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Endothelin-1 Mediates Fibrocyte Differentiation in Chronic Obstructive Asthma

Lin, C.

8/1/1210/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Phosphoproteomic Study on Mechanisms of Silymarin Modulating Fungicide Induced Sperm Dysfunction

Wu, T.

8/1/1210/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Molecular Therpary and Mechanism Study in Spinal Cord Injury

Hung, K.

8/1/1210/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

探討北縣市國小及國中學生鐵營養值標與肥胖及新陳代謝症候群的關聯

Chang, J.

5/1/1210/31/13

Project: C - Project of Allianceo - Taipei Medical University Hospital

Studies of Cxcl12 in Hypoxia-Induced Pulmonary Fibrosis

Chen, B.

8/1/1210/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of miR-1 in RAS Mutation Prostate Cancer Metastasis

Liu, Y.

1/1/1310/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Role and Use of Blood Protein Fractions in Translational Therapy

Burnouf, T. P. R.

1/1/1310/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

睡眠困擾是癌症病人最常主訴的問題之一。患有睡眠困擾之癌症病人經常同時伴隨 疲憊、憂鬱等現象發生,形成症狀群集,影響生活品質。雖然目前對於癌症病人睡眠障 礙之量性研究已多有著墨,然而對於癌症病人經歷睡眠障礙之主觀經驗之瞭解,仍相當 有限。瞭解病人經歷睡眠障礙之主觀經驗,將有助於未來睡眠評估工具之修訂。另外, 在評估癌症病人睡眠品質時,若能以簡單工具評估,會更具效率及助益。阿森斯失眠量 表(Athens Insomnia Scale, AIS) 是一個簡單的8 題問卷,廣為使用在一般失眠的病人, 在癌症病人使用上,尚未有豐富的實證資料,若能建立其在癌症病人的信效度,將可作 為一簡單篩檢癌症病人失眠的工具。 睡眠遵行日夜節律規則,日夜節律又需要光作為矯正的線索,光在癌症病人睡眠的 角色,尚未有研究證實,過去研究顯示癌症病人睡眠品質不佳與生物節律有關係。光是 重要日夜節律的線索,光療法透過褪黑激素調節,調整日夜節律週期,可能可以改善睡 眠品質。另外,由於,睡眠障礙、憂鬱、疲憊經常形成一症狀群集,光療法於改善睡眠 障礙之同時,是否亦同時改善憂鬱、疲憊及生活品質。目前,光療法在癌症病人的運用 上,付之闕如,故建立光療法於癌症病人的有效性值得探究。 本研究為三年期研究計畫,目的包括有:1.瞭解癌症個案對於睡眠困擾的主觀經驗 (第一年)。2.建立阿森斯失眠量表中文版的信效度、敏感性、特異性(第一年)。3.瞭 解癌症病人光暴露與生物節率、睡眠障礙的關係(第二年)。4.瞭解光療法對於改善癌 症病人睡眠障礙及相關症狀群集、及生活品質之成效;以及瞭解光療法影響褪黑激素之 程度(第三年)。 本研究擬以癌症住院及門診病人為對象,研究工具包括基本資料、匹茲堡睡眠品質 問卷、阿森斯失眠問卷,簡明疲憊量表,貝克憂鬱量表度、SF-36 生活品質量表、腕動 力器等。資料處理分析方式包括:內容分析、描述性統計、t 檢定、皮爾森相關、GEE (generalized estimating equations)等。 本研究之結果將可瞭解光暴露與生物節率與睡眠障礙之間的關係,並可進一步瞭解 光療法作為改善癌症病人睡眠障礙之護理措施之成效,以期,最終能藉由改善癌症病人 之睡眠品質提昇病人之生活品質。

Lin, C.

8/1/1210/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

行政院衛生署所屬醫院「102年度滿意度調查評估」勞務委託採購案

Kuo, N.

6/18/1310/28/13

Project: A - Government Institutionf - Other (Funded by Government)

Motorcyclist Behavioural Patterns to Pedestrian Green Signal Countdown Device (Pgscd): a Mixed Logit Analysis

Pai, C.

8/1/129/30/13

Project: A - Government Institutionb - Ministry of Science and Technology

Study the bacteria species of pneumonia and early detect the pathogen from expired gas by electronic nose

Shih, C.

5/1/129/30/13

Project: A - Government Institutionb - Ministry of Science and Technology

Roles of Central Orexin Activities in the Pathophysiology of Hypertension in Shr

Hwang, L.

8/1/129/30/13

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of Maternal Depressive Symptomatology on Pregnancy Outcomes and Newborn Development---How Is Paternal Psychopathology Involved?

Chen, Y.

8/1/129/30/13

Project: A - Government Institutionb - Ministry of Science and Technology

Chemokine Factors Concomitantly Induce Prostate Cancer Organ Specific Bone Metastasis

Sung, S.

