Find Research Projects

Search results

• b - Ministry of Science and Technology

  價創計畫：微創手術AI輔助影像辨識系統-以婦科子宮動脈阻斷術為模型

  Chen, C.

  7/1/20 → 12/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 小分子抗前列腺癌之藥物研發

  Liou, J.

  6/1/16 → 4/30/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• miR-103/107在大腸癌幹性中所扮演的角色探討

  Chen, H.

  4/1/16 → 9/30/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• FGF9在急性腎損傷與發展至慢性腎臟病進程之角色探討(1/3)

  Cheng, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 研究CHRM4作為前列腺癌新穎生物標靶之應用與治療策略

  Liu, Y.

  6/1/21 → 5/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 癌症代謝重整對肥胖相關乳癌之分子調控與轉譯價值

  Lin, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Chitosan Nanopolyplex Mediated Delivery of Anti-Fibrotic Mirna for the Treatment of Oral Submucous Fibrosis (1/3)

  Yang, K.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Smart Multifunctional Nanocarriers for Oral Delivery of Thrombolytic Enzymes (1/3)

  Mi, F.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討COVID-19對護理人員的心理健康影響

  Chiu, C.

  7/1/22 → 2/28/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• 102 年東南亞區域共同研究暨培訓型國際合作計畫—亞洲 15 國衛生識能國際合作比較研究與研習教育計畫

  Chang, W.

  6/1/13 → 12/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Kidney Injury and Heat Shock Protein Modulate the Atrial Electrophysiological Characterisitcs

  Hsieh, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Epigenetic Regulation of Lps-Induced G-Csf Expression in Macrophages

  Chang, S.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Lay Health Knowledge Research:Example of Infants and Children Dietary Supplement

  Chen, Y. C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• EBP1蛋白質對於細胞及病毒IRES的影響及其作用機轉

  Lin, J.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Galectins-Immune Signaling Reprograming in Atrial Remodeling and Arrhythmogenesis: a Novel Therapeutic Strategy for Atrial Fibrillation

  Chen, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of the Intestinal Health-Improvement Factors on Leaky Gut Syndrome, Gut Microbiota Diversity and Sarcopenia in Rats with Alcoholic Liver Diseases Based on Gut-Liver-Muscle Axis

  Yang, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular Epidemiology, Related Risk Factors and Phylogenetic Analysis of Epilepsy-Causing Neurotoxocariasis or Neurocysticercosis in the Kingdom of Eswatini, Africa

  Fan, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建置與評估可擴充式機器學習演算法之重症醫療資訊平台

  Lo, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Single-Stage Cartilage Autograft Implantation System Using Platelet-Rich Fibrin Essence Scaffolds with Particulate Cartilaginous Grafts

  Wong, C.

  7/1/19 → 7/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討黃腐醇合併降血糖藥是否可調控粒線體失常並經由活化未摺疊蛋白反應所激發之AMPK-NRf2-ARE-Glo1路徑來逆轉雙羰基壓力導致之糖尿病腎脂毒性

  Chen, K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 助孕酮受器在葉酸抑制腫瘤細胞生長及轉移所扮演的角色(3/3)

  Lee, W.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 高光譜影像於蛋品之食品安全與品質檢測之研究：發展偵測蛋殼表面裂痕、蛋殼品質、微生物污染、生物胺含量、動物用藥及農藥殘留之多重標的檢測技術

  Chuang, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Smokefreebrain: Multidisciplinary Tools for Improving the Efficacy of Public Prevention Measures against Smoking

  Shabbir, S. A.

  5/1/18 → 4/30/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討肌內效貼紮對於排球運動員跳躍動作之膝關節表現與下肢肌肉影響

  Lin, C.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 具機械強度、可降解及骨誘導能力之鎂基非晶質合金應用於高位脛骨截骨矯正術之骨填充楔開發(2/3)

  Chen, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Therapeutic Potential of Regulation of Prostaglandin E2 Receptor and Autophagy by Endothelin-Converting Enzyme Inhibition in Chronic Kidney Disease( III )

  Chiu, H.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Research on Development of Clound Computing Platform for Decision Support Systems Healthcare by Healthcare Big Data and Analytics

  Chiang, I.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用輸卵管上皮類器官培養技術開發卵巢癌早期偵測之表基因生物標記(3/3)

  Lai, H.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Decoding and Promoting Resilient Brains: from Multivariate Profiling to Intervention

  謝, 淑. & Yang, C.

  1/1/21 → 12/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抗阻力運動介入及肌肉激素分泌對接受放射化學治療子宮頸癌個案改善肌少症與生活品質成效之探討(2/3)

  Tsai, H.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Identification of Roles of microRNAs in Drug Resistance Development of Chronic Myeloid Leukemia

  Shih, C. & Liu, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Explore of Toll-Like Receptors Associated miRNA Expression in Ischemic Stroke Patients (II)

  Wu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 應用多體學策略探討運動對長期及急性睡眠剝奪之運動表現、代謝及神經心理功能影響(3/3)

  Tung, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Aspm-Par-Pcp Signaling in Invasive-Cancer-Stem-Cell-Mediated Metastasis and Its Therapeutic Targeting(1/3)

  Tsai, K. K.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Innovative Applications and Development of Solar Energy-Based Plasmon-Activated Water and Distilled Water Derived from Plasmon-Activated Water(1/3)

  Liu, Y.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the Role of Adam17/Ace2 in Doublecortin Like Kinase 1 (Dclk1) Overexpression Responsible for Airway Fibrosis( I )

  Chen, B.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Prevalence and Effect of Potentially Inappropriate Medication of Elderly in Long Term Care Facility

  Hung, Y.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Service for Sharing Precious Instruments of Taipei Medical University

  Lin, C.

  1/1/13 → 1/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Saliva Alkaloids of Areca Nut or Tobacco, Inflammatory and Antioxidants Status and Oral Hygiene in Periodontitis Patients

  Huang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Blood Sugar Regulation and Molecular Mechanism by White Potato Extract

  Li, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討HIV-1反轉錄酉每與新穎先導藥物之複合體結構以利優化作為抗HIV候選藥物

  Liu, C.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Ccr5-Targeted Liposome Encapsulated Immunosuppressive Drug-Tacrolimus for Autoimmune Disease Treatment

  Liu, D.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建置公衛研究專用之衛星遙測影像環境資料自動化平台

  Chuang, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Design and synthesis of novel dual EZH2 and HSP90 inhibitor

  Liou, J.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mechanistic Investigation of Anticancer Activity of the Site-1 Protease Inhibitor against Hepatocellular Carcinoma (1/3)

  Yang, P.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluation Studies of Haptoglobin and Its Subunits Applied to the Prevention and Prediction of Restenosis

  Wu, C.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• 台灣中醫醫療利用情形、長期趨勢及其影響因素：一項多樣本的大型研究

  Liao, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建構定量系統生理基礎藥動模型以評估腸道菌叢對口服藥物代謝影響及協助奈米膠體處方之開發(1/3)

  Hsieh, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展三功能抗體(EGFR/CD3/mPEG)修飾之聚乙二醇-免疫增敏奈米藥物以主動標靶毒殺大腸癌並同時強化體內T細胞於腫瘤微環境抗癌功效之創新協同療法-開發三功能抗體(EGFR/CD3/mPEG)以協同加成聚乙二醇-免疫增敏奈米藥物及T細胞於大腸癌腫瘤微環境之抗癌功效(2/3)

  Lin, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology