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Effects of glutamine supplementation on T cell homeostasis and inflammatory response in inflammatory bowel disease
Yeh, S.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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臺蒙(MN)國合計畫-台灣及蒙古之洋蔥及蔥屬蔬菜對骨質疏鬆症的影響(1/3)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Exploring Biopathways Related to Cancer Based on Differences of Gene Expression between Cancer and Normal Situation
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Glucagon-Like Peptide-1 in the Regulation of PPARs and Calcium Handling in Hyperglycemia or Hypertensive HL-1 Cells
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Study of the Relationships among Anti-Obesity Activity, Adipogenesis, and Adipose Angiogenesis of Vegetable Indolic Derivatives---Involvement of the Ah Receptor/Arnt ? (II)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Immune Alteration and Immunogenic Cell Death in Advanced Non-Small Cell Lung Cancer Patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects and Mechanisms of Pitx2c Modulation for Atrial Electrophysiological and Structural Remodelings in Heart Failure
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Impact of Coping Skills Training on Stress, Symptom Distress in Children with Cancer
8/1/13 → 10/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Dietary Advanced Glycation Endproducts Are Associated with the Development of Polycystic Ovary Syndrome: The Mechanisms of Action
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Neurotrophic/Neuroprotective Role of GIP in Cellular and Rodent Models of Mild Traumatic Brain Injury (II)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Association Study of Genetic Polymorphisms of Toll-Like Receptors on Ischemic Stroke (I)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Degradation of nitrogen-containing PPCPs: kinetic study, application, and balancing the toxicity of N-DBP and intermediates through bioassay
Chang, E.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Development of Strontium-Impregnated Bioabsorbable Bone Screw for Fracture Fixation in Osteoporotic Bone
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effect of Improved Nutrition Care on the Progress of Hemodialysis Patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Trends in Surgical Litigation and Media Coverage of Medical Malpractice: Implications for Medical Education
Lyu, S.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effects of LED Light on Porphyromonas gingivalis in Periodontitis for Anti-Inflammation and Alveolar Bone Regeneration
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Hospital Patient Safety Culture-Comparison of Major Measurement Tools, Promotion Methods and Their Evaluation
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Analyses the Role of ADAM9-Hemidesmosome Components Interaction in Malignant Cancer Metastasis and Future Therapeutic Strategy
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Analysis and Data Mining of Decision Characteristic of Prehospital Emergency Patients Transport
Hsu, C.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The effect of vascular endothelial growth factor gene polymorphism in the pathogenesis and therapeutic response of pterygium
Cheng, Y.
8/1/13 → 12/31/14
Project: C - Project of Alliance › r - Tung's Taichung MetroHarbor Hospital
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The role of microRNA let-7g in cytosolic Ca2+ regulation and COX-2 gene expression
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Genomic and non-genomic estrogen effects on the spinal NR2B-related uterus-colon crosstalk in rats
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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To Predict the Recurrence of Major Depressive Disorder Within an Integrated Bio-Psycho-Social Framework---A Follow-up Study
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Sleep and Memory Consilidation in Alzheimer Disease
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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A Study on Trans-Neuronal Striato-Nigral Degeneration-Induced Movement Disorders after Stroke---Evaluation with Grey Matter Suppression IR and Diffusion Tensor Imaging (II)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Sumoylation of Histone Deacetylase 2 Contributes to CTGF Expression and Pulmonary Fibrosis in Chronic Obstructive Asthma (I)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Depression Trajectories in Women – A Developmental-ecological approach (GM03)
8/1/13 → 9/30/14
Project: A - Government Institution › b - Ministry of Science and Technology
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大腸直腸癌已躍居世界上癌症死亡率第二名,屬於固體型腫瘤,缺氧常見於此類 腫瘤,並誘發HIF-1α 表現而導致抗藥性及預後較差,因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑,可殺死癌 細胞而不影響正常細胞,對小鼠也不具毒性。我們初步結果顯示,Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現,代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性,對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下,經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制;也有研究報導指出,藥物會誘導癌細胞產生autophagy,造成細胞過度吞噬其內容 物而死亡,因此,autophagy在癌細胞為保護或是引發毒殺作用,目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活,但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示,除抑制HIF-1α 表現外,Zeb 也可活化AMPK、UPR/ER stress、以及autophagy, 因此我們推測Zeb 可在缺氧狀態下,促進autophagic cell death。3 年內我們將執行4 項 目標: (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。(第一年) (2) 研究Zeb 抑制HIF-1α表現之分子機轉。(第一年到第二年) (3) 研究Zeb 誘發autophagy之分子機轉。(第二年到第三年) (4) 探討Zeb 對缺氧導致抗藥性之作用。(第三年)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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抗氧化防禦基因標籤單核?酸多形性、氧化壓力生物標記與冠狀動脈心臟病之相關性(1/2)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Physical Properties and Biocompatibility of Orthodontic Elastomeric Chain after Nanoimprint Surface Treatment
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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榖胱甘月太硫轉移酉每參與乳癌致癌之分子機制探討(2/3)
Wu, C.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effect of Muscle Strength Training on Body Composition and Sarcopenic Obesity among the Female Overweight Elderly
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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An association study of arsenic exposure, inflammation, oxidative stress and the risk of developing cardiovascular diseases
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Novel activities of gamma-aminobutyric acid-mediated regulation of platelet activation, apoptosis, and autophagy: the non-genomic functions of NF-kappaB signal in anucleated cells
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Therapeutic Strategies for Traumatic Brain Injury with Novelly Desinged Drugs (II)
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The influence of Porphyromonas gingivalis GroEL in vascular cells
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Role of Androgen on Breast Cancer Development and Treatment
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Contribution of Er Stress to Inhibit miR-19a/b and miR-26b-Mediated CTGF Expression in Lung Fibrosis (I)
Chen, Y.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Anti-Tumor Mechanisms of a Novel Aliphatic Hydroxamate, WMJ-S-001---Targeting Tumor Angiogenesis and Lymphangiogenesis
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Trade, Economic Factors, Envrionmental Hazards, and Risks of Infant and Child Mortality in Developing Countries
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Functional Role of Growth Factor-Induced Metabolic Enzymes Expression in Cancer Cell Anti-Oxidation and Drug Resistance
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Study of Postoperative Adverse Outcomes of Surgical Patients Using Taiwan National Health Insurance Database
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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End-of-Life Care for Elderly with Advanced Dementia in Long-Term Care Facilities
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effects and Regulation of Oxidize Low Density Lipoprotein and High Density Lipoprotein on Human Endothelial Progenitor Cells
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Characterization of 5-Hydroxymethylcytosine and Ten-to-Eleven Translocation Gene (TET) in Cervical Cancer
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Exploring the effects of an exercise program on female diabetic patients$ health
Liao, Y.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects and Mechanisms of Massotherapy of Acupoints, Gene Polymorphisms of RRM1 and RRM2 on Relieving Chemotherapy-Induced Myelossupression among Patients with Cervical Cancer
8/1/13 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Exercise Training on Sleep Disturbances, Anxiety, and Depression among Newly Diagnosed Elderly Lung Cancer Patients
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Molecular mechanisms of alpha9-nicotinic acetylcholine receptor (alpha 9-nAChR)-mediated Trastuzumab (HerceptinR) drug resistance in breast cancer cells
Ho, Y.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Studies on the carcinogenic mechanisms of histamine N-methyltransferase-mediated breast cancer formation
Wu, C.
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology