Targeting Calcium Dysregulation, Mitochondrial Disorder, and Inflammasome Signaling of Nlr Family Pyrin Domain Containing 3 (Nlrp3) /Macrophage Migration Inhibitory Factor (Mif) in Autoimmune Myocarditis-Induced Ventricular Arrhythmogenesis

Project: A - Government Institutionb - Ministry of Science and Technology

Project Details

Description

自體免疫引發心肌炎會引起心室心律不整,並降低病人存活率與增加醫療負擔,健保資料庫顯示心肌炎患者耗費巨額費用。自體免疫之發炎反應則是引發心肌炎重要因子。本計畫將研究NLRP3/MIF訊息路徑於自體免疫與心室心律不整關係;分析改變NLRP3/TLR4/CD74路徑是否能應用於心肌炎治療。本研究將增加對於自體免疫引發心肌炎之心室心律不整病理機轉了解,並對社會、經濟、基礎醫學研究與臨床治療之發展殊為重要。
StatusActive
Effective start/end date8/1/227/31/23

Keywords

  • Myocarditis
  • Autoimmune
  • NLRP3 inflammasome
  • MIF
  • RVOT