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Roles of Autophagy and Heme Oxygenases(-1, -2) in Brain Injuries: in Vivo and in Vitro Studies

Wang, J.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Studies the Function and Mechanism of Dnaja3a/Dnaja3b and Interaction Molecules during the Embryonic Satges

Chow, J.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

The Role and Molecular Mechanism of Pparα in Acute Kidney Injury: Focus on the Protective Effect in Renal Tubular Cell

Hsu, Y.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Simultaneous Delivery of an Antisense Oligonucleotide and a Chemotherapeutic Agent by a Her2-Targeted Liposomal System

Chiu, S.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

包載9α-型尼古丁乙醯膽鹼受體抑制劑之標靶性微脂體劑型設計與開發

Sheu, M.

8/1/12 → 7/31/13

Project: B - Project of TMU › h - Other (Funded by TMU)

Study the Role of the Endoplasmic Reticulum Stress Related Proteins, Glycoprotein 96(Gp96), in Liver Cancer Progression and Metastasis and the Clinically Therapeutic Implication

Huang, M.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Studies on the Carcinogenic Mechanisms of Histamine N-Methyltransferase-Mediated Breast Cancer Formation

Wu, C.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Studies of Cxcl12 in Hypoxia-Induced Pulmonary Fibrosis

Chen, B. & Chung, C.

8/1/12 → 7/31/13

Project: B - Project of TMU › h - Other (Funded by TMU)

Translational Genomic Approaches in Endometriosis

Tzeng, C., Kao, S., Huang, Y., Yang, W., Yang, W., Yeh, C., Li, Y. & Shen, S.

8/1/12 → 10/31/13

Project: B - Project of TMU › h - Other (Funded by TMU)

Chinese Herbal Compound Extract of Pig Sperm Detection and Activation of the Pharmacokinetic Evaluation and Preparation of R &Amp; D

Lee, C.

8/1/12 → 3/31/14

Project: A - Government Institution › b - Ministry of Science and Technology

Chinese Herbal Compound Extract of Pig Sperm Detection and Activation of the Pharmacokinetic Evaluation and Preparation of R &Amp; D

Lee, C.

8/1/12 → 12/31/13

Project: B - Project of TMU › h - Other (Funded by TMU)

Renoprotective Mechanisms of Soy Protein in Rats with Diabetic Nephropathy

Chen, J.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Novel Roles of Arnt in Breast Tumor Progression, Metastasis and Therapy

Chang, W.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

環境正義視野下的流域治理：石門水庫集水區上游泰雅族部落永續發展策略之行動研究－石門水庫集水區整治之 政策分析：一個環境治理的觀點(III)

Lin, Y.

8/1/12 → 10/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Development a Tissue-Like Block by Novel Porous Calcium Phosphate Combined Dental Pulp Stem Cells and Platelets Rich Fibrin for Bone Regeneration in Large Bony Defect

Lee, S.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Role of Er Stress in Evodiamine-Induced Apoptosis and G2/M Arrest of Human Colorectal Carcinoma Cells

Chen, Y.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Functional Role of Transcription Factor Sp1 in Brain Neuronal Injury( I )

Chang, W.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

21世紀的公民與風險：全球變遷中的環境，知識和價值

Chiou, H.

8/1/12 → 12/31/13

Project: A - Government Institution › d - Ministry of Education

Lay Health Knowledge Research:Example of Infants and Children Dietary Supplement

Chen, Y. C.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

The Biological Mechanisms of N-3 Polyunsaturated Fatty Acid Treatment in Interferon-Induced Depression

Huang, S.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Effects of Adlay Hull Extracts on Polycystic Ovary Syndrome (Pcos)

Hsia, S.

8/1/12 → 10/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Community-Based Screening and Prevention Model for Periodontal Disease

Chen, L.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Design and Evaluation of a Novel Drug-Containing Ceramic Hydrogel for the Healing of Alveolar Bone Defect

Lee, S.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Translational Genomic Approaches in Endometriosis

Tzeng, C.

8/1/12 → 10/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Oxidative Stress and Bisphenol a Impact on the Women with Polycystic Ovary Syndrome

Hsu, M.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Motorcyclist Behavioural Patterns to Pedestrian Green Signal Countdown Device (Pgscd): a Mixed Logit Analysis

Pai, C.

8/1/12 → 9/30/13

Project: A - Government Institution › b - Ministry of Science and Technology

Chemokine Factors Concomitantly Induce Prostate Cancer Organ Specific Bone Metastasis

Sung, S.

8/1/12 → 9/30/13

Project: A - Government Institution › b - Ministry of Science and Technology

Bullying Experience, Attitude and Suicide Attempts among Adolescents

Chen, P.

8/1/12 → 7/31/14

Project: A - Government Institution › b - Ministry of Science and Technology

探究腦指蛋白 ZNF179 (Brain Finger Protein) 的分子機制

Huang, C.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Study the Klf10 Alters Metabolic Pathways in Genetic-Deficient Mice and Human Pancreatic Ductal Carcinomas

Chang, H.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Advanced Research for a Decision Model of Emergency Patient Intelligent Dispatch

Hsu, C.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

依療法律與醫學倫理

Ho, J.

8/1/12 → 1/31/13

Project: A - Government Institution › d - Ministry of Education

The Neurotrophic/Neuroprotective Role of Gip in Cellular and Rodent Models of Mild Traumatic Brain Injury.( I )

Lin, J.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Application of Functional Electrical Stimulation on the Study of Nerve Regeneration in the Rat with Diabetic Neuropathy

Peng, C.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Enhancement of Immuno-Modulatory Capacity by Shear Stress in Mesenchymal Stem Cells

Ho, J.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Translational Studies of Mycobacterium Tuberculosis-Induced Lung and Pleural Fibrosis

Lin, C.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

The Novel Development of Continuous Bladder Volume Measurement System

Chen, S.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

The Effects of Music Therapy on Psychological Distress and Functional Recovery in Patients with Stroke

Chang, H.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Drug Adherence,Adverse Events,And Impacts on Quality of Life in the Use of Biologic Agents among Patients with Immune-Mediated Inflammatory Diseases

Tang, C.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Investigation on Developing Novel Biomarkers and Treatments in the Patients with Fibromyalgia

Kang, J.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Oral Health and Interventions for Elderly in Long-Term Care Facilities

Chang, C.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Molecular Mechanisms of Propofol-Involved Protection against Ischemia Brain Injuries

Chen, T.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

睡眠困擾是癌症病人最常主訴的問題之一。患有睡眠困擾之癌症病人經常同時伴隨 疲憊、憂鬱等現象發生，形成症狀群集，影響生活品質。雖然目前對於癌症病人睡眠障 礙之量性研究已多有著墨，然而對於癌症病人經歷睡眠障礙之主觀經驗之瞭解，仍相當 有限。瞭解病人經歷睡眠障礙之主觀經驗，將有助於未來睡眠評估工具之修訂。另外， 在評估癌症病人睡眠品質時，若能以簡單工具評估，會更具效率及助益。阿森斯失眠量 表(Athens Insomnia Scale, AIS) 是一個簡單的8 題問卷，廣為使用在一般失眠的病人， 在癌症病人使用上，尚未有豐富的實證資料，若能建立其在癌症病人的信效度，將可作 為一簡單篩檢癌症病人失眠的工具。 睡眠遵行日夜節律規則，日夜節律又需要光作為矯正的線索，光在癌症病人睡眠的 角色，尚未有研究證實，過去研究顯示癌症病人睡眠品質不佳與生物節律有關係。光是 重要日夜節律的線索，光療法透過褪黑激素調節，調整日夜節律週期，可能可以改善睡 眠品質。另外，由於，睡眠障礙、憂鬱、疲憊經常形成一症狀群集，光療法於改善睡眠 障礙之同時，是否亦同時改善憂鬱、疲憊及生活品質。目前，光療法在癌症病人的運用 上，付之闕如，故建立光療法於癌症病人的有效性值得探究。 本研究為三年期研究計畫，目的包括有：1.瞭解癌症個案對於睡眠困擾的主觀經驗 （第一年）。2.建立阿森斯失眠量表中文版的信效度、敏感性、特異性（第一年）。3.瞭 解癌症病人光暴露與生物節率、睡眠障礙的關係（第二年）。4.瞭解光療法對於改善癌 症病人睡眠障礙及相關症狀群集、及生活品質之成效；以及瞭解光療法影響褪黑激素之 程度（第三年）。 本研究擬以癌症住院及門診病人為對象，研究工具包括基本資料、匹茲堡睡眠品質 問卷、阿森斯失眠問卷，簡明疲憊量表，貝克憂鬱量表度、SF-36 生活品質量表、腕動 力器等。資料處理分析方式包括：內容分析、描述性統計、t 檢定、皮爾森相關、GEE (generalized estimating equations)等。 本研究之結果將可瞭解光暴露與生物節率與睡眠障礙之間的關係，並可進一步瞭解 光療法作為改善癌症病人睡眠障礙之護理措施之成效，以期，最終能藉由改善癌症病人 之睡眠品質提昇病人之生活品質。

Lin, C.

8/1/12 → 10/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Dissected the Role of Alpha-7 Nicotinic Receptor in the Prognosis and Clinical Therapy on Gastric Cancers

Chang, Y.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Roles of Toll-Like Receptor-4 and Hif-1 in Propofol-Involved Protection against Traumatic Brain Injury-Induced Dysfunction of the Blood-Brain Barrier

Chang, H.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

A Clinical Correlation Study of Dna Methyltransferases Alterations in Breast Cancer and Evaluation of Dna Methyltransferases as a Therapeutic Target in Cell and Animal Models

Lin, R.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Molecular and Cellular Mechanism of Adipocyte Modulatory Effects on Pulmonary Vein and Atrium

Chen, Y.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Targeting Hif-1α by Zebularine for the Treatment of Colorectal Cancers

Yang, P.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Improvement of Cryopreservative Effect of Natural Killer Cell by Increasing Membrane Rigidity Using Static Magnetic Field

Huang, H.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology

Effects of Childhood Sleep Deprivation on the Development of Emotional Control and Cognitive Function of Prefrontal Cortex

Chang, H.

8/1/12 → 7/31/13

Project: A - Government Institution › b - Ministry of Science and Technology