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• b - Ministry of Science and Technology

  A Care-Based Innovative Networking for Active Ageing( II )

  Lin, C.

  7/1/17 → 6/30/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Decellularized Plant Extracellular Matrices as a Scaffold for Tissue Engineering(2/2)

  Tseng, H.

  8/1/18 → 8/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • extracellular matrix 100%
  • animal tissues 65%
  • tissue engineering 44%
  • porometers 29%
  • polyglutamic acid 28%

• Neurodegenerative Diseases( I )(1/3)

  Shen, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Tmu/Nih International Collaboration Study – Translational Research on Memory Reserve against Traumatic Brain Injury

  Chang, W.

  10/1/19 → 12/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Connectome 100%
  • Traumatic Brain Injury 77%
  • Memory 40%
  • Brain 31%
  • Animal Models 17%

• Development and Application of Hospital Adverse Events Database and Management Information System

  Chung, M.

  11/1/19 → 10/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Management information systems 100%
  • Decision trees 78%
  • Information management 74%
  • Big data 72%
  • Personnel 61%

• Characterize the E3 Ligase Activity of Znf179 and Its Effect on the Proteinopathies of TDP-43 Protein

  Huang, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Ubiquitin-Protein Ligases 100%
  • TDP-43 Proteinopathies 61%
  • Amyotrophic Lateral Sclerosis 47%
  • Frontotemporal Lobar Degeneration 36%
  • Proteins 32%

• Self, Consciousness, and Neurophilosophy

  Lane, T. J.

  1/1/13 → 12/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• In vitro and in vivo Evaluation for Silk Fibroin-Coated Electrospun Resorbable Poly(Lactic Acid) GTR Barriers

  Yang, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Surface 100%
  • Application 98%

• Infant Feeding Information in the Internet and How the Information Influences the Infant Feeding Behavior

  Chen, Y. C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Infant Feeding 100%
  • World Wide Web 20%
  • Child nutrition 9%
  • Taiwan 9%
  • Children's Health 8%

• The Effect of Wnt Signals and Programmed Cell Death on the Organization of Neural Circuit in Spinal Motor Neurons

  Kao, T.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Motor Neurons 100%
  • Wnt Receptors 73%
  • Ephrins 46%
  • Nerve Growth Factors 42%
  • Growth Cones 40%

• The Functional Role of Pdk1 in Arnt Oncogene-Regulated Tumorigenesis and Tumor Progression

  Chang, W.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neoplasms 100%
  • Enzymes 90%
  • Carcinogenesis 47%
  • Oncogenes 39%
  • Neoplasm Metastasis 38%

• 抗發炎藥物與生物製劑藥物對類風濕性關節炎病人發生惡性腫瘤之影響：健保資料庫分析研究

  Chen, S. H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Tumor Necrosis Factor Inhibitors 100%
  • National Health Programs 86%
  • Drug-Related Side Effects and Adverse Reactions 76%
  • Pharmaceutical Preparations 56%
  • Rheumatoid Arthritis 45%

• 生命科技群組政府科技發展計畫規劃及審議之研究

  Chang, W.

  1/1/15 → 12/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Explore of Toll-Like Receptors Associated Mirna Expression in Ischemic Stroke Patients (I)

  Wu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the Carcinogenic Mechanisms of Glucose Transporters in Gastrointestinal Cancer Cells and Its Clinical Therapeutic Applications(2/2)

  Chen, L.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glucose 100%
  • Antitumor 19%
  • Occurrence in Nature 17%
  • Pharmacological Metabolism 11%
  • Biological Role 8%

• Studies on the Molecular Mechanism of Thrombin-Induced Connective Tissue Growth Factor (CTGF) Expression in Lung Fibroblasts

  Lin, C.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Connective Tissue Growth Factor 100%
  • Thrombin 61%
  • Fibroblasts 24%
  • MAP Kinase Kinase Kinase 5 20%
  • Transcription Factor AP-1 18%

• Development of Novel Dyrk1a Inhibitors for the Treatment of Alzheimer'S Disease

  HuangFu, W.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Dyrk kinase 100%
  • Alzheimer Disease 43%
  • Neurofibrillary Tangles 17%
  • Amyloid beta-Peptides 15%
  • Memory 10%

• Anticancer Drug Discovery of New Tegafur-Derivatives for Colorectal Cancer Therapy

  Chen, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Colorectal Neoplasms 47%
  • Survival Rate 15%
  • HCT116 Cells 12%
  • Neoplasms 11%
  • Prodrugs 11%

• A Investigation of CCL5 (Rantes) in Neurogenesis Mechanism

  Chou, S.

  2/1/14 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neurons 100%
  • AMP-Activated Protein Kinases 83%
  • Chemokine CCL5 58%
  • Axons 50%
  • Glycogen Synthase Kinases 44%

• 可卡因促使Sig-1R局部化於核膜與emerin-HDACs抑制因子複合物結合來調節MAOB表達(3/3)

  Chuang, J.

  8/1/16 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • sigma-1 receptor 100%
  • Cocaine 59%
  • Monoamine Oxidase 42%
  • emerin 30%
  • Co-Repressor Proteins 23%

• Building The Big Data Database of Technological Innovation, Research and Development (Ⅱ)

  Shia, B.

  3/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Blood Sugar Regulation and Molecular Mechanism by White Potato Extract

  Li, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • blood glucose 100%
  • sweet potatoes 75%
  • diabetes 59%
  • noninsulin-dependent diabetes mellitus 53%
  • insulin resistance 51%

• Novel Roles of Aryl-Hydrocarbon Receptor ((AhR) on Epigenetic and Post-Translational Modification of Cell-Cycle Regulatory Genes and Enos in Vascular Endothelial Cells---The Therapeutic Potential of Resveratrol/Statins

  Juan, S. & Hwang, L.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Aryl Hydrocarbon Receptors 100%
  • Phosphatidylinositol 3-Kinases 25%
  • cdc Genes 24%
  • Epigenomics 22%
  • Umbilical Cord 22%

• Explore the Prevalence of Sarcopenia among Elderly and the Effect of Health Promotion Program

  Hung, Y. & Tseng, I. J.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sarcopenia 100%
  • Elderly 40%
  • Taiwan 29%
  • Health Promotion 19%
  • Exercise 19%

• 即時移動污染源自體排放超細懸浮微粒之車載毒性測試平台建立與應用評估

  Chuang, H.

  9/5/17 → 9/4/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Functional Materials Using Atomic Layer Deposition and Their Applications in Green Energy Technology: Solar Cells, Hydrogen Production via Water Splitting, and Supercapacitors

  Chang, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Atomic Layer Epitaxy 100%
  • Green 37%
  • Energy 30%
  • Solar Cell 18%
  • Nanorod 18%

• Pank2 Mutations and the Neurodegeration: Investigating the Pathogenetic Mechanisms and Identifying the New Treatment

  Hong, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Translational Characterization of the Role of Wnt/Beta-Catenin/Tcf Signaling in the Generation of Invasive and Chemoresistant Cancer Stem Population in Liver Cancer

  Lee, W. & Yeh, C.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neoplastic Stem Cells 100%
  • Liver Neoplasms 85%
  • beta Catenin 71%
  • Side-Population Cells 47%
  • Drug Resistance 14%

• Macro and Micro Biomechanical Studies of Soft Tissue Remodeling under Tissue Expansion

  Chen, H.

  8/1/11 → 11/30/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • tissues 100%
  • skin (animal) 31%
  • mechanical properties 29%
  • animal injuries 22%
  • clinical trials 21%

• Relationships of One-Carbon Cycle Pathways with Psychopathology and Metabolic Abnormalities in Patients with Schizophrenia and Potential Intervention Strategy with 5-Methyltetrahydrofolate and Vitamin B12

  Chen, C., Huang, S. & Lu, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Folic Acid 100%
  • Vitamin B 12 69%
  • Carbon Cycle 66%
  • Schizophrenia 51%
  • 5-methyltetrahydrofolate 48%

• Investigation of the molecular mechanisms of a novel finger protein, ZNF179, in neuronal differentiation

  Lee, Y.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Cell Cycle Checkpoints 100%
  • Proteins 94%
  • Knockout Mice 94%
  • Cell Differentiation 83%
  • Cell Cycle Resting Phase 62%

• Dementia Care and Quality Improvement

  Chien, L.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • dementia 100%
  • health insurance 28%
  • Medical records 19%
  • utilization 17%
  • resources 9%

• Effects of Long-Term Exposure to Indoor Air Pollution and Indoor Air Quality Improvement on Cardiovascular Health in General Population

  Chuang, K.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Indoor Air Pollution 100%
  • Quality Improvement 18%
  • Health 15%
  • Air Pollution 14%
  • Taiwan 12%

• Prostate Cancer Malignancy Is Enhanced by Glycotoxins

  Wu, C. & Hsia, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Receptor for Advanced Glycation End Products 100%
  • Prostatic Neoplasms 40%
  • Neoplasms 22%
  • Autophagy 16%
  • Amino Sugars 13%

• Neurovascular Dysfunction in Post-Stroke Cognitive Impairment(2/3)

  Hu, H.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Antitumor Activity and Pharmacological Mechanisms of Pik3c3 Inhibitor in Bladder Cancer Cells

  Chen, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Urinary Bladder Neoplasms 100%
  • Autophagy 72%
  • Endosomes 31%
  • Cachexia 23%
  • Phosphatidylinositol 3-Kinases 18%

• Study on the potential anti- pulmonary fibrotic effect of desmethylclomipramine

  Chen, C.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Utilizing the Translational Approach to Investigate the Molecular Mechanism Underlying H2afj-Promoted Temozolomide Resistance in Glioblastoma Multiforme

  Lee, H.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 比較外用ivermectin與metronidazole於低蟲量酒糟患者的臨床療效

  Wang, H.

  11/1/20 → 10/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Expressing Membrane Antibody Reporter in the Islet Cells of Nonobese Diabetic Mice to Noninvasive Image the Disease Progression of Autoimmune Diabetes and the Therapeutic Effects of Drugs or Transgenes

  Chuang, K.

  11/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • islets of Langerhans 100%
  • image analysis 98%
  • mice 95%
  • pins 80%
  • drugs 39%

• Model Construction of the Relationships among Mental Fatigue, Cognitive Functions, and Return to Productive Activity in Patients with Traumatic Brain Injury.

  Chiu, H.

  12/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploring Gene-Lifestyle Factors of Childhood Obesity, Pubertal Development, and Insulin Resistance(2/3)

  Chen, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Novel Porcine Bone Xenograft Development

  Chang, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • bones 100%
  • dentistry 66%
  • testing 36%
  • skeletal development 31%
  • biocompatibility 27%

• The Evaluation of the Long-Term Effects of Interpersonal and Social Rhythm Therapy on Sleep and Social Functioning in Patients with Bipolar Disorder

  Chung, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sleep 100%
  • Bipolar Disorder 93%
  • Depression 42%
  • Periodicity 35%
  • Therapeutics 28%

• Tumor Necrosis Factor-Alpha Induces Airway Hypersensitivity: Role of Ceramide

  Hsu, C.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Ceramides 100%
  • Hypersensitivity 61%
  • Sensory Receptor Cells 60%
  • Lung 35%
  • sphingosine 1-phosphate 24%

• Molecular mechanisms of alpha9-nicotinic acetylcholine receptor (alpha 9-nAChR)-mediated Trastuzumab (HerceptinR) drug resistance in breast cancer cells

  Ho, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Liposomes 66%
  • MicroRNAs 56%
  • Trastuzumab 53%
  • Nicotinic Receptors 49%

• The Investigation of the Role Secretogranin 3 in the Development of Insulin Resistance and the Related Mechanisms

  Wu, H.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • secretogranin III 100%
  • Insulin Resistance 22%
  • Autophagy 11%
  • Glucose 9%
  • Lung Neoplasms 6%

• Longitudinal Analysis Combining Neuroimage and Proteomic Studies on Fibromyalgia Patients

  Kang, J.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 奈米HEVnp於晚期大腸直腸癌患者的治療策略(2/3)

  Whang-Peng, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Investigate the Mode of Galectin-1 and Neuropilin-1 Interactions in Carcinoma-Associated Fibroblasts and Its Implications in Oral Cancer Therapy

  Wu, M.

  8/1/15 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neuropilins 100%
  • Fibroblasts 91%
  • Polysaccharides 77%
  • Carcinoma 72%
  • Mouth Neoplasms 22%