β-Endorphin: Deletion of a single amino acid residue abolishes immunoreactivity but retains opiate potency

Choh Hao Li, Wen Chang Chang, Donald Yamashiro, Liang Fu Tseng

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Two synthetic analogs of camel β-endorphin, one with omission of Leu-14 and the other with omission of Asn-20, have been assayed for immunoreactivity by radioimmunoassay, opiate activity in the guinea pig ileum preparation and analgesic potency in mice. It was found that the omission analogs had no immunoreactivity, but retained significant biological activities. As far as we are aware, this is the first instance in which deletion of a single amino acid residue in a biologically active peptide abolished immunoreactivity.

Original languageEnglish
Pages (from-to)693-697
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume87
Issue number3
DOIs
Publication statusPublished - Apr 13 1979
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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