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Finished
Investigation on the Suppressive Mechanisms of Novel Anti-Glypican3 Antibody Drugs
8/1/14 → 7/31/16
Project: A - Government Institution › b - Ministry of Science and Technology
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Antibody-Mediated Immune Suppression of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Study the Function and Regulation of miRNAs in Pancreatic Cancer Progression (I)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Different Sources of n-3 Fatty Acids on Bone Loss, Body Fat and Inflammatory Markers in Osteoporotic Condition with Diabetes
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Indoor Air Quality Improvement on Cardiovascular Health in General Population
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Study of the Relationships among Anti-Obesity Activity, Adipogenesis, and Adipose Angiogenesis of Vegetable Indolic Derivatives---Involvement of the Ah Receptor/Arnt ?(III)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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氧化還原作用調控蛋白質去磷酸酉每羰基化和去羰基化反應對動脈血管內膜增生之影響(1/2)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Natural Product Hybrid and Ortho-Biaryl N-Hydroxycinnamide as Leads for Anticancer Agent Development
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Trends in Surgical Litigation and Media Coverage of Medical Malpractice: Implications for Medical Education
Lyu, S.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Promoting Healthy Eating---A Family-Centered Obesity Prevention Randomized Control Trial for Preschool Children
8/1/14 → 10/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Exploratory Study of Self-Identity and Medical Professionalism among Medical Students (II)
8/1/14 → 12/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effect of Long Acting GnRH Agonist Treatment on Mitochondrial Function in
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Detecting Genetic Variants Based on a Random-Effects Model
Cheng, K.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Research on Development of Clound Computing Platform for Decision Support Systems Healthcare by Healthcare Big Data and Analytics
Chiang, I.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Down-Regulation of RanGAP Augments Nucleus BCR-ABL Level to Potentiate the Drug Efficacy of Imatinib in Chronic Myelogenous Leukemia
8/1/14 → 10/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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To Study the Correlation between Serum Markers of Oxidative Stress, Inflammation, and Endocrine-Disrupting Chemicals (Edcs) and Their Impact on the Menstrual Cycle and Reproductive Hormone in Taiwanese Women.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Analysis the Role of Satellite Cell during Denervation Induced Muscular Atrophy and a Trail of Transplantation of Adipocyte Derived Myogenic Stem Cells
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effectiveness of an Intervention of Leader Empowering Behaviors to Reduce Staff Nurse Turnover Rate in Long-Term Care Settings
8/1/14 → 10/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Arsenic Methylation Capacity, Methylenetetrahydrofolate Reductase and Dna Methylation Gene Polymorphisms, Plasma Selenium Concentration and Selenoprotein Gene Polymorphisms and Renal Cell Carcinoma
Hsueh, Y.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Influence of Porphyromonas gingivalis Groel in Vascular Cells
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Direct Renin Inhibitor on Visceral Adipose Tissue and Vascular Remodeling of Fructose-Fed Hypertensive Rats
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Central Neuromodulation with Functional Electrical Stimulation on Bladder Functions in Traumatic Brain Injured Rats
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Dissected the Role of Glucosed-Regulated Portein 78 in the Progression, Metastasis and Therapy of Colorectal Cancer
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Emerging Mechanisms of Omega-3 Fatty Acids in Depression---The Effects of EPA and DHA on Chronic Stress, Neurogenesis and Neuroinflammation
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Determined the Role and the Mechanims of GRP94 in Mediating the Progression and Therapeutic Responses of HCC
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Application of Regioselective Substitution on 1,4-Benzoquinone Derivatives to Provide Potent Anticancer Agents
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Evaluation on Cervical Cancer Prevention and Treatment Policy in Taiwan
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Enhancement of Immuno-Modulatory Capacity by Shear Stress in Mesenchymal Stem Cells
Ho, J.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Effect of RRM2 in Tumor Metastasis and Chemotherapy Response of Colorectal Cancer Patients with Different APC and K-Ras Status
Cheng, Y.
8/1/14 → 7/31/16
Project: B - Project of TMU › i - Other (Funded by TMU)
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The Study of Therapeutic Effects for Stroke with Phenserine, an Amyloid Precursor Protein Inhibitor, in Rodent Focal Cerebral Ischemia Model(2/3)
Chang, C. & Chiang, Y.
8/1/14 → 7/31/15
Project: A - Government Institution › a - National Health Research Institutes
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Identification of Rewired APC Mutation Signaling Network in Chemotherapy Resistant Response in Colorectal Cancer (I)
8/1/14 → 10/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigate the Molecular Mechanisms Involved in Enhancing Photodynamic Thetapy Using an Old Antibiotic Agent
Tsai, T.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Studies on Combination of Hydrophobic Anticancer Drugs Encapsulated in Nanocarriers and Hydrophilic Anticancer Drugs Loaded in Thermosensitive Hydrogels into Cancer Cell
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Investigation of the Gutta Percha Temperature Change on Vertical Compaction of Warm Gutta Percha Technique
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigation of the Transcriptional and Epigenetic Mechanisms for the Nm23-H1 Expression---An Nm23-H1-Promoter Screening Platform for Novel Metastasis-Suppressing Anticancer Drugs
Wang, L.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Preclinical Evaluation of Application of Sclareol for Adjuvant Therapy of Cisplatin-Resistant Non-Small Cell Lung Cancer
8/1/14 → 9/30/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effect of Health Risk Behaviors on Recurrent Traffic Injury
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Exploitation of Taiwan Native Plants in Promoting Bone Growth and Establishment of the System Biology Platform
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Development of Cortical Electrical Stimulation Technique for Improving Neuroplasticity and Motor Function in Parkinsonian Rats
Hsieh, T.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Construction and Application of Spatio-Temporal Database and Geography Information System for Emergency Medical Care (I)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Study and Implementation of Patient Privacy Protection under the Framework for Electronic Medical Records Exchange in Taiwan
Liu, C.
8/1/14 → 10/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Prognosis Analysis and Data Mining for Emergency Patients after Arriving Hospital
Hsu, C.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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探討小泛素蛋白Sentrin-specific protease 2 參與轉型生長因子-beta訊息傳遞的作用機制(2/2)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Can Sesamin Alone or Cotheapy with Anti-DM Medicines Alleviate the Abnormal Intermediate Metabolites of Glucose and Fatty Acids, the Oxygen Consumption and Renal Fibrotic Progression?
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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ALA Photodynamic Therapy, Tumor Hypoxia, CSE1L Phosphorylation, and the Progression and Treatment of Skin Cancer
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Synaptic Plasticity by Nogo-1 Receptor Overexpression and Exendin-4 Administration on Behavioral and Electrophysiological Recovery after Mild Traumatic Brain Injury (III)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Studies on the Role of ORMDL3 in Thrombin-Induced IL-8/CXCL8 Expression and Airway Inflammation
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology