Down-Regulation of Mir-1, Mir-133a, and Let-7c Reduces to Control Gp130-Il-6 Signaling, a Novel Role to Promote Inflammaging in Copd (2/3)

Project: A - Government Institutionb - Ministry of Science and Technology

Project Details

Description

慢性阻塞性肺病為嚴重發病率和死亡率的呼吸道疾病,造成健保資源重大負擔。除了吸菸之外,近年不斷惡化的空氣汙染亦可能是致病成因,遺憾目前尚無有效療法。慢性阻塞性肺病是一種發炎老化肺病,IL-6-gp130-STAT3信號路徑於調控發炎老化過程具有重要意義,然而在慢性阻塞性肺病上游控制IL-6-gp130-STAT3信號的分子機制尚不明確。本計畫研究特定微RNA抑制gp130的新機制,試圖進一步釐清慢性阻塞性肺病致病成因,希望能提供針對IL-6-gp130-STAT3路徑更精準的藥物開發。
StatusActive
Effective start/end date8/1/227/31/23

Keywords

  • COPD
  • senescence
  • inflammaing
  • IL-6
  • GP130
  • STAT3
  • miR-1
  • miR-133
  • let-7c
  • Prothymosin (ProT)