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The Emerging Role That Splicing Factor Plays in the Adipose Development

Lin, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Functional Role of Transcription Factor Sp1 in Brain Neuronal Injury (II)

Chang, W.

8/1/137/31/14

Project: B - Project of TMUh - Other (Funded by TMU)

An association study of arsenic exposure, inflammation, oxidative stress and the risk of developing cardiovascular diseases

Hsieh, F.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

山藥儲藏性蛋白質功能性月生月太之延緩衰老功能評估與機制探討(1/3)

Hou, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of a program of mind-body interventions on psychological resilience, vagal tone, emotional states, and outcomes of heart failure

Tsai, P.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Studies on the anti-islet hypertrophy and anti-osteoporosis constituents from Formosan Fern

Hsu, F.

8/1/1312/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Association Study of Genetic Polymorphisms of Toll-Like Receptors on Ischemic Stroke (I)

Chiou, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The role of DDX3 in human papillomavirus-infected lung tumorigenesis

Lee, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

SHE(Smart Health Elderly)的社區照護

Shiao, Y.

8/1/137/31/14

Project: A - Government Institutiond - Ministry of Education

Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors

Lee, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Research of preparation and antibacterial mechanism on metal containing yttria-stabilized zirconia ceramics.

Ou, K.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

A Novel Porcine Bone Xenograft Development

Chang, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Trends in Surgical Litigation and Media Coverage of Medical Malpractice: Implications for Medical Education

Lyu, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Lipid Raft Associated Signaling in Regulation of Osteoclast Activation in Inflammatory Arthritis

Tsai, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Cellular and Molecular Mechanisms of Nicotine and Nitrosamines Promote Tumorigenic Behaviors in Renal Cell Carcinoma (Ii)

Cheng, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

探討小泛素蛋白酶Sentrin-specific protease 2 參與轉型生長因子-beta訊息傳遞的作用機制(1/2)

Chang, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The association of early-onset ischemic stroke and the aging of vascular system using the telomere length related genes

Hsieh, F.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Study of Context Aware Knowledge Supporting Systems---A Case Study of Premature Neonates Care

Liu, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

A translational study to confirm the roles of GATA-DNA BINDING PROTEINS in bone healing

Chen, R.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Development of Strontium-Impregnated Bioabsorbable Bone Screw for Fracture Fixation in Osteoporotic Bone

Yang, K.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Effects of LED Light on Porphyromonas gingivalis in Periodontitis for Anti-Inflammation and Alveolar Bone Regeneration

Deng, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Development of a Computerized Adaptive Testing of the Health Literacy in Stroke Rehabilitation.

Hou, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Discovery of Rare and Common Variants in Genetic Association Studies

Cheng, K.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

大腸直腸癌已躍居世界上癌症死亡率第二名,屬於固體型腫瘤,缺氧常見於此類 腫瘤,並誘發HIF-1α 表現而導致抗藥性及預後較差,因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑,可殺死癌 細胞而不影響正常細胞,對小鼠也不具毒性。我們初步結果顯示,Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現,代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性,對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下,經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制;也有研究報導指出,藥物會誘導癌細胞產生autophagy,造成細胞過度吞噬其內容 物而死亡,因此,autophagy在癌細胞為保護或是引發毒殺作用,目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活,但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示,除抑制HIF-1α 表現外,Zeb 也可活化AMPK、UPR/ER stress、以及autophagy, 因此我們推測Zeb 可在缺氧狀態下,促進autophagic cell death。3 年內我們將執行4 項 目標: (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。(第一年) (2) 研究Zeb 抑制HIF-1α表現之分子機轉。(第一年到第二年) (3) 研究Zeb 誘發autophagy之分子機轉。(第二年到第三年) (4) 探討Zeb 對缺氧導致抗藥性之作用。(第三年)

Yang, P.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Distribution of the Number of False Discoveries in Genome-Wide Linkage Scan

Wang, W.

8/1/137/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

Hospital Patient Safety Culture-Comparison of Major Measurement Tools, Promotion Methods and Their Evaluation

Kuo, N.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Effect of Muscle Strength Training on Body Composition and Sarcopenic Obesity among the Female Overweight Elderly

Liou, T.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Effects of Metabolic Abnormalities on Cognitive Function in Schizophrenic Patients

Lu, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

樂活隨身科技-獨居高齡者之周全健康照護計畫

Chang, C., Tseng, I. J., Chang, C., Liu, F. & Hou, W.

8/1/137/31/14

Project: A - Government Institutiond - Ministry of Education

Real-Time Single-Cell Probing of the Action Mechanism of Amphotericin B Ion Channels---From Extracellular to Intracellular

Yang, T.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

A Methodology Study of Integrating Systems Thinking and Bayesian Network in Health Policy

Chuang, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Applications of Α-Galactosylceramide-Incorporated Liposome as a Targeting Antigen Carrier for Cancer Vaccine Therapy

Liu, D.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

A Multidisciplinary Study of the Pathophysiology of Blast-Induced Mild Traumatic Brain Injury

Chiang, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

利用基因工程誘導性潛能幹細胞治療巴金森氏症之研究

Chiang, Y.

8/1/137/31/14

Project: B - Project of TMUh - Other (Funded by TMU)

Therapeutic Strategies for Traumatic Brain Injury with Novelly Desinged Drugs (II)

Wang, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Therapeutic Strategies for Traumatic Brain Injury with Novelly Desinged Drugs (II)

Wang, J.

8/1/137/31/15

Project: B - Project of TMUh - Other (Funded by TMU)

Application of Functional Electrical Stimulation on the Study of Nerve Regeneration in the Rat with Diabetic Neuropathy

Peng, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Roles of Central OX2R Activities in the Pathophysiology of Hypertension in SHR

Hwang, L.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

TMU101-AE1-B63

Chen, C.

8/1/137/31/14

Project: C - Project of Allianceo - Taipei Medical University Hospital

Pulmonary effects of chorioamnionitis and postnatal hyperoxia in rat offspring

Chen, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology