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  在具放射治療抗性神經膠質母細胞癌的細胞中尋找MicroRNA (miR-671-5p)控其高細胞移動特性、癌症幹細胞特性及遠隔效應，並搭配人工智慧軟體開發基因調控資料庫加強免疫治療策略

  Lin, J.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以深度學習技術增進從靜息態磁振造影評估腦血管反應性

  Chen, D. C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 天然物對兒童高惡性度神經膠質細胞瘤之治療潛力及其分子作用機轉探討(1/3)

  Chen, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 整合虛擬實境與穿戴式感測的智慧醫療抗認知衰弱研究

  Chang, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討牙周病對牛皮癬之影響與治療用藥策略性之研究

  Lee, A.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討YqiC蛋白特性以開發標靶抗生素並針對沙門氏菌抗生素抗藥性和侵襲性進行基因分析：以雙面向方法發展對抗沙門氏菌感染之新策略(3/3)

  Fang, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 魚類感覺系統在酸性環境下的功能變化-從側線到行為的探討(1/3)

  Horng, J.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展三功能抗體(EGFR/CD3/mPEG)修飾之聚乙二醇-免疫增敏奈米藥物以主動標靶毒殺大腸癌並同時強化體內T細胞於腫瘤微環境抗癌功效之創新協同療法-開發三功能抗體(EGFR/CD3/mPEG)以協同加成聚乙二醇-免疫增敏奈米藥物及T細胞於大腸癌腫瘤微環境之抗癌功效(2/3)

  Lin, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以智慧輔助科技介入失智症照護及其社會經濟影響－以智慧輔助科技介 入失智症照護及其社會經濟影響

  Chen, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 仿生與數位設計導向之絲蛋白纖維設計/合成/製造之轉譯研究(4/4)

  Yang, J.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 在國際健康功能與身心障礙分類系統的架構下，探討蛋白質補充合併運動訓練對急慢性機構衰弱老人改善肌少症指數及身體活動功能之成效(3/3)

  Liou, T.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 嗜伊紅性白血球陽離子蛋白衍生之細胞穿透胜肽對於調節過敏性發炎之研究- 促進STAT-6反義RNA之運送與表現(3/3)

  Lee, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以小分子甲殼素奈米粒子建構水生魚類的核酸運輸平台

  Cheng, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 飲食障礙症的死亡率和相關因子

  Tseng, M.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 芳香烴受體於眼科疾病之治療潛力機制探討-芳香烴受體於藍光誘發視網膜病變之治療潛力機制探討(2/3)

  Cheng, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 標題：謹慎設計抗胃癌藥物：結構簡化方法、骨架躍遷策略以及對二氧化矽負載的質子酸/路易斯酸催化的多組分反應以產生關鍵中間體的詳盡探索

  Nepali, K.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Aza-PBHA , 透過調控芳香烴受體於糖尿病視網膜病變治療潛力機制探討(2/3)

  Cheng, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 結合奈米診斷治療、影像免疫基因圖譜與人工智慧於原發性與再復發膠質母細胞瘤之研究-開發新穎結構小分子抑制劑用來抑制血管生成和腫瘤微環境以治療原發性及復發性多型性神經膠質母細胞腦瘤患者(3/3)

  Huang, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 結合精密儀器與資料庫和對接技術的天然物研究一一植物代謝體的應用及問題解決(1/3)

  Lee, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討由中草藥丹蔘衍生之單一化合物及微小核糖核酸494在肥胖引發糖尿病導致腎病變之轉譯醫學研究

  Chen, H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 遠紅外線改善骨骼肌和白色脂肪細胞胰島素阻抗的作用及其PLZF相關機制的研究(1/3)

  Chen, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立奈米載體之精準治療於心肌梗塞後心室重塑的臨床前評估(1/3)

  Shih, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討運動結合益生菌補充策略對巴金森氏症改善效果與可能機轉(2/3)

