To Verify Cd44 and Arpc2 Expressions in Gbm of Different Brain Lobes via Tissue Array Identifies Cd44/Arpc2 Regulate Radioresistance and Radiomics of Gbm in Different Brain Lobes to Build up Radiogenomics and Develop Ai for Personally Precise Medicine.

Project: A - Government Institutionb - Ministry of Science and Technology

Project Details

Description

多形性神經膠質母細胞瘤(GBM)是最具侵襲性的原發腦癌。本研究致力於分析CD44/ARPC2表現量與GBM放射線抗性、細胞移動能力、癌幹細胞特性的關係,鑑別放射治療抗性GBM的影像特質,合併CD44/ARPC2組織染色狀況,利用實驗結果,建立基因資料庫合併Watson for Genomics 讓分子病理學實驗室擴充其精準腫瘤計劃,以滿足個人化癌症照顧,篩選需放射治療早期合併Anti-CD44 Therapeutic Antibody (Bivatuzumab)、Anti-ARPC2 agent (Pimozide)藥物治療,達成減少健保支出及降低社會成本,使病患及家屬能重返職場促進經濟發展。
StatusActive
Effective start/end date8/1/227/31/23

Keywords

  • Glioblastoma multiforme (GBM)
  • CD44
  • radioresistance
  • cancer stem cell properties
  • ARPC2
  • Radiogenomics
  • Artificial Intelligence (AI)