Successful osseointegration depends on the achievement of primary implant stability. Resonance frequency analysis (RFA) has been used for dental implant stability detection for years. However, studies have shown that high RF values at the initial stages do not guarantee a 100% success rate of dental implants. This is because RF values can provide useful information on stability at the marginal cortical area. However, RF analysis provides little information on healing status of the trabecular bone and soft tissue at the deep implant/bone interface. Damping factor (DF) is a dimensionless measure describing how oscillations of a structure decay after a disturbance, has been regarded as a noninvasive method to assess bone structure integrity and to monitor the changes of bone properties. However no study used DF as a parameter to evaluate the status of soft tissue and immature bone around dental implant. The aim of this study proposal is to evaluate whether resonance frequency analysis (RFA) combined with damping factor (DF) analysis provides additional information on dental implant healing status. In this study proposal, in vivo animal experiments were performed. Dental implants will be placed into the tibia of rabbits. The RF and DF values of the implants will be measured during the entire healing process. Implant stability quotient (ISQ) and Periotest value (PTV) obtained from Osstell and Periotest were used to validate the apparatus. In the in vivo experiments, vibrational analysis was performed on dental implants in 40 rabbits. The quantitation of osseointegration will be performed by micro CT and histological analysis. RF and DF values of the tested implants were recorded during the first eight weeks post-surgery. This new non-invasive and non-destructive diagnosis technique for detecting the boundary conditions of dental implants will be assessed and compared with traditional examination methods. These data may then be used as an important reference for future advanced experiments.
|Effective start/end date||8/1/14 → 7/31/15|