Rescuing Chemotherapy-Induced Epigenetic Alterations in Cancer Fibroblasts as a Novel Therapeutic Strategy in Advanced Pancreatic Ductal Adenocarcinoma (1/3)

Project: A - Government Institutionb - Ministry of Science and Technology

Project Details

Description

胰臟癌是致死率最高的癌症,傳統化學治療僅有有限效益。本團隊發現化學治療會誘發胰臟癌基質中成纖維細胞中特定組蛋白去乙烯酶的蛋白分解,促使其釋放眾多促腫瘤細胞激素。若避免此治療有發之腫瘤基質變化可以明顯增進胰臟癌的治療效果。此研究提供新穎的”基質拯救”胰臟癌治療新途徑,可與臨床試驗接軌,具高度學術與應用價值。
StatusActive
Effective start/end date8/1/227/31/23

Keywords

  • pancreatic ductal adenocarcinoma
  • chemotherapy
  • tumor stroma
  • carcinoma-associated fibroblasts
  • histone deacetylase