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• b - Ministry of Science and Technology

  A Preclinical and Clinical Trial Evaluation for an in vitro Diagnostic Kit of Endometriosis (II)

  Yang, W.

  12/1/13 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Structural Modification of Terpenoids and Biological Evaluation on Immunoinflammation

  Lin, S.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Therapeutic Effects of New Derivatives of Thalidomide and p53 Inhibitors in Acute Traumatic Injury---Dosing Regimen, Routes and Multiple Mechanism

  Wang, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development and Application of Black Soy Bean Koji on Elderly Protein Nourishment( III )

  Huang, H.

  5/1/19 → 5/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• miR-103/107在大腸癌幹性中所扮演的角色探討

  Chen, H.

  4/1/16 → 9/30/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 甲狀腺荷爾蒙調控腸上皮細胞屏障與通透性的角色探討-針對甲狀腺影響腸道作用之路徑研究

  Lin, J.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 香豆素衍生物於KRAS突變大腸癌與5- fu抗藥性癌細胞之治療及機轉研究

  Cho, E.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 金融知識與金融風險應變能力之研究-Covid-19疫情為例

  Hsiao, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 開發可標靶樹突細胞之負載新型冠狀病毒棘狀蛋白的醣化PLGA奈米顆粒在小鼠中引起有效的免疫原性之研究

  Sheu, M.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Anti-Α9nachr/Anti-Polyethylene Glycol Bispecific Antibody to Enhance the Therapeutic Efficacy of Nano-Drugs against Breast Cancer(II)(2/3)

  Chuang, K.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Jet Lag as a Potent Manipulator of Mood(1/2)

  Myung, J.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Associated Factors of Smoking around School-Aged Children and the Intervention Development Using the Theory of Reasoned Action

  Chen, P. & Shiau, F.

  8/1/10 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Blood Sugar Regulation and Molecular Mechanism by White Potato Extract

  Li, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Different Sources of n-3 Fatty Acids on Bone Loss, Body Fat and Inflammatory Markers in Osteoporotic Condition with Diabetes

  Chiu, W. & Fong, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Neuroimage Biomarker of Thalamo-Cortical Network for Outcome Prediction in Mild Taumatic Brain Injury: a Translational Mri Research

  Lu, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Targeting and Blockades of Advanced and Metastatic Breast Cancer with Trispecific or Dual Bispecific Antibodies Non-Covalently Bound on Mpegylated Nanocarriers Loaded with Docetaxel and Pictilisib for Synergistic Therapy and Circumventing the Resistance

  Sheu, M.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating the Role of Ck1 Delta in Tumor Progression, and as a Therapeutic Target for New Drug Discovery in Bladder Cancer.

  Chen, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Interaction between Gut and Brain in High-Functioning Autism: from Phenotypes to Specific Imaging Endophenotypes

  Lo, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 辨認癌化過程中 adenosine至inosine RNA編輯的調控因子

  Chen, C.

  10/1/16 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies of the Vegetable Components on Menopausal Obesity and the Associated Mechanisms

  Chen, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Repositioning Drug Therapies for Traumatic Brain Injury

  Chiu, W., Chang, C. & Chiang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of the Relationships among Anti-Obesity Activity, Adipogenesis, and Adipose Angiogenesis of Vegetable Indolic Derivatives---Involvement of the Ah Receptor/Arnt ? (II)

  Chen, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Chief Digital Officer in Commerical Bank Stratgies and Performance

  Hsiao, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Cortical Electrical Stimulation Technique for Improving Neuroplasticity and Motor Function in Parkinsonian Rats

  Hsieh, T., Chiang, Y. & Peng, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Design and synthesis of novel dual EZH2 and HSP90 inhibitor

  Liou, J.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 脂質薑黃素顆粒(SLCP)在體內對mTOR訊息路徑的作用–尋求以疾病機制為基礎對結節性硬化症(TSC)癲癇的治療策略(1/3)

  Lee, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of the Relationships among Anti-Obesity Activity, Adipogenesis, and Adipose Angiogenesis of Vegetable Indolic Derivatives---Involvement of the Ah Receptor/Arnt ?(III)

  Chen, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 台灣醫護人員於新型冠狀肺炎疫情期間之心理健康狀況研究--以台北某醫院為例

  Liou, T.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 產學合作計畫－以體外擴增循環腫瘤細胞系統預測腫瘤治療反應(1/2)

  Lu, L.

  6/1/20 → 5/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 闡明Hiltonol在非小細胞肺癌中主導的抗癌機轉

  Chang, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 結合奈米診斷治療、影像免疫基因圖譜與人工智慧於原發性與再復發膠質母細胞瘤之研究-建立原發性和再復發膠質母細胞瘤免疫圖譜以及建立免疫療法(2/3)

  Lee, G.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建置公衛研究專用之衛星遙測影像環境資料自動化平台

  Chuang, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 產學合作計畫－產學研發中心計畫—微整型生醫材質產學研發中心(1/3)

  Sheu, M.

  7/1/20 → 6/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Function and Regulation of Mirnas in Pancreatic Cancer Progression( III )

  Huang, M.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展三功能抗體(EGFR/CD3/mPEG)修飾之聚乙二醇-免疫增敏奈米藥物以主動標靶毒殺大腸癌並同時強化體內 T 細胞於腫瘤微環境抗癌功效之創新協同療法-發展新型聚乙二醇-免疫增敏奈米藥物載體以毒殺大腸癌並強化腫瘤區域T細胞之抗癌功效(1/3)

  Liu, D.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Implication of Plasminogen Activator Inhibitor-1 in the Regulation of Thrombin-Induced Fibrogenesis in Inflammatory Pleural Effusions.

  Chung, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Using the Integrated Hospital Data for Implementing and Evaluating of Early Detection of Influenza Epidemic

  Lo, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies of Folic Acid-Induced Anti-Tumor Growth Activity---Anti-Angiogensis and Anti-Cancer Cell Growth

  Lee, W.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating a key switch between immune-overactivation and tumorigenesis

  Chang, S.

  2/1/16 → 1/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Aging Effect on the Progression of Restenosis: Establishment of the Platform for Screening the Drugs Targets with Suppressing Effect on Platelet-Derived Growth Factor Receptor-Beta

  Wu, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Efficient Immunoglobulin G Analytical Method for Investigating Autoantibody Biomarkers for Pancreatic Disease (Continuous Research)

  Tsai, I.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of Metabolic Abnormality on Dna Methylation in Schizophrenia: the Role of One-Carbon Metabolism

  Lu, M.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Injectable and partially biodegradable polymethylmetacrylate-based bone cement for vertebroplasty

  Yang, K.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 評估以慢性病病人用藥經驗理論為基礎之藥病溝通策略：混合方法研究

  Chang, E. H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Investigate Sema7a+ Regulatory T Cells in Type 2 Immune Responses towards Pulmonary Fibrosis(1/3)

  Chen, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討檸檬香蜂草水萃物誘導大腸癌細胞鐵依賴性細胞死亡之抗腫瘤機轉

  Huang, T.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 評估 SSRI 抗憂鬱藥物 sertraline 及 paroxetine 對正常與阿茲海默症高危險群老年人的影響

  Shen, S.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 合成劇噻吩石墨烯智慧型基材以建立仿神經元微環境來探討癌症引發之周邊神經侵犯研究

  Huang, W.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Smart Microtube Array Membrane Scaffold for Nerve Regeneration---Fabrication, in vitro and in vivo Evaluation

  Chen, C.

  8/1/13 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology