One neuronal precondition for attentional amplification is the fast, efficient interconnection of distant brain regions. Glutamatergic abnormalities can sometimes interfere with this fluid interconnectedness. In this regard the Global Neuronal Workspace and the Glutamatergic hypotheses of schizophrenia intersect. In order to better understand the relationship between these two and how glutamatergic abnormalities impede attentional amplification, we are using MRS to measure glutamate in regions that are crucial to adequate amplification. Moreover, because spontaneous, intrinsic activity can also interfere with attentional amplification, we are conducting rsMRI on the fronto-parietal and other networks. And, in order to link regional with temporal changes (as measured by EEG/ERP), we employ the visual masking task while patients undergo fMRI. Finally, data concerning regional activity—spontaneous and task-related—can be applied to refinement of the tACS, clinical trial protocol.
|Effective start/end date||8/1/20 → 7/1/21|
- Glutamatergic Hypothesis of Schizophrenia
- Global Neuronal Workspace Hypothesis of Schizophrenia
- masking task
- attentional amplification
- fronto-parietal network