia. Modification at position 31 and extension at the COOH terminus may afford a route toward analogs with even greater biological activity.

Original languageEnglish
Pages (from-to)3276-3278
Number of pages3
JournalProceedings of the National Academy of Sciences of the United States of America
Volume76
Issue number7
DOIs
Publication statusPublished - Dec 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • General

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