  Huang, H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用PLAG6 Knockin基因嵌入小鼠探討飲食用色胺酸補充策略對巴金森氏症病程發展及對色胺酸代謝路徑的影響(2/3)

  Huang, H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展具有靶向及溶解血栓功能的奈米藥物治療平台(2/2)

  Mi, F.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以代謝工程建立紫色桿菌素胞外生產系統與其連續式醱酵製程開發(1/3)

  Lin, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 最佳振動運動對於上肢肌力及功能提升之影響-以老化與神經損傷為探討

  Lin, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 癌因性口腔黏膜炎之精準健康照護：運用蜂製品之臨床隨機試驗

  Huang, T.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 配對式神經調控模式應用於脊髓損傷者之前瞻神經復健技術開發-子計畫三：運用跨模態多項次神經影像技術探討神經調控模式對脊髓損傷者之神經可塑性與功能變化(3/3)

  Chan, W. P.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 競爭性內源RNA-BC200調控網絡誘導腦瘤中嘌呤體形成之分子機制與臨床意義

  Lin, J.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討缺氧誘導之 lncRNA MIR210HG 在腦瘤惡性進程及促進 temozolomide 藥物抗藥性機轉中角色，並評估其作為腦瘤治療標的之可行性

  Chen, K.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以快速動眼期睡眠剝奪大鼠模型研究鋰鹽心臟保護作用、生理恆定負荷調節、及粒線體生物能量調控之分子機轉

  Chen, P.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 具抗纖維化效果之選擇性組蛋白去乙醯酶抑制劑：利用有機金屬耦合反應合成吡啶酮為骨架之系列衍生物

  Liu, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• β-catenin訊息路徑誘發動靜脈廔管病變之分子機轉: 預防動靜脈廔管狹窄之新型治療標的 (第二年延續計畫)

  Sue, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 酵素交聯水凝膠合併血小板裂解質應用於關節軟骨再生(1/3)

  Chen, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 具機械強度、可降解及骨誘導能力之鎂基非晶質合金應用於高位脛骨截骨矯正術之骨填充楔開發(2/3)

  Chen, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立國人電腦斷層脊椎椎體結構強度之預測模型

  Chen, H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 導入以案例為導向的教育訓練模組及OSCE評估對譫妄認知及處理之成效評估：叢聚隨機對照試驗

  Chen, K.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 開發高效能人工光合作用系統(2/2)

  Kuo, T.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 洗腎患者使用非類固醇抗發炎藥物與手術後併發症之相關性

  Lee, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 賽滅寧對於imiquimod誘發乾癬樣皮膚炎小鼠發炎反應及CD4+ T細胞平衡之影響

  Hou, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討膠質母細胞瘤外泌體中Btk/PD-L1/PD-L2 訊號途徑在腫瘤免疫所扮演的致病角色及其精準治療應用

  Lin, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 雙極症患者單核球和巨噬細胞活化與血管粥狀化的關聯性: 頸動脈超音波的個案對照研究(1/3)

  Tsai, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Beta 3腎上腺素信號傳導對心律異常的發生：從心室心肌細胞中心臟代謝，氧化壓力和鈣離子恆定的見解

  Hsieh, M.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 電子菸的心房電生理影響動物模式 – 對電子菸致心房心律失常潛在威脅的研究

  Lin, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 牙周致病菌加劇腹主動脈瘤生成的機制與開發標靶治療的可行性研究(1/3)

  Lin, F.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討非選擇性與選擇性組蛋白去乙醯酶抑制劑與免疫檢查點抑制劑合併治療之效用及其機轉(2/3)

  Huang, H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 研究新穎長鏈非編碼RNA LINAT在TGF-beta訊息動態及腫瘤惡化的角色(2/3)

  Chen, H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 透過非監督式微生物群基因體分類工具深度挖掘與分析微生物如何影響疾病的產生(1/3)

  Wu, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳房影像報告人工智慧醫療助理第二期發展計畫

  Tam, K.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology