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1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4 H -indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine

Chao, P. K., Ueng, S. H., Ou, L. C., Yeh, T. K., Chang, W. T., Chang, H. F., Chen, S. C., Tao, P. L., Law, P. Y., Loh, H. H., Cheng, M. F., Chuang, J. Y., Chen, C. T., Shih, C. & Yeh, S. H. May 1 2017 In : Anesthesiology. 126, 5, p. 952-966 15 p.

Research output: Contribution to journalArticle

Opioid Analgesics
Surgical Instruments
1 Citations

3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

Lee, H-Y., Lee, J. F., Kumar, S., Wu, Y. W., HuangFu, W-C., Lai, M-J., Li, Y-H., Huang, H. L., Kuo, F. C., Hsiao, C. J., Cheng, C. C., Yang, C. R. & Liou, J-P. Jan 5 2017 In : European Journal of Medicinal Chemistry. 125, p. 1268-1278 11 p.

Research output: Contribution to journalArticle

Histone Deacetylases
In Vitro Techniques
Hydroxamic Acids

4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo

Mehndiratta, S., Wang, R. S., Huang, H. L., Su, C. J., Hsu, C. M., Wu, Y. W., Pan, S. L. & Liou, J. P. Jul 7 2017 In : European Journal of Medicinal Chemistry. 134, p. 13-23 11 p.

Research output: Contribution to journalArticle

In Vitro Techniques
Histone Deacetylase Inhibitors

500-Gray γ-Irradiation May Increase Adhesion Strength of Lyophilized Cadaveric Split-Thickness Skin Graft to Wound Bed

Wei, L. G., Chen, C. F., Wang, C. H., Cheng, Y. C., Li, C. C., Chiu, W. K. & Wang, H. J. Feb 3 2017 In : Annals of Plastic Surgery.

Research output: Contribution to journalArticle

Wounds and Injuries
Freeze Drying

A case-control study of the association between ulcerative colitis and hyperthyroidism in an Asian population

Tsai, M. C., Lin, H. C. & Lee, C. Z. Jun 1 2017 In : Clinical Endocrinology. 86, 6, p. 825-829 5 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Case-Control Studies
Odds Ratio
Confidence Intervals

A Case Report of Transient Cortical Blindness after Angiography

Chen, C. Y., Chen, C. J. & Tseng, Y. C. 2017 In : Neurologist. 22, 3, p. 82-84 3 p.

Research output: Contribution to journalArticle

Cortical Blindness
Magnetic Resonance Spectroscopy
Vertebral Artery Dissection
Mitogen-Activated Protein Kinases
Heart Atria
Histone Acetyltransferases
Aortic Valve
Alkaline Phosphatase

Active gellan gum/purple sweet potato composite films capable of monitoring pH variations

Wei, Y. C., Cheng, C. H., Ho, Y. C., Tsai, M. L. & Mi, F. L. Aug 1 2017 In : Food Hydrocolloids. 69, p. 491-502 12 p.

Research output: Contribution to journalArticle

Composite films
Ipomoea batatas

Acupressure, Sleep, and Quality of Life in Institutionalized Older Adults: A Randomized Controlled Trial

Lai, F. C., Chen, I. H., Chen, P. J., Chen, I. J., Chien, H. W. & Yuan, C. F. 2017 In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticle

Quality of Life
Nursing Homes
Acupuncture Points

Acute hospital administration of amiodarone and/or lidocaine in shockable patients presenting with out-of-hospital cardiac arrest: A nationwide cohort study

Huang, C. H., Yu, P. H., Tsai, M. S., Chuang, P. Y., Wang, T. D., Chiang, C. Y., Chang, W. T., Ma, M. H. M., Tang, C. H. & Chen, W. J. Jan 15 2017 In : International Journal of Cardiology. 227, p. 292-298 7 p.

Research output: Contribution to journalArticle

Hospital Administration
Out-of-Hospital Cardiac Arrest
Heart Arrest

Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate

Huang, C. K., Chang, P. H., Kuo, W. H., Chen, C. L., Jeng, Y. M., Chang, K. J., Shew, J. Y., Hu, C. M. & Lee, W. H. Mar 10 2017 In : Nature Communications. 8, 14706

Research output: Contribution to journalArticle

3-Hydroxybutyric Acid
Breast Neoplasms

Adverse neonatal outcomes in relation to ambient temperatures at birth: A nationwide survey in Taiwan

Weng, Y. H., Yang, C. Y. & Chiu, Y. W. Apr 18 2017 In : Archives of Environmental and Occupational Health. p. 1-8 8 p.

Research output: Contribution to journalArticle

Premature Birth
Low Birth Weight Infant
1 Citations

A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer

Shieh, J. M., Tang, Y. A., Hu, F. H., Huang, W. J., Wang, Y. J., Jen, J., Liao, S. Y., Lu, Y. H., Yeh, Y. L., Wang, T. W., Lin, P. & Wang, Y. C. May 15 2017 In : International Journal of Cancer. 140, 10, p. 2375-2386 12 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Histone Deacetylase Inhibitors
Histone Deacetylases
Non-Small Cell Lung Carcinoma

A hybrid session key exchange algorithm for highly-sensitive IP-based institutional communications

Zhuang, Z. Y., Hsu, Y. C., Nurmi, K., Chen, Y. C., Liu, H. H. & Tseng, T. S. Jan 28 2017 In : Microsystem Technologies. p. 1-11 11 p.

Research output: Contribution to journalArticle

Secure communication
Electronic document identification systems
Security of data

Alirocumab for the treatment of hypercholesterolemia

Tomlinson, B., Hu, M., Zhang, Y., Chan, P. & Liu, Z. M. Mar 20 2017 In : Expert Opinion on Biological Therapy. p. 1-11 11 p.

Research output: Contribution to journalArticle

LDL Cholesterol
Proprotein Convertases

Allopurinol, benzbromarone and risk of coronary heart disease in gout patients: A population-based study

Lin, H. C., Daimon, M., Wang, C. H., Ho, Y., Uang, Y. S., Chiang, S. J. & Wang, L. H. Apr 15 2017 In : International Journal of Cardiology. 233, p. 85-90 6 p.

Research output: Contribution to journalArticle

Coronary Disease
Coronary Artery Disease
1 Citations

A low molecular mass organogelator electrolyte with TiO2 nanoparticles for stable and efficient quasi-solid-state dye sensitized solar cells

Girma, W. M., Chen, C. H., Yang, C. H., Wang, P. I., Ou, K. L., Liaw, D. J. & Chang, J. Y. 2017 In : RSC Advances. 7, 13, p. 7671-7678 8 p.

Research output: Contribution to journalArticle

Molecular mass
Composite materials

Alpinia oxyphylla Miq. fruit extract activates IGFR-PI3K/Akt signaling to induce Schwann cell proliferation and sciatic nerve regeneration

Chang, Y. M., Chang, H. H., Tsai, C. C., Lin, H. J., Ho, T. J., Ye, C. X., Chiu, P. L., Chen, Y. S., Chen, R. J., Huang, C. Y. & Lin, C. C. Mar 31 2017 In : BMC Complementary and Alternative Medicine. 17, 1, 184

Research output: Contribution to journalArticle

Nerve Regeneration
Schwann Cells
Sciatic Nerve
Phosphatidylinositol 3-Kinases

A MicroRNA302-367-Erk1/2-Klf2-S1pr1 Pathway Prevents Tumor Growth via Restricting Angiogenesis and Improving Vascular Stability

Pi, J., Tao, T., Zhuang, T., Sun, H., Chen, X., Liu, J., Cheng, Y., Yu, Z., Zhu, H. H., Gao, W. Q., Suo, Y., Wei, X., Chan, P., Zheng, X., Tian, Y., Morrisey, E., Zhang, L. & Zhang, Y. Jan 6 2017 In : Circulation Research. 120, 1, p. 85-98 14 p.

