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  治療膠質母細胞瘤之新穎小分子多標靶抗癌藥物之設計合成與開發

  Huang, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Research and development of on-line incremental Learning schemes for Big Data Analytics in non-stationary environments

  Chiang, I.

  8/1/16 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 繪本教學介入對學齡期自閉症兒童人際互動之成效探討

  Kuo, S.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新穎性選擇性HDAC抑制劑之抗癌藥物開發與藥理機轉探討(3/3)

  Pan, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mechanisms by Which Enterovirus-Host Interactions Form Viral Replication Organelles and Regulate Viral Replication

  Lin, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Epigenetic Targeting for Potential Tumor Suppressor Genes, Poldip2 and Sox1, with Investigations of Prognostic and Therapeutic Implications in Non-Small Cell Lung Cancer

  Tzao, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Associated Factors of Smoking around School-Aged Children and the Intervention Development Using the Theory of Reasoned Action

  Chen, P. & Shiau, F.

  8/1/10 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular Epidemiology of Urothelial Carcinoma Prognosis Based on Microrna Expression Profiles

  Wang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Neurofeedback and Rsa Biofeedback on Quality of Sleep in Patients in the Chronic Phase of Traumatic Brain Injury

  Tsai, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Fragment-Based Discovery of First-In-Class Small-Molecule Kinase Inhibitors for Targeted Cancer Therapies( I )( I )

  Huang, H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The role of DDX3 in human papillomavirus-infected lung tumorigenesis

  Lee, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploring the effects of an exercise program on female diabetic patients$ health

  Liao, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Incidence of and Factors Related to Urogenital Symptoms around the Menopause, Correlation between Urogenital Symptoms and Quality of Life (Qol), and the Effects of an Exercise Health Promotion Program on Women's Urogenital Health, QOL, and Knowledge

  Liao, Y., Chang, L. & Jeng, C.

  8/1/10 → 12/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Developing an Assessment and Rehabilitation System for Improving Bilateral Ankle Coordination Control and Functional Performances of Lower Limbs Following Chronic Stroke-II(1/2)

  Lin, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 攝護腺癌之精準代謝治療(3/3)

  Kung, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 纖維肌痛症：不同症狀表現型對生活品質之影響及科技輔助適性健康教練方案之成效(3/3)

  Tsai, P.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 行人低頭族風險行為探討: 以虛擬擴增實境遊戲、賽車遊戲為例

  Pai, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Exercise Intentions and Behaviors of Students in Metropolitan Areas---A Longitudinal Study

  Lee, P.

  8/1/14 → 1/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Motorcyclist Behavioural Patterns to Pedestrian Green Signal Countdown Device (Pgscd): a Mixed Logit Analysis

  Pai, C.

  8/1/12 → 9/30/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Electrophysiological and Molecular Insights into the Cardiac Regulations of ZFHX3 Gene---Implication in the Pathophysiology of Atrial Fibrillation

  Chen, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Bicycle Taillights and Reflective/Led Clothing on Motorists’ Overtaking/Tailgating Behaviours: an On-Field Observation Study

  Pai, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Human Leukocyte Antigen Polymorphisms Associated with the Efficacy of Hepatitis B Virus Vaccination

  Su, F.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展用於促進中風患者雙側踝關節協調控制與下肢功能表現之評估與復健系統-II(2/2)

  Lin, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Galectins-Immune Signaling Reprograming in Atrial Remodeling and Arrhythmogenesis: a Novel Therapeutic Strategy for Atrial Fibrillation(2/3)

  Chen, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 長鏈非編碼缺氧誘發核醣核酸 LncHIFCAR之內含性微小核糖核酸miR- 31在胰臟癌進程的功能性角色

  Shih, J.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Using Artificial Intelligence and Data Science to Build Cloud-Base Cardiovascular Diseases Home Care Service Platform under Personal Cardio-Health Care Premium Model

  Chen, C.

  11/1/19 → 10/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Electrophysiological and Molecular Insights into the Cardiac Regulations of ZFHX3 Gene---Implication in the Pathophysiology of Atrial Fibrillation

  Chen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Detecting Genetic Variants Based on a Random-Effects Model

  Cheng, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Roles of microRNA96 in TGF-beta-Mediated Tumor Progression

  Tsai, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Building The Big Data Database of Technological Innovation, Research and Development (Ⅱ)

  Shia, B.

  3/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Longitudinal Study of the Individualized Walking Exercise Program on Memory, Subjective Cognitive Complaint, and Brain-Derived Neurotrophic Factor (Bdnf) among Postmenopausal Hypertensive Women

  Chou, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Mechanistic Action of DDX3 in Colorectal Tumor Progression

  Lee, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Characterization of Glioblastoma Using Advanced Multimodal Small Animal Mr Imaging Techniques

  Liu, H.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Identification of Osteoporosis Susceptibility Gene in Calcium Signaling Pathway -Second and Third Years

  Hung, K.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Gene Signatures and Potential Therapeutic Targets of Amino Acid Metabolism in Estrogen Receptor-Positive Breast Cancer(1/2)

  Wang, C.

  1/1/20 → 12/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Characterization of Lncrna-Kdm4 Axis in Hypoxic Oral Cancer(1/3)

  Kung, H.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Host Factors Affecting the Pathogenesis of Enterovirus 71 in Neuron and Non-Returnable Cells

  Lin, J.

  12/1/14 → 11/30/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Series of Study in Lifestyle Analysis and Exploration of the Effect of Cognitive-Behavioral Intervention among High Risk Subjects with Family History of Colorectal Cancer

  Jeng, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Discovery of Rare and Common Variants in Genetic Association Studies

  Cheng, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Explore the Spread of Evidence-Based Nursing---The Indicator of Lifelong Learning Ability and Develop Nursing Clinical Guideline

  Lin, C.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• A cross-culture moral developmental study (USA, France and Taiwan): Incorporating neuroimaging, behavioral investigation and artificial intelligence to develop models for behavior prediction.(2/5)

  Chen, C.

  2/1/20 → 1/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Promoting Healthy Eating---A Family-Centered Obesity Prevention Randomized Control Trial for Preschool Children

  Chang, P.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 強化藍光之白光光照法改善纖維肌痛症患者睡眠、憂鬱、神經運動警覺度及症狀嚴重度之成效(1/3)

  Tsai, P.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 102 年東南亞區域共同研究暨培訓型國際合作計畫—社區精神復健合作研究平台與專業人員培訓工作坊

  Tsai, D.

  6/1/13 → 12/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Long Acting GnRH Agonist Treatment on Mitochondrial Function in

  Tzeng, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Electrophysiological Activity and Functional Correlates in Female Pelvic Floor Muscles(2)

  Yang, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• From Hospital to Community: Longitudinal Changes of Participation in Younger Stroke Survivors

  Chang, F.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 青少年期慢性睡眠剝奪對認知、情緒與壓力調適功能之影響:動物模式與人類世代之整合研究-青少年期慢性睡眠剝奪對認知、情緒與壓力調適功能之影響:健康青少年族群之觀察追蹤與介入研究(2/3)

  Lee, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 骨質疏鬆及肌少症影像人工智能分析計畫

  Kuo, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology