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  The Biological Mechanisms of N-3 Polyunsaturated Fatty Acid Treatment in Interferon-Induced Depression

  Huang, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 睡眠困擾是癌症病人最常主訴的問題之一。患有睡眠困擾之癌症病人經常同時伴隨 疲憊、憂鬱等現象發生，形成症狀群集，影響生活品質。雖然目前對於癌症病人睡眠障 礙之量性研究已多有著墨，然而對於癌症病人經歷睡眠障礙之主觀經驗之瞭解，仍相當 有限。瞭解病人經歷睡眠障礙之主觀經驗，將有助於未來睡眠評估工具之修訂。另外， 在評估癌症病人睡眠品質時，若能以簡單工具評估，會更具效率及助益。阿森斯失眠量 表(Athens Insomnia Scale, AIS) 是一個簡單的8 題問卷，廣為使用在一般失眠的病人， 在癌症病人使用上，尚未有豐富的實證資料，若能建立其在癌症病人的信效度，將可作 為一簡單篩檢癌症病人失眠的工具。 睡眠遵行日夜節律規則，日夜節律又需要光作為矯正的線索，光在癌症病人睡眠的 角色，尚未有研究證實，過去研究顯示癌症病人睡眠品質不佳與生物節律有關係。光是 重要日夜節律的線索，光療法透過褪黑激素調節，調整日夜節律週期，可能可以改善睡 眠品質。另外，由於，睡眠障礙、憂鬱、疲憊經常形成一症狀群集，光療法於改善睡眠 障礙之同時，是否亦同時改善憂鬱、疲憊及生活品質。目前，光療法在癌症病人的運用 上，付之闕如，故建立光療法於癌症病人的有效性值得探究。 本研究為三年期研究計畫，目的包括有：1.瞭解癌症個案對於睡眠困擾的主觀經驗 （第一年）。2.建立阿森斯失眠量表中文版的信效度、敏感性、特異性（第一年）。3.瞭 解癌症病人光暴露與生物節率、睡眠障礙的關係（第二年）。4.瞭解光療法對於改善癌 症病人睡眠障礙及相關症狀群集、及生活品質之成效；以及瞭解光療法影響褪黑激素之 程度（第三年）。 本研究擬以癌症住院及門診病人為對象，研究工具包括基本資料、匹茲堡睡眠品質 問卷、阿森斯失眠問卷，簡明疲憊量表，貝克憂鬱量表度、SF-36 生活品質量表、腕動 力器等。資料處理分析方式包括：內容分析、描述性統計、t 檢定、皮爾森相關、GEE (generalized estimating equations)等。 本研究之結果將可瞭解光暴露與生物節率與睡眠障礙之間的關係，並可進一步瞭解 光療法作為改善癌症病人睡眠障礙之護理措施之成效，以期，最終能藉由改善癌症病人 之睡眠品質提昇病人之生活品質。

  Lin, C.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Exploitation of Taiwan Native Plants in Promoting Bone Growth and Establishment of the System Biology Platform

  Lee, M.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of Sumoylation on Gsk-3beta-Mediated Autophagy

  Shih, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of the Apoe4 Allele on Cerebral Structural and Functional Connectivity- a Diffusion Tensor Imaging and Resting-State Mri Study

  Chen, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Novel Roles of Arnt in Breast Tumor Progression, Metastasis and Therapy

  Chang, W.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Functional Electrical Stimulation on the Study of Nerve Regeneration in the Rat with Diabetic Neuropathy

  Peng, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Neurotrophic/Neuroprotective Role of Gip in Cellular and Rodent Models of Mild Traumatic Brain Injury.( I )

  Lin, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Preparation and Evaluation of Tea Polyphenol Contained Nanocarriers for Ophthalmic Application

  Tseng, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Improvement of Cryopreservative Effect of Natural Killer Cell by Increasing Membrane Rigidity Using Static Magnetic Field

  Huang, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Macro and Micro Biomechanical Studies of Soft Tissue Remodeling under Tissue Expansion (II)

  Chen, H.

  8/1/12 → 1/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討鎮靜藥物dexmedetomidine保護腦血管免於缺血-再灌流傷害之機轉: 細胞和動物研究

  Wu, G.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• CAAT/enhancer binding protein beta訊息路徑參與thrombin誘導人類肺部上皮細胞IL-8/CXCL8表現之研究

  Chen, B.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Chinese Herbal Compound Extract of Pig Sperm Detection and Activation of the Pharmacokinetic Evaluation and Preparation of R &Amp; D

  Lee, C.

  8/1/12 → 12/31/13

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Integrative Studies on Falls, Osteoporosis, and Fractures in Older People

  Lin, M.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role and Molecular Mechanism of Pparα in Acute Kidney Injury: Focus on the Protective Effect in Renal Tubular Cell

  Hsu, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Novel Development of Continuous Bladder Volume Measurement System

  Chen, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探究腦指蛋白 ZNF179 (Brain Finger Protein) 的分子機制

  Huang, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Roles of Autophagy and Heme Oxygenases(-1, -2) in Brain Injuries: in Vivo and in Vitro Studies

  Wang, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Translational Genomic Approaches in Endometriosis

  Tzeng, C., Kao, S., Huang, Y., Yang, W., Yang, W., Yeh, C., Li, Y. & Shen, S.

  8/1/12 → 10/31/13

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Role of Sp-Family in Lung Tumorigenesis

  Chang, W.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Laser Enhancement of Transdermal Delivery of Nanoparticles

  Lee, W.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Roles of Fibronectin Fragments in the Articular Chondrocytes: from Single Nucleotide Polymorphism to Functional Investigation.

  Lee, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Targeting Hif-1α by Zebularine for the Treatment of Colorectal Cancers

  Yang, P.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Drug Adherence,Adverse Events,And Impacts on Quality of Life in the Use of Biologic Agents among Patients with Immune-Mediated Inflammatory Diseases

  Tang, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討加護病房多種致病微生物揮發性有機成分

  Shih, C.

  7/25/12 → 11/30/12

  Project: A - Government Institution › f - Other (Funded by Government)

• The studies and analysis of the addiction,abuse and social risk of emerging abused drugs

  Sheu, S.

  7/10/12 → 12/31/12

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 護理碩士進階實務人才培育共識論壇

  Lin, C.

  7/6/12 → 7/27/12

  Project: A - Government Institution › d - Ministry of Education

• 以混合羅吉特模型分析機車路口使用兩段式左轉之行為

  Pai, C.

  7/5/12 → 9/3/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 101年度建置健保法學知識數位平台

  Yang, C.

  6/29/12 → 12/28/12

  Project: A - Government Institution › c - Ministry of Health and Welfare

• Research Symposium for Chinese Medicine Research Projects

  Liang, W., Huang, W. & Lin, M.

  6/1/12 → 12/15/12

  Project: A - Government Institution › c - Ministry of Health and Welfare

• Study of solid cultivated fruit bodies of Antrodia camphorata combined with or without aspirin on neuroprotection and lowering the neurobehavioral deficits in rat ischemic stroke: evaluating the risks of inducing hemorrhagic side effects.

  Sheu, J.

  6/1/12 → 12/31/12

  Project: A - Government Institution › e - Council of Agriculture

• Feasibility of Capitation for the Accountable Family Physician System: An Exploratory Study

  Sheu, M., Hsu, Y. & Wen, H.

  5/2/12 → 3/31/13

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 探討女性糖尿病患之泌尿道症狀、睡眠品質與糖尿病控制的相關

  Liao, Y.

  5/1/12 → 4/30/13

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 以超靈敏奈米線感測器偵測口腔癌症指標

  Wu, C.

  5/1/12 → 5/31/13

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 以前瞻性乳房專用MRI追蹤方式，觀察婦女服用女性動情激素荷爾蒙或非藥物性食品/補充品((包含植物性（主要是動情激素）)，比較停藥前後和使用藥物前後對乳房MRI影像的影響

  Leung, T.

  5/1/12 → 12/31/13

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 探討以植物化學成分抑制β-catenin/PIN1訊息傳道路徑於肝癌幹細胞的發生

  Wu, T. A.

  5/1/12 → 4/30/13

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• Development of Novel Therapeutic Agents for Breast Cancer through Targeting Nicotinic Acetylcholine Receptors.

  Wu, C., Ho, Y. & Lee, C.

  5/1/12 → 4/30/13

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 巴金森氏病之嗅覺腦波頻譜分析及嗅覺誘發電位研究

  Chiu, H.

  5/1/12 → 4/30/13

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 老人跌倒傷害型態及出院後住所對存活、住院、再跌倒、及日常活動能力變化之影響

  Lin, M.

  5/1/12 → 4/30/13

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 第四型類鐸接受器在大腸直腸癌化學治療效果上的角色及其作用機制探討

  Huang, M.

  5/1/12 → 4/30/13

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 注射含氫氧基磷灰石之填補物於軟組織缺損填補之安全性評估

  Yang, J.

  5/1/12 → 4/30/14

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 人類凝血脢調節素在乳癌上診斷及治療上的意義

  Huang, M.

  5/1/12 → 4/30/13

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• c-Src/NADPH oxidase/ROS訊息路徑參與表皮生長因子誘導人類大腸癌細胞heme oxygenase-1表現之研究

  Chen, B.

  5/1/12 → 4/30/13

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 探討Zc3h12a及Zc3hav1L在結腸直腸癌生長上所扮演的角色

  Liang, Y.

  5/1/12 → 4/30/13

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 子宮病變與環境荷爾蒙之關係研究

  Lee, C.

  5/1/12 → 4/30/13

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 計劃時程生產與自然時程生產之醫療費用分析

  Sheu, M.

  5/1/12 → 7/31/13

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 整合醫院資訊系統、數據收集和資訊代表性技術的挑戰

  Li, Y.

  5/1/12 → 4/30/13

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 淋巴管內皮細胞粒腺體導致細胞死亡的關鍵角色探討

  Sheu, J.

  5/1/12 → 4/30/13

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 以PRP高濃度血小板血漿促進前十字韌帶重建手術加強痊癒之研究

  Lee, C.

  5/1/12 → 4/30/13

  Project: C - Project of Alliance › p - Taipei Medical University Hospital