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• b - Ministry of Science and Technology

  Drug Discovery and Pharmacological Investigation of Selective Hdac1 and 2 Inhibitors as Novel Anticancer Drugs

  Pan, S.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone 100%
  • Antitumor 34%
  • Antineoplastic Agent 33%
  • Drug 29%
  • DNA Sequence 19%

• 利用跨顱交流電刺激影響腦波頻率與相位差探討視覺記憶歷程的神經機制

  Tseng, P.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Publication of Journal of Biomedical Science

  Chang, W.

  1/1/19 → 12/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Imapct of Oxidative Stress on the Pathogenesis of COPD---An Ivestigation into Its Relationship with Abnormal Inflammation, DNA Instability, Epigenetics and Cell Metabolism

  Lee, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Tmu/Nih Integrated Research Project (4-3)─ Establishment of Image Diagnosis of Mild Traumatic Brain Injury by Functional Neuroimaging

  Chen, C. & Chiang, Y.

  8/1/11 → 1/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Traumatic Brain Injury 16%
  • N-nitrosoiminodiacetic acid 14%
  • Taiwan 8%
  • Wounds and Injuries 7%
  • Animal Models 7%

• The Roles of Micrornas in Endothelin-1 and Hypoxia-Induced Ctgf Production

  Chen, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • Endothelin-1 59%
  • Hypoxia 31%
  • Fibrosis 29%
  • Lung 23%

• The Effects of Neurofeedback and RSA Biofeedback on Quality of Sleep in Patients in the Chronic Phase of Traumatic Brain Injury

  Tsai, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sleep Initiation and Maintenance Disorders 100%
  • Respiratory Sinus Arrhythmia 86%
  • Traumatic Brain Injury 81%
  • Chronic Brain Injury 78%
  • Sleep 74%

• Effects of Glutamine on Inflammatory Response and Organ Injury in Diabetic Condition with Sepsis

  Chiu, W., Hsieh, R. & Yeh, S.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glutamine 100%
  • Sepsis 54%
  • PPAR gamma 22%
  • Nitric Oxide 16%
  • Wounds and Injuries 16%

• Design and Development of Antibody-Targetable and Self-Assembled Micelles of Anticancer Drug Conjugate and Complex of Hyaluronic Acid

  Sheu, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Micelle 100%
  • Hyaluronic Acid 73%
  • Doxorubicin 53%
  • Drug 40%
  • Complexation 29%

• Development of the Balance Tele-Rehabilitation System with Virtual Reality and Functional Electrical Stimulation

  Chen, S.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Patient rehabilitation 100%
  • Virtual reality 54%
  • Accelerometers 25%
  • Feedback 16%
  • Information science 12%

• Dissected the Role of Thrombomodulin in the Clinical Diagnostic and Therapeutic Impacts for Breast Cancer and the Regulation Mechanisms

  Hung, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Thrombomodulin 100%
  • Breast Neoplasms 90%
  • Therapeutics 20%
  • Neoplasms 12%
  • Steroid Receptors 11%

• Development of Taiwan Fall-Risk Screening Tool for Community-Dwelling Older People and a Randomized Controlled Trial of Fall Prevention in the Cognitively Impaired

  Lin, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Accidental Falls 100%
  • Taiwan 24%
  • Cognitive Dysfunction 20%
  • Risk Assessment 15%
  • Independent Living 12%

• Developing Artificial Intelligence and Iot Technology on Precision Sleep Medicine( I )

  Liu, W.

  1/1/18 → 12/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展以同步量測中樞與周邊系統功能性訊息為導向之年長跌倒患者步態復健評估(3/3)

  Chan, W. P.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 本研究擬探討高度糖化終產物及其前驅物甲基乙二醛誘發腎臟與內皮功能損傷之負 面效應，並釐清該損傷機轉是否與活化發炎體有關；此外，另探討白藜蘆醇之介入是否對 於上述損傷具有保護作用。第一部分實驗以高度糖化終產物接受器抑制劑釐清腎臟中高度 糖化終產物接受器的表現是否和發炎體路徑的活化有關，此外評估不同種高度糖化終產物 對於小鼠腎功能之影響。第二部分實驗則以高度糖化終產物接受器抑制劑證實抑制受器和 高度糖化中產物之交互作用是否可達到減少自由基產生進而抑制發炎體的活化以減緩發 炎反應所造成的腎損傷。第三部實驗分則觀察白藜蘆醇對於以高度糖化終產物前驅物MG 誘發腎損傷之影響並釐清白藜蘆醇是否可透過影響發炎體的活化達到延緩腎臟受損的作 用。研究預期長期高度糖化終產物和其前驅物‐甲基乙二醇的投與會使高度糖化終產堆積 在腎臟，也可能經由與其接受器結合進入細胞中活化發炎體路徑使腎臟發炎，使腎臟和內 皮功能損傷。因此減少暴露於高度糖化終產物的環境下或是抑制其接受器的作用皆可抑制 發炎體的活化達到延緩腎損傷的作用，且白藜蘆醇的介入對於上述損傷可能具有保護作用。

  Chen, J.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Receptor 100%
  • Activation 91%
  • Oxidative Stress 74%
  • Mouse 49%
  • Pathway 46%

• Effects of Iron and Onion Supplementation on Advanced Glycation End Products Metabolism in Obese Rat Model

  Chang, J.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • fatty liver 100%
  • iron 67%
  • onions 46%
  • metabolism 40%
  • advanced glycation end products 33%

• Decellularized Lymph Node Scaffold Vaccine Seeded with Dendritic Cells for Inducing Specific Antitumor Immunity

  Liu, D.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Dendritic Cells 100%
  • Lymph Nodes 61%
  • Immunity 30%
  • Neoplasms 28%
  • Neoplasm Antigens 26%

• 交通空氣污染與健康成年人心血管健康效應之相關性研究

  Chuang, K.

  9/5/17 → 9/4/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Niche Inflammatory Cytokine and Epigenetic Regulation in Expressions of Pluripotent Transcription Factor Oct4 and Sorafenib Refractoriness in Hbv-Related Hepatocellular Carcinoma and Its Clinical Implication.( II )

  Huang, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Interactions between Female Sex Hormones and Folic Acid

  Lee, W.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • folic acid 100%
  • sex hormones 66%
  • neoplasms 21%
  • in vivo studies 15%
  • estrogens 12%

• Surgical Decision-Making Process, Providing Information on the Decision-Making Process, the Impact of Physical and Mental Health for Spinal Surgery Patients

  Lin, P.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • surgery 100%
  • pain 77%
  • decision-making process 44%
  • anxiety 40%
  • interview 34%

• Development of Novel HDAC Inhibitors from Natural Products and Studies on Their Biological Activities

  Huang, W.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hydroxylysine 100%
  • Histone 34%
  • Acetylation 21%
  • Modification 17%
  • Occurrence in Nature 17%

• To Study the Role of Pctk1 in the Progression of Colorectal Cancer and Molecular Mechanism

  Wei, P.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • colorectal neoplasms 100%
  • neoplasms 54%
  • therapeutics 39%
  • metastasis 39%
  • death 31%

• Pharmacological Investigations and the Study of the Potential Biological Effects of Nitric Oxide Releasing Nano-Carrier System in Blue Light Induced Retinopathy( I )

  Cheng, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Issues and Rules in Public-Private Partnership for Vaccines Innovation

  Lee, C.

  1/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Vaccination 100%
  • Vaccine 96%
  • Public-private Partnerships 22%
  • Government 19%
  • Pharmaceuticals 18%

• A Clinical Correlation study of DNA Methyltransferases Alterations in Breast Cancer and Evaluation of DNA Methyltransferases as a Therapeutic Target in Cell and Animal Models

  Lin, R.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Tumor Suppressor Genes 95%
  • DNA (Cytosine-5-)-Methyltransferase 1 67%
  • Methyltransferases 40%
  • DNA Methylation 35%

• The Effect of Muscle Strength Training on Body Composition and Sarcopenic Obesity among the Female Overweight Elderly

  Liou, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • medication 100%
  • study group 58%
  • Group 52%
  • Taiwan 48%
  • expert 36%

• Study of Postoperative Adverse Outcomes of Surgical Patients Using Taiwan National Health Insurance Database

  Chen, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Anesthesia 100%
  • Postoperative Complications 87%
  • Databases 61%
  • National Health Programs 53%
  • Taiwan 50%

• The Studies on the Mechanism of Intravenous Immunoglobulin (Ivig)-Induced Inhibitory Functions on Neutrophil Recruitments

  Chang, J.

  8/1/12 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Intravenous Immunoglobulins 100%
  • Leukocyte Rolling 38%
  • Leukocytes 25%
  • Neutrophil Infiltration 23%
  • E-Selectin 12%

• Development of Targeted Cancer Agents Using a Naturally Occurring Scaffold and Knowledge-Based Design

  Huang, W.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone 100%
  • Antitumor 25%
  • Antiproliferative 18%
  • Antineoplastic Agent 16%
  • Osthole 16%

• Gene Signatures and Potential Therapeutic Targets of Amino Acid Metabolism in Estrogen Receptor-Positive Breast Cancer(1/2)

  Wang, C.

  1/1/20 → 12/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Anoikis 60%
  • Breast Neoplasms 60%
  • Amino Acids 58%
  • TOR Serine-Threonine Kinases 34%
  • tamoxifen acid 21%

• 配對式神經調控模式應用於脊髓損傷者之前瞻神經復健技術開發-子計畫三：運用跨模態多項次神經影像技術探討神經調控模式對脊髓損傷者之神經可塑性與功能變化(2/3)

  Chan, W. P.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 配對式神經調控模式應用於脊髓損傷者之前瞻神經復健技術開發-子計畫一: 在脊髓損傷動物模式下探討配對式神經調控之作用機制與療效(2/3)

  Peng, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 神經纖維瘤之腫瘤微環境與潛在治療標的(1/2)

  Liao, C.

  1/1/21 → 12/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• New Strategy in Natural Product Research---A Rapid Analysis and Rapid Activity Screening Platform

  Lee, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • screening 100%
  • bioactive compounds 99%
  • environmental protection 43%
  • endophytes 36%
  • animal models 31%

• The Application of Polypropylene Mesh in the Anatomical Correction and Functional Improvement of Pelvic Floor Disorders---Morphological and Functional Exploration

  Yang, J., Yang, S. & Huang, W.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • urethra 100%
  • urinary incontinence 60%
  • surgery 54%
  • polypropylenes 35%
  • fascia 24%

• To Identify Whether Ion Conductance Dysfunction Is an Early Electrophsiological Biomarker of Polyneuropathy in Diabetic Patients: a Longitudinal Study of Nerve Excitability in Diabetic Patients

  Sung, J.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neural Conduction 100%
  • Diabetic Neuropathies 69%
  • Ions 24%
  • Biomarkers 19%
  • Polyneuropathies 17%

• The Use of Organometallic Reaction in the Syntheses of Anticancer Agents(2/2)

  Liou, J.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Txnip in Skewing Alveolar Macrophages towards M1/M2 Polarization: Implication for the Pathogenesis of Chronic Obstructive Pulmonary Disease(1/3)

  Chen, C.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Investigate the Role of Acid Sensing Ion Channels in Hypertrophy of Human Lumbar Ligamentum Flavum

  Lee, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建置與評估可擴充式機器學習演算法之重症醫療資訊平台

  Lo, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Antrodia Camphorate Extract on Diet-Induced Steatohepatitis

  Chen, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Antrodia 100%
  • liver diseases 34%
  • inflammation 31%
  • extracts 27%
  • fatty liver 21%

• 長鏈非編碼缺氧誘發核醣核酸 LncHIFCAR之內含性微小核糖核酸miR- 31在胰臟癌進程的功能性角色

  Shih, J.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 比較不同血液透析中央靜脈導管設計（階梯型、分岔型、對稱型）之臨床應用成效

  Tam, K.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 奈米HEVnp於晚期大腸直腸癌患者的治療策略(2/3)

  Whang-Peng, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Benefical Effects and Mechanisms of Probiotics and Exercise Intervention Strategies in 6-Ohda Induced Parkinson'S Disease Rat(1/3)

  Huang, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Probiotics 100%
  • Oxidopamine 81%
  • Parkinson Disease 39%
  • Substantia Nigra 25%
  • Gastrointestinal Microbiome 23%

• Exploring the Potential Applications of Dna Mimic Protein Saugi in Viral Diseases and Mrsa by Structure-Based Study

  Wang, H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Uracil-DNA Glycosidase 100%
  • Simplexvirus 47%
  • Staphylococcus aureus 37%
  • vpr Gene Products 35%
  • Human Immunodeficiency Virus Proteins 29%

• Disease Trajectories and Its Association with Metabolic Dysfunction of Prostate Cancer Men Following Androgen Deprivation Therapy and the Potential of Pharmacological Medication in Preventing Metastatic Diseases.

  Shao, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploring the Potential Impacts of Maternal Early-Life Sleep Deprivation on Metabolic Function of the Offspring( II )

  Chang, H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 選擇性抗癌標靶藥物HDAC6抑制劑臨床前試驗研究

  Pan, S.

  12/1/17 → 10/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology