Decoction is one formulation of traditional Chinese medicines. Following the advancement of pharmaceutical technology, the concentrated herbal extracts became popular since 1963. However, few studies had reported the bioequivalence between the decoction and concentrated herbal extracts. Thus, we choose the Si-Wu Tang (SWT), the widely used traditional Chinese prescription, as our target to explore the bioequivalence differences. SWT can be used as the food supplement or drug usage. Health people usually used SWT to treat or prevent anemia, so we can employed SWT to monitor the human bioequivalence effects. Traditional Chinese medical doctor usually used SWT to treat the patients who are diagnosed as ovarian follicular maldevelopment, so SWT can be used to evaluate the pharmacological bioequivalence. Taken together, SWT is the most suitable prescription to explore the bioequivalence between the decoction and concentrated herbal extracts. This study has two topics. First topic: explore the bioequivalence effects of SWT which are presented as decoction or concentrated herbal extracts forms in different age health women. Second topic: explore the pharmacological bioequivalence of different forms of SWT in ovarian follicular maldevelopment patients. In this study, we can establish the correlations between the dose-usage and decoction and concentrated herbal extracts. Our results are useful for people’s usage and the clinical applications of traditional Chinese medical doctors and pharmaceutical industry and
|Effective start/end date||11/19/10 → 11/20/11|
- Si-Wu Tang
- concentrated herbal extracts
- ovarian follicular maldevelopment
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