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• b - Ministry of Science and Technology

  The Logic of Care in Miscarriage and ‘An-Tai’ in Taiwan: Adaptive Practice and Accountability from Medical Professionals, Women and Their Partners (1/2)

  Shih, L.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Inhibition of IkB Degradation Reduces Collagen Production via Downregulation of Androgen Receptor Expression in Dihydropyridine-Induced Gingival Overgrowth Cells

  Lu, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Immature Testicular Tissue Engineering for Male Fertility Preservation---A Transgenic Mouse Model

  Chen, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Pre-clinical Investigation of the Anticancer Effects of Polysaccharides Extracted from Ulva Prolifera on Colon Cancer

  Deng, W.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development and Biomechanical Tests of Poly-L-Lactide Bone Screws with CT Imaging Enhancment and 3D Printing Bifunction

  Huang, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Depression Trajectories in Women – a Developmental-Ecological Approach (Gm03)

  Kuo, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular mechanisms of propofol-involved protection against ischemia brain injuries

  Chen, T.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular Mechanisms of Alpha 9-Nicotinic Acetylcholine Receptor (Alpha 9-nAChRs)-Mediated Trastuzumab (Herceptin R) Drug Resistance in Breast Cancer Cells

  Ho, Y.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Biomechanical Comparison of Warm-Up Strategies for Preventing Achilles Tendon Injury

  Chen, H.

  8/1/16 → 8/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Tmu Spark Taiwan-Anchor University Program

  Yen, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 研發選擇性非異羥肟酸組蛋白去乙醯酶 4抑制劑

  Hsu, K.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Modifying the Impact of Maternal Psychopathology on Adverse Infant Health Outcomes---Effects of Paternal Involvement and a Trial on Positive Activity Intervention

  Chen, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Molecular Basis of Senp2 in Regulating Smad4 Sumoylation and Its Functions in Triple Negative Breast Cancer(2/3)

  Chang, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Roles of Hdac6-Mediated Sp1 Deacetylation in the Evolution of Acquired Temozolomide Resistance in Glioblastoma

  Chuang, J.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Chitosan nanoparticle as a macrophage-targeting drug delivery carrier

  Mi, F.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Differential Expression of microRNAs in Osteoblasts and Their Roles in Regulation of Cell Survival and Metabolism

  Chen, R.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluate the Roles and Regulatory Mechanisms of Dicer-Mediated Adsl Expression in Chemosensitization of Dacarbazine and Potentially Combined Treatment with Minnelide in Melanoma

  Lee, W.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Developing New Diagnostic and Therapeutic Strategies for Lung Cancer with ROS1, RET and NTRK1 Mutations in Patients without EGFR, KRAS and ALK Mutations

  Liu, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Reconstruction of Vertebral Body with Delayed Posttraumatic Vertebral Collapse---Biomechanical Evaluation and Redesign

  Chen, H.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of Rice Bran Oil and Frying Rice Bran Oil Combined with Exercise Training on Physical Performance, Gut Microbiota, Fatty Liver Disease and Insulin Resistance in Postmenopausal Condition(2/3)

  Chiu, W.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Optimal Cut-Off Values for Obesity: Investigating Dxa-Based Abdominal Fat Distribution to Predict Cardiovascular Risk Factors in Taiwan

  Tay, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 藉由中孔洞二氧化矽奈米粒子的一種替代原位疫苗接種方法用於癌症免疫治療

  Chen, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 策略訓練對於提升獲得性腦傷患者執行功能的成效(2/3)

  Chang, F.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 優化Co-Cr合金列印於牙科多單位橋體修復物製作之應用

  Fan, F.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 間質幹細胞在低氧微環境促進神經內分泌型前列腺癌的作用與新穎治療策略(1/3)

  Hsieh, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新穎香豆素結構天然植物萃取物於抗血管新生、抗淋巴管新生以及抗發炎之藥理活性評估與機轉探討(1/3)

  Hsu, M.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大學臨床實習生的睡眠時型與睡眠品質：睡眠應激反應與心理韌性的調節作用

  Tsai, P.

  7/1/22 → 2/28/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Manipulating Neural Oscillations in Frequency and Phase Shifting Using Transcranial Alternating Current Stimulation: An Investigation into the Oscillatory Neural Mechanisms of Visual Working Memory(2/3)

  Tseng, P.

  12/1/16 → 11/30/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Trajectory and Biomarkers for Post-Stroke Cognitive Impairment( II )

  Hu, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Emerging and Reemerging Zoonotic Parasitosis Caused by Fish-Borne Parasites: Health Risks Associated with Consumption of Fish

  Fan, C.

  1/1/18 → 12/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 繪本教學介入對學齡期自閉症兒童人際互動之成效探討

  Kuo, S.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 生醫科學雜誌規劃案(1/2)

  Chang, W.

  1/1/18 → 12/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 高性能半透明鈣鈦礦太陽能電池之整合性研究

  Chang, C.

  8/1/17 → 9/21/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the Potential Antitumor Mechanisms of Hyaluronan Synthase Involved in Early Onset Breast Tumor Tissues

  Tu, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 合成劇噻吩石墨烯智慧型基材以建立仿神經元微環境來探討癌症引發之周邊神經侵犯研究

  Huang, W.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 具遠外線與微波脈波測量的穿載式醫療模組- 封裝與驗證(重點主題:A3)

  Chen, C.

  5/1/20 → 4/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mechanistic Studies of Renal Cell Carcinoma: from Rhoa-Mediated Expression of Cd44-Targeting Micrornas to the Development of Biomarkers and Therapies

  Juan, S.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 研究免疫過度激活和腫瘤發生之重要機轉(2/2)

  Chang, S.

  2/1/17 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Aspects of the self: Using multi-modal imaging to intrinsic activity, the body, and self-ascription (1/2)

  Duncan, N. W.

  6/1/16 → 5/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展一新型藥物作為改善肥胖及肥胖引發糖尿病導致腎病變症候群之轉譯醫學研究(3/3)

  Lin, H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 有機鈀金屬促進關鍵抗腫瘤片段的縫合以建構雙功能抗癌化學結構(1/3)

  Liou, J.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Modulation of Cell Reprogramming to Pluripotency by Complex Surface Nanotopographies

  Wang, P.

  11/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展三功能抗體(EGFR/CD3/mPEG)修飾之聚乙二醇-免疫增敏奈米藥物以主動標靶毒殺大腸癌並同時強化體內T細胞於腫瘤微環境抗癌功效之創新協同療法-開發三功能抗體(EGFR/CD3/mPEG)以協同加成聚乙二醇-免疫增敏奈米藥物及T細胞於大腸癌腫瘤微環境之抗癌功效(2/3)

  Lin, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建構定量系統生理基礎藥動模型以評估腸道菌叢對口服藥物代謝影響及協助奈米膠體處方之開發(1/3)

  Hsieh, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 科技創新研發大數據資料庫建置計畫

  Shia, B.

  3/1/16 → 2/28/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluate the Radio-Biological Roles of miR-17-5P in Oral Cancer Cell Line OC3

  Wu, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討不同選擇作用之組織蛋白去乙醯酶調節成分抑制神經發炎之機制及其對腦內出血與腦炎之治療特性評估(1/3)

  Hsiao, G.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Publication of Journal of Biomedical Science

  Chang, W.

  1/1/14 → 12/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Improved Nutrition Care on the Progress of Hemodialysis Patients

  Yang, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology