Development of Novel Mannose-Functionalized Covid-19 Virus-Mimicking Nanoparticles (Vmns) to Elicit Durable Antibodies and Cellular Immunity

Project: A - Government Institutionb - Ministry of Science and Technology

Project Details

Description

本計畫預期製備出具有高免疫原性之甘露糖修飾COVID-19 仿病毒奈米顆粒,改善蛋白質型疫苗的缺點,提升免疫抗原性,提升疫苗長期記憶免疫效力,並將不同變種多價的棘狀蛋白將修飾於奈米顆粒表現,因而引起多重免疫反應以同時對抗不同變種COVID-19,藉此促進國內疫苗開發瓶頸,並提供業界之次世代疫苗技術平台,以提升生技醫藥研發自主性與疫苗國造的能力,迅速應變未來可能的疫情。
StatusActive
Effective start/end date8/1/227/31/23

Keywords

  • COVID-19
  • vaccines
  • nanoparticles
  • protein-based vaccines
  • mannose-functionalized
  • virus-mimicking nanoparticles