Apply Human Cell Lines and Mice Model to Study Novel Bio-Adhesive Nanomaterials in Anti-Aging and Skin Cancer Prevention.

Project: A - Government Institutionb - Ministry of Science and Technology

Project Details

Description

The existence of the reactive oxygen species (ROS) is one of the main factors that result in aging of skin cells and even cancer. Over-exposure to UV radiation could increase ROS levels and lead to skin diseases or induce the transformation of skin cells, and therefore anti-UV radiation and anti-oxidation are critical in the cosmetic research fields. Various inorganic nanomaterials such as CeO2, ZnO and TiO2 are extensively used to protect against the UV radiation, however, with the photocatalytic properties, these materials could generate free radicals under certain conditions, which is a safety concern when apply on human skin. On the other hand, reduced graphene oxide has great UV absorption capacity, and fullerene also exhibits ROS absorption capacity, and they can reduce free radical levels produced from metabolite or ectopic stimuli. We hypothesize that conjugation of whether graphene or fullerene onto TiO2 could keep the advantage of anti-UV and reduce the potential hazardous of free radical, and broaden the future biomedical application of this composite. Our preliminary data on fullerene suggested that our composites exhibited protection effect towards human cells, and part of the anti-free radical and anti-inflammation results have just been published in the international journal RSC Advance. We plan to further functionalized TiO2 with graphene, C60, or C70, and investigate their anti-UV and anti-inflammation effect in cell lines and in mice model. We will also prepare the composites as a bio-adhesive hydrogel form, to strengthen the biocompatibility and the skin protection of the nanomaterial, and broaden its future anti-aging biomedical applications.
StatusFinished
Effective start/end date8/1/177/31/18

Keywords

  • Bio-adhesive nanomaterials
  • TiO2
  • reduced graphene oxide
  • fullerene
  • anti-free radical
  • anti-inflammation
  • anti-aging