Development of Human Diffuse Large B-Cell Lymphoma Targeted Therapy through Genome-Wide Crispr Screening Library Platform

Project: A - Government Institutionb - Ministry of Science and Technology

Project Details

Description

在先前研究中計畫申請人研究團隊已完成數項重要研究目標,確認DLBCL維持惡性度最重要的基因群、建立完整HDAC家族knockout DLBCL細胞株、臨床研究找出MYC/BCL6是台灣雙打擊DLBCL頻率最高的組合。本計畫將進一步建立DLBCL分子動態結合模型分析與動態蛋白質交互作用網路,並以小分子藥物結合位相發展前導標靶藥物,開發臨床DLBCL有效抗癌策略,以解決雙打擊DLBCL此類高侵襲性癌症病患低存活率的議題。
StatusActive
Effective start/end date8/1/227/31/23

Keywords

  • CRISPR screening library research
  • diffuse large B-cell lymphoma
  • patient-derived cancer/xenograft
  • gene editing
  • biomarker
  • dynamic protein interaction network