Both oxidative stress and endocrine-disrupting chemicals (EDCs) had been associated with polycystic ovary syndrome (PCOS). Bisphenol A (BPA), one of EDCs, is an environmental estrogen used in the synthesis of plastics, is a "high-volume production" chemical with widespread human exposure. BPA was been reported in several female reproductive disturbance. However, the pathological pathway of BPA impact on female reproductive system had not been well-understood. Reactive oxygen species (ROS) have a role in the modulation of gamete quality and gamete interaction. Persistent and elevated generation of ROS leads to a disturbance of redox potential that in turn causes oxidative stress (OS). The first part of our study is aim to evaluate the oxidative stress impact on the biochemical parameters in women with PCOS; the secondary part of our study is to investigate the BPA on the clinical and biochemical of women with PCOS; finally, we plan to test the hypothesis that BPA might increase oxidative stress and then elevated ROS in women with menstrual disturbance, furthermore, the role of antioxidant treatment impact on reproductive disturbance will be also investigated.
|Effective start/end date||8/1/12 → 7/31/13|
- endocrine-disrupting chemicals
- Bisphenol A
- Reactive oxygen species
- oxidative stress