Research output: Contribution to journalArticle

Blood Vessels
Endothelial Cells
Pathologic Neovascularization

A multidisciplinary team care approach improves outcomes in high-risk pediatric neuroblastoma patients

Chang, H. H., Liu, Y. L., Lu, M. Y., Jou, S. T., Yang, Y. L., Lin, D. T., Lin, K. H., Tzen, K. Y., Yen, R. F., Lu, C. C., Liu, C. J., Peng, S. S. F., Jeng, Y. M., Huang, S. F., Lee, H., Juan, H. F., Huang, C. M., Liao, Y. F., Lee, Y. L. & Hsu, W. M. 2017 In : Oncotarget. 8, 3, p. 4360-4372 13 p.

Research output: Contribution to journalArticle

Disease-Free Survival
Case Management

Analysis of the effects of individual and community level factors on childhood immunization in Malawi

Ntenda, P. A. M., Chuang, K. Y., Tiruneh, F. N. & Chuang, Y. C. Apr 4 2017 In : Vaccine. 35, 15, p. 1907-1917 11 p.

Research output: Contribution to journalArticle


An apple a day to prevent cancer formation: Reducing cancer risk with flavonoids

Tu, S-H., Chen, L-C. & Ho, Y-S. Jan 1 2017 In : Journal of Food and Drug Analysis. 25, 1, p. 119-124 6 p.

Research output: Contribution to journalReview article

Insurance Benefits
Blood Vessels

A New Comprehensive Short-form Health Literacy Survey Tool for Patients in General

Duong, T. V., Chang, P. W. S., Yang, S. H., Chen, M. C., Chao, W. T., Chen, T., Chiao, P. & Huang, H. L. Mar 1 2017 In : Asian Nursing Research. 11, 1, p. 30-35 6 p.

Research output: Contribution to journalArticle

Health Literacy
Health Surveys
Health Promotion
Linear Models

A New Form of Artificial Skin to Promote Permanent Wound Coverage: A Preliminary Report

Wang, H. J., Wei, L. G., Wang, C. H., Cheng, Y. C., Chang, J. L., Tsou, T. L., Ku, C. H., Li, C. C., Chiu, W. K. & Chen, C. F. Jan 27 2017 In : Annals of Plastic Surgery.

Research output: Contribution to journalArticle

Artificial Skin
Wounds and Injuries
Acellular Dermis
1 Citations

Angiomotin regulates prostate cancer cell proliferation by signaling through the Hippo-YAP pathway

Zeng, H., Ortiz, A., Shen, P. F., Cheng, C. J., Lee, Y. C., Yu, G., Lin, S. C., Creighton, C. J., Yu-Lee, L. Y. & Lin, S. H. 2017 In : Oncotarget. 8, 6, p. 10145-10160 16 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Cell Proliferation
Long-Acting Thyroid Stimulator
Neurofibromin 2

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells

Chao, M. W., Huang, H. L., HuangFu, W. C., Hsu, K. C., Liu, Y. M., Wu, Y. W., Lin, C. F., Chen, Y. L., Lai, M. J., Lee, H. Y., Liou, J. P., Teng, C. M. & Yang, C. R. 2017 In : Oncotarget. 8, 17, p. 27772-27785 14 p.

Research output: Contribution to journalArticle

National Cancer Institute (U.S.)
JNK Mitogen-Activated Protein Kinases

Anorectal complications after robotic intersphincteric resection for low rectal cancer

Kuo, L. J., Ngu, J. C. Y., Huang, Y. J., Lin, Y. K., Chen, C. C., Tong, Y. S., Huang, S. C., Hu, C. C. & Tan, S. H. Apr 3 2017 In : Surgical Endoscopy and Other Interventional Techniques. p. 1-6 6 p.

Research output: Contribution to journalArticle

Rectal Neoplasms
Ambulatory Surgical Procedures
Pathologic Constriction

A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice

Sheu, J. R., Chen, Z. C., Jayakumar, T., Chou, D. S., Yen, T. L., Lee, H. N., Pan, S. H., Hsia, C. H., Yang, C. H. & Hsieh, C. Y. Feb 6 2017 In : Scientific Reports. 7, 42277

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
JNK Mitogen-Activated Protein Kinases

Antibacterial of silver-containing polydimethylsiloxane urethane nanofibrous, hollow fibrous, using the electrospinning process

Huang, C. C., Rwei, S. P., Jang, C. S., Tsen, W. C., Chuang, F. S., Ku, T. H., Chow, J. D., Chen, C-C. & Shu, Y. C. Mar 1 2017 In : Journal of Nanoscience and Nanotechnology. 17, 3, p. 1975-1982 8 p.

Research output: Contribution to journalArticle

Fibrous membranes
4 Citations

Antidepressant-like effects of long-term sarcosine treatment in rats with or without chronic unpredictable stress

Chen, K. T., Wu, C. H., Tsai, M. H., Wu, Y. C., Jou, M. J., Huang, C. C. & Wei, I. H. Jan 1 2017 In : Behavioural Brain Research. 316, p. 1-10 10 p.

Research output: Contribution to journalArticle

Antidepressive Agents

Anti-inflammatory properties of shikonin contribute to improved early-stage diabetic retinopathy

Liao, P. L., Lin, C. H., Li, C. H., Tsai, C. H., Ho, J. D., Chiou, G. C. Y., Kang, J. J. & Cheng, Y. W. Mar 21 2017 In : Scientific Reports. 7, 44985

Research output: Contribution to journalArticle

Diabetic Retinopathy
Anti-Inflammatory Agents
Mitochondrial Dynamics
Estrogen Receptors
Neoplasm Metastasis

Antimuscarinic Use in Females With Overactive Bladder Syndrome Increases the Risk of Depressive Disorder: A 3-Year Follow-up Study

Chung, S. D., Weng, S. S., Huang, C. Y., Lin, H. C. & Kao, L. T. 2017 In : Journal of Clinical Pharmacology.

Research output: Contribution to journalArticle

Overactive Urinary Bladder
Muscarinic Antagonists
Depressive Disorder
Confidence Intervals
Cohort Studies

Antiseptic Effect of Conventional Povidone-Iodine Scrub, Chlorhexidine Scrub, and Waterless Hand Rub in a Surgical Room: A Randomized Controlled Trial

Tsai, J. C., Lin, Y. K., Huang, Y. J., Loh, E. W., Wen, H. Y., Wang, C. H., Tsai, Y. T., Hsieh, W. S. & Tam, K. W. Apr 1 2017 In : Infection Control and Hospital Epidemiology. 38, 4, p. 417-422 6 p.

Research output: Contribution to journalArticle

Local Anti-Infective Agents
Randomized Controlled Trials
Stem Cells
Neoplastic Stem Cells
beta Catenin

A personalized medication management platform (PMMP) to improve medication adherence: A randomized control trial

Huang, C. Y., Nguyen, P. A. A., Clinciu, D. L., Hsu, C. K., Lu, J. C. R., Yang, H. C., Wu, C. C., Tsai, W. C., Chou, Y. C., Kuo, T. B. J., Chang, P. L., Jian, W. S. & Li, Y. C. J. Mar 1 2017 In : Computer Methods and Programs in Biomedicine. 140, p. 275-281 7 p.

Research output: Contribution to journalArticle

Medication Adherence
Costs and Cost Analysis
Breast Neoplasms
Single Nucleotide Polymorphism
Genome-Wide Association Study
Area Under Curve

Application of Intraoperative CT-Guided Navigation in Simultaneous Minimally Invasive Anterior and Posterior Surgery for Infectious Spondylitis

Wu, M. H., Dubey, N. K., Lee, C. Y., Li, Y. Y., Cheng, C. C., Shi, C. S. & Huang, T. J. 2017 In : BioMed Research International. 2017, 2302395

Research output: Contribution to journalArticle

Pedicle Screws
Blood Sedimentation
Back Pain
Cell adhesion
Cell proliferation

A proof-of-principle simulation for closed-loop control based on preexisting experimental thalamic DBS-enhanced instrumental learning

Wang, C. F., Yang, S-H., Lin, S. H., Chen, P. C., Lo, Y. C., Pan, H. C., Lai, H. Y., Liao, L. D., Lin, C. H., Chen, H. Y., Huang, W. C., Huang, W. J. & Chen, Y. Y. May 1 2017 In : Brain Stimulation. 10, 3, p. 672-683 12 p.

Research output: Contribution to journalArticle

Operant Conditioning
Deep Brain Stimulation
Power (Psychology)
Intralaminar Thalamic Nuclei

AR-12 suppresses dengue virus replication by down-regulation of PI3K/AKT and GRP78

Chen, H., Chen, C. C., Lin, Y. S., Chang, P. C., Lu, Z. Y., Lin, C. F., Chen, C. L. & Chang, C. P. Jun 1 2017 In : Antiviral Research. 142, p. 158-168 11 p.

Research output: Contribution to journalArticle

Dengue Virus
Virus Replication
Phosphatidylinositol 3-Kinases

Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells

Tsai, M. H., Liu, J. F., Chiang, Y. C., Hu, S. C. S., Hsu, L. F., Lin, Y. C., Lin, Z. C., Lee, H. C., Chen, M. C., Huang, C. L. & Lee, C. W. 2017 In : Oncotarget. 8, 17, p. 28342-28358 17 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Protein Kinases
Reactive Oxygen Species

Assessing utility of exercise test in determining exercise prescription in adolescent and adult patients with repaired tetralogy of fallot

Yang, M. C., Chen, C. A., Chiu, H. H., Wang, J. K., Lin, M. T., Chiu, S. N., Lu, C. W., Huang, S. C. & Wu, M. H. Feb 1 2017 In : Heart and Vessels. 32, 2, p. 201-207 7 p.

Research output: Contribution to journalArticle

Tetralogy of Fallot
Exercise Test

Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

Seow, W. J. , Matsuo, K. , Hsiung, C. A. , Shiraishi, K. , Song, M. , NamKim, H. , Wong, M. P. , Hong, Y. C. , Dean Hosgood, H. , Wang, Z. , Chang, I. S. , Wang, J. C. , Chatterjee, N. , Tucker, M. , Wei, H. , Mitsudomi, T. , Zheng, W. , Kim, J. H. , Zhou, B. , Caporaso, N. E. & 166 others Albanes, D., Shin, M. H., Chung, L. P., An, S. J., Wang, Y. P., Zheng, H., Yatabe, Y., Zhang, X. C., Kim, Y. T., Shu, X. O., Kim, Y. C., Bassig, B. A., Chang, J., Man Ho, J. C., Ji, B. T., Kubo, M., Daigo, Y., Ito, H., Momozawa, Y., Ashikawa, K., Kamatani, Y., Honda, T., Sakamoto, H., Kunitoh, H., Tsuta, K., Watanabe, S. I., Nokihara, H., Miyagi, Y., Nakayama, H., Matsumoto, S., Tsuboi, M., Goto, K., Yin, Z., Shi, J., Takahashi, A., Goto, A., Minamiya, Y., Shimizu, K., Tanaka, K., Wu, T., Wei, F., Wong, J. Y. Y., Matsuda, F., Su, J., Kim, Y. H., Oh, I. J., Song, F., Lee, V. H. F., Su, W. C., Chen, Y. M., Chang, G. C., Chen, K. Y., Huang, M. S., Yang, P. C., Lin, H. C., Xiang, Y. B., Seow, A., Park, J. Y., Kweon, S. S., Chen, C. J., Li, H., Gao, Y. T., Wu, C., Qian, B., Lu, D., Liu, J., Jeon, H. S., Hsiao, C. F., Sung, J. S., Tsai, Y. H., Jung, Y. J., Guo, H., Hu, Z., Wang, W. C., Chung, C. C., Lawrence, C., Burdett, L., Yeager, M., Jacobs, K. B., Hutchinson, A., Berndt, S. I., He, X., Wu, W., Wang, J., Li, Y., Choi, J. E., Park, K. H., Sung, S. W., Liu, L., Kang, C. H., Hu, L., Chen, C. H., Yang, T. Y., Xu, J., Guan, P., Tan, W., Wang, C. L., Loon Sihoe, A. D., Chen, Y., Choi, Y. Y., Hung, J. Y., Kim, J. S., Yoon, H. I., Cai, Q., Lin, C. C., Park, I. K., Xu, P., Dong, J., Kim, C., He, Q., Perng, R. P., Chen, C. Y., Vermeulen, R., Wu, J., Lim, W. Y., Chen, K. C., Chan, J. K. C., Chu, M., Li, Y. J., Li, J., Chen, H., Yu, C. J., Jin, L., Lo, Y. L., Chen, Y. H., Fraumeni, J. F., Liu, J., Yamaji, T., Yang, Y., Hicks, B., Wyatt, K., Li, S. A., Dai, J., Ma, H., Jin, G., Song, B., Wang, Z., Cheng, S., Li, X., Ren, Y., Cui, P., Iwasaki, M., Shimazu, T., Tsugane, S., Zhu, J., Jiang, G., Fei, K., Wu, G., Chien, L. H., Chen, H. L., Su, Y. C., Tsai, F. Y., Chen, Y. S., Yu, J., Stevens, V. L., Laird-Offringa, I. A., Marconett, C. N., Lin, D., Chen, K., Wu, Y. L., Landi, M. T., Shen, H., Rothman, N., Kohno, T., Chanock, S. J. & Lan, Q. 2017 In : Human Molecular Genetics. 26, 2, p. 454-465 12 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Carpal Tunnel Syndrome
Neural Conduction
Ulnar Nerve
Median Nerve

Association between open-angle glaucoma and neovascular age-related macular degeneration: a case-control study

Hu, C. C., Ho, J-D., Lin, H-C. & Kao, L. T. Feb 10 2017 In : Eye.

Research output: Contribution to journalArticle

Open Angle Glaucoma
Macular Degeneration
Case-Control Studies
Odds Ratio

Association of blood heavy metals with developmental delays and health status in children

Hsueh, Y. M., Lee, C. Y., Chien, S. N., Chen, W. J., Shiue, H. S., Huang, S. R., Lin, M. I., Mu, S. C. & Hsieh, R. L. Mar 2 2017 In : Scientific Reports. 7, 43608

Research output: Contribution to journalArticle

Heavy Metals
Health Status
Quality of Life

Associations of estradiol levels and genetic polymorphisms of inflammatory genes with the risk of ischemic stroke

Hsieh, Y. C., Hsieh, F. I., Chen, Y. R., Hu, C. J., Jeng, J. S., Tang, S. C., Chi, N. F., Lin, H. J., Lien, L. M., Peng, G. S. & Chiou, H. Y. Mar 28 2017 In : Journal of Biomedical Science. 24, 1, 25

Research output: Contribution to journalArticle

Confidence Intervals
Neuroprotective Agents

Asthma, corticosteroid use and schizophrenia: A nationwide populationbased study in Taiwan

Wang, W. C., Lu, M. L., Chen, V. C. H., Ng, M. H., Huang, K. Y., Hsieh, M. H., Hsieh, M. J., Mcintyre, R. S., Lee, Y. & Lee, C. T. C. Mar 1 2017 In : PLoS ONE. 12, 3, e0173063

Research output: Contribution to journalArticle

Adrenal Cortex Hormones
International Classification of Diseases