β-胡蘿蔔素抑制長期攝食酒精之大白鼠肝臟脂肪堆積

Translated title of the contribution: β-carotene prevents hepatic lipid accumulation in rats under chronic alcohol consumption

Chi Chang Huang, Jiun-Rong Chen, Ti I. Huang, Ming-Che Hsieh, Jan-Show Chu, Suh-Ching Yang

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to investigate the effects of β-carotene on hypertriglycemia and alcoholic fatty liver in rats with chronic alcohol intake. Rats were divided into three groups: the control (C), ethanol (E), and ethanol with β-carotene (E + B) groups. After 10 weeks, results revealed that plasma GOT and GPT activities in group E were significantly higher than those in group C at weeks 6, 8, and 10, but they were significantly lower in group E + B compared to group E at week 10. Plasma total cholesterol (TC) levels in group E were significantly lower than those in the other groups at week 10. When compared to the plasma triglyceride (TG) concentration in group E, those of groups C and E + B were significantly lower at weeks 4, 6, 8, and 10. Furthermore, plasma HDL-C levels in group E + B were significantly higher, by 13%, than those in group E at week 10. On the other hand, the hepatic cholesterol and TG contents of group E were significantly higher, by 33% and 73%, respectively, than those in C group. However, hepatic cholesterol and TG contents in group E + B were significantly lower by 20% and 38%, respectively, compared to those in group E. β-carotene storage was detected in livers of E + B group, and the hepatic retinol content was significantly higher than those in groups C and E by 33% and 51%, respectively. Furthermore, the apparent accumulation of fat within hepatocytes was observed in the ethanol group. Results demonstrate that β-carotene supplementation can prevent alcoholic fatty liver formation by decreasing the plasma TG concentration, and inhibiting the accumulation of cholesterol and TG contents in the liver.

Translated title of the contributionβ-carotene prevents hepatic lipid accumulation in rats under chronic alcohol consumption
Original languageTraditional Chinese
Pages (from-to)129-138
Number of pages10
JournalNutritional Sciences Journal
Volume27
Issue number3
Publication statusPublished - Sep 2002

Keywords

  • β-carotene
  • Alcoholic fatty liver
  • Hypertriglycemia

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

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