8/1/129/30/13

Project: A - Government Institutionb - Ministry of Science and Technology

以混合羅吉特模型分析機車路口使用兩段式左轉之行為

Pai, C.

7/5/129/3/13

Project: A - Government Institutionb - Ministry of Science and Technology

Teledermatology Solutions Though Mobile Phone

Li, Y.

9/1/128/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

102年癌症篩檢管理中心工作計畫之個管師考題研擬及閱卷

Chen, L.

6/13/138/31/13

Project: A - Government Institutionc - Ministry of Health and Welfare

慢性肝病在台灣是一個極具挑戰性的臨床議題。肝纖維化的多重病原性是造成病患死亡 率增加的原因,而且肝纖維化往往會發展成肝癌。我們最近利用國民營養調查資料庫 (NAHSIT 2005-2008)分析國人血中鐵營養值標與代謝症候群的相關性.在全人口的分析 中,我們發現校正了血清發炎指標以及飲食的營養指標後, serum ferritin (鐵蛋白質) 高於最大三等分位的族群,得到代謝性症候群的危險對比值超過 1.6 倍. 目前並不清楚 過量的鐵蛋白質為何與代謝症候群的發生率有關。肝臟為重要的儲鐵器官但是臨床研究 也顯示過量的鐵質沉積與肝纖維化及肝癌有極大的相關性。血清中鐵蛋白質為反映體內 儲存鐵的生化質標。但是,發炎因子也會造成血清中鐵蛋白質的異常增加。證據顯示發炎 因子可以調控鐵蛋白質的基因表現量。但是慢性發炎如何造成鐵蛋白質代謝異常(組職 內沉積及釋放)? 血清中的鐵蛋白質又有何生理功能? 隨著國人代謝症候群及脂肪肝發生率的年輕化,這次研究的主題是以老鼠初代星狀肝細 胞來分析鐵蛋白質對內質網壓力機轉與肝纖維化的影響: 相關研究的主要目標為: 1. 釐清鐵蛋白質(serum ferritin)過量是否會造成星狀細胞內質網壓力增加與活化? 2. 何種鐵質(ferric, ferrous, ferritin, Apoferritin)較易增加內質網壓力? 3. 找出何種內質網壓力的轉錄因子 (ATF6,ATF4, XBP1 and CHOP)受到鐵質調控? 4. 分析鐵質誘導的內質網壓力機轉與肝臟纖維化的營響

Chang, J.

9/1/128/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

A Study of the Influence on Medical University Students$ Beliefs in Mathematics by Liberal Arts Courses in Mathematics Culture

Ying, J.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Study of Anti-Αlpha-Enolase I Antibodies on Cancers and Their Potential Applications

Yang, Y.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Huntingtin-Associated Protein Related Biomarkers in Neural Survival

Lin, Y.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

In vitro and in vivo Evaluation for Silk Fibroin-Coated Electrospun Resorbable Poly(Lactic Acid) GTR Barriers

Yang, J.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Surface Adsorption of Nanomaterials in Applications for Gas Sensor and Catalyst

Lin, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Functional Characterization of Niemann-Pick Type C2 Protein in Hepatocellular Carcinoma

Liao, Y.

1/1/137/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of Cd69 in Tnfalpha-Inhibited Erythroid Differentiation

Huang, H.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Advanced Research for a Decision Model of Emergency Patient Intelligent Dispatch

Hsu, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Epigenetic Regulation of Lps-Induced G-Csf Expression in Macrophages

Chang, S.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Reflex Pelvic Floor Muscle Activities in Women with Urinary Incontinence (Ii)

Yang, J.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

A Translational Study to Confirm the Roles of Gata-Dna Binding Proteins in Bone Healing

Chen, R.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Study of Laser Enhancement of Transdermal Delivery of Nanoparticles

Lee, W.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Motorcycle Exhaust and Metabolic Activation

Ueng, T.

8/1/117/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Pulmonary Effects of Chorioamnionitis and Postnatal Hyperoxia in Rat Offspring

Chen, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Combine Anesthesia Information System with Artificial Neural Networks to Develop the Surgical Complication Pre-Warning System

Lin, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Studies of Molecular and Cellular Underlying Mechanisms of Ferrous Citrate-Induced Cerebral Vasospasm and Brain Injury

Lee, W.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Simultaneous Delivery of an Antisense Oligonucleotide and a Chemotherapeutic Agent by a Her2-Targeted Liposomal System

Chiu, S.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Regulation of Pml Degradation by Sentrin-Specific Protease 2

Chang, C.

11/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of Glutamine Supplementation on T Cell Homeostasis and Inflammatory Response in Inflammatory Bowel Disease

Yeh, S.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Novel Roles of Arnt in Breast Tumor Progression, Metastasis and Therapy

Chang, W.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology