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  Association Study of Rare Variants and Disease in Case-Parental Data with One of Parents Missing

  Chen, J.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • genome-wide association study 100%
  • alleles 59%
  • methodology 46%
  • gene frequency 40%
  • genes 29%

• Genomic and Non-Genomic Estrogen Effects on the Spinal Nr2b-Related Uterus-Colon Crosstalk in Rats

  Lin, T.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • uterus 100%
  • colon 95%
  • estrogens 62%
  • irritable bowel syndrome 33%
  • comorbidity 31%

• A Study on Trans-Neuronal Striato-Nigral Degeneration-Induced Movement Disorders after Stroke: Evaluation with Grey Matter Suppression Ir and Diffusion Tensor Imaging( I )

  Chen, C.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Movement Disorders 100%
  • Stroke 53%
  • Diffusion Tensor Imaging 50%
  • Middle Cerebral Artery 48%
  • Gray Matter 45%

• Roles of Central Orexin Activities in the Pathophysiology of Hypertension in Shr

  Hwang, L.

  8/1/12 → 9/30/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Orexins 100%
  • Orexin Receptors 97%
  • Inbred SHR Rats 57%
  • Hypertension 30%
  • Arterial Pressure 23%

• Detrimental Effects of an Aryl-Hydrocarbon Receptor Agonist, 3mc, on Brain Vascular Integrity and Permeability, and the Therapeutic Intervention by Statin Derivatives.

  Juan, S.

  8/1/12 → 9/30/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Aryl Hydrocarbon Receptors 100%
  • Retinoblastoma Protein 56%
  • extracellular matrix receptor 50%
  • Extracellular Matrix Proteins 49%
  • Phosphatidylinositol 3-Kinases 33%

• Analysis the Role of Satellite Cell during Denervation Induced Muscular Atrophy and a Trail of Transplantation of Adipocyte Derived Myogenic Stem Cells.

  Chang, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • atrophy 100%
  • myogenic regulatory factors 41%
  • stem cells 38%
  • muscular atrophy 37%
  • adipocytes 27%

• The Effects of Atherosclerosis Progression in Circulating Ferritin in Community-Based Population

  Bai, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • blood samples 100%
  • blood pressure 88%
  • cardiovascular disease 88%
  • chronic illness 69%
  • examination 40%

• Therapeutic Strategies for Traumatic Brain Injury with Novelly Desinged Drugs( I )

  Wang, J.

  8/1/12 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

  • Traumatic Brain Injury 100%
  • Research Personnel 51%
  • Pharmaceutical Preparations 22%
  • Touch 18%
  • MicroRNAs 15%

• Characterizationof Platelet-Rich Fibrin Releasing Growth Factors and Its Application on Regeneration of Nerve Injury during Radical Prostatectomy

  Ho, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • fibrin 100%
  • prostatic neoplasms 58%
  • nerve regeneration 51%
  • growth factors 40%
  • adhesives 38%

• Novel Activities of Gamma-Aminobutyric Acid-Mediated Regulation of Platelet Activation, Apoptosis, and Autophagy: the Non-Genomic Functions of Nf-Kappab Signal in Anucleated Cells

  Sheu, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • gamma-Aminobutyric Acid 100%
  • Blood Platelets 65%
  • Platelet Activation 27%
  • Mitochondrial DNA 26%
  • Autophagy 20%

• Therapeutic Strategies for Traumatic Brain Injury with Novelly Desinged Drugs( I )

  Wang, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Traumatic Brain Injury 100%
  • Research Personnel 51%
  • Pharmaceutical Preparations 22%
  • Touch 18%
  • MicroRNAs 15%

• A Study of Diffusion Tensor Imaging as a Potential Surrogate Marker for the Management of Acute Ischemic Cerebral Stroke: a Clinical and Animal Model at 7t

  Chen, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Anisotropy 100%
  • Diffusion Tensor Imaging 36%
  • Stroke 32%
  • Animal Models 28%
  • Magnetic Resonance Imaging 21%

• The Integrated Theraptic Effect of the Major Components of Psidium Guajava L. Aqueous Extracts (Pe) (Gallic Acid, Quercetin, Egcg, and Rutin) Combining with Medical Trials and Control Diets on the Chronic Kidney Disease

  Chen, K.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chronic Renal Insufficiency 100%
  • Gallic Acid 66%
  • Psidium 32%
  • Diet 27%
  • Rutin 26%

• Translational Genomic Approaches in Endometriosis

  Tzeng, C.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • endometrium 100%
  • microRNA 90%
  • stem cells 61%
  • cell adhesion molecules 54%
  • metastasis 35%

• The Roles of Fibronectin Fragments in the Articular Chondrocytes: from Single Nucleotide Polymorphism to Functional Investigation.

  Lee, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • fibronectins 100%
  • chondrocytes 59%
  • cartilage 53%
  • integrins 43%
  • osteoarthritis 23%

• The Neurotrophic/Neuroprotective Role of Gip in Cellular and Rodent Models of Mild Traumatic Brain Injury.( I )

  Lin, J. & Chen, R.

  8/1/12 → 7/31/13

  Project: B - Project of TMU › i - Other (Funded by TMU)

  • Peptides 62%
  • Glucose 62%
  • Incretins 25%
  • Glucagon-Like Peptide 1 23%
  • Neuroprotection 20%

• Studies of Cxcl12 in Hypoxia-Induced Pulmonary Fibrosis

  Chen, B. & Chung, C.

  8/1/12 → 7/31/13

  Project: B - Project of TMU › i - Other (Funded by TMU)

  • Hypoxia 100%
  • Pulmonary Fibrosis 65%
  • Fibroblasts 61%
  • Lung 57%
  • Phosphatidylinositol 3-Kinases 37%

• The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation

  Liang, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Pyroptosis 100%
  • Apoptosis 69%
  • Genes 65%
  • Inflammasomes 60%
  • Cell Proliferation 58%

• Application of Functional Electrical Stimulation on the Study of Nerve Regeneration in the Rat with Diabetic Neuropathy

  Peng, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Electric Stimulation 100%
  • Nerve Regeneration 94%
  • Urinary Tract 93%
  • Diabetes Mellitus 49%
  • Nerve Fibers 45%

• Involvement of Glycosphingolipids and Toll-Like Receptors in Response to Helicobacter Pylori Infection in Gastric Epithelial Cells

  Lin, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Helicobacter pylori 100%
  • Helicobacter Infections 61%
  • Stomach 41%
  • Ceramides 40%
  • Epithelial Cells 32%

• Translational Studies of Mycobacterium Tuberculosis-Induced Lung and Pleural Fibrosis

  Lin, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Connective Tissue Growth Factor 100%
  • Mycobacterium tuberculosis 57%
  • Fibroblasts 34%
  • Lung 31%
  • Pulmonary Fibrosis 28%

• Investigation of the Molecular Mechanisms of a Novel Finger Protein, Znf179, in Neuronal Differentiation

  Lee, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Cell Cycle Checkpoints 100%
  • Proteins 94%
  • Knockout Mice 94%
  • Cell Differentiation 83%
  • Cell Cycle Resting Phase 62%

• Characterization of Molecular and Pathological Role of Hs 1-Associated Protein X-1(Hax-1) in Cisplatin Induced Nephorotoxicity via Hax-1 Conditional Knock out Mice

  Lin, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Cisplatin 100%
  • Kidney 45%
  • Knockout Mice 31%
  • Renal Insufficiency 22%
  • Wounds and Injuries 16%

• 榖胱甘月太硫轉移酉每參與乳癌致癌之分子機制探討(1/3)

  Wu, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Role of the Endoplasmic Reticulum Stress Related Proteins, Glycoprotein 96(Gp96), in Liver Cancer Progression and Metastasis and the Clinically Therapeutic Implication

  Huang, M.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glycoproteins 100%
  • Heat-Shock Proteins 36%
  • Endoplasmic Reticulum Stress 26%
  • Liver Neoplasms 23%
  • Neoplasm Metastasis 21%

• Effects of Glutamine Supplementation on T Cell Homeostasis and Inflammatory Response in Inflammatory Bowel Disease

  Yeh, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • glutamine 100%
  • inflammatory bowel disease 84%
  • colitis 78%
  • T-lymphocytes 59%
  • ulcerative colitis 57%

• Development of Targeted Cancer Agents Using a Naturally Occurring Scaffold and Knowledge-Based Design

  Huang, W.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone 100%
  • Antitumor 25%
  • Antiproliferative 18%
  • Antineoplastic Agent 16%
  • Osthole 16%

• A Study of the Influence on Medical University Students$ Beliefs in Mathematics by Liberal Arts Courses in Mathematics Culture

  Ying, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • mathematics 100%
  • art 20%
  • triangulation 20%
  • history 14%
  • university 12%

• Design and Evaluation of a Novel Drug-Containing Ceramic Hydrogel for the Healing of Alveolar Bone Defect

  Lee, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • osteoblasts 100%
  • bones 96%
  • healing 49%
  • attachment 42%
  • stem cells 39%

• Study on the Cancer and Non-Cancer, Including Cardovascular Diseases, Risks in Cohort Population with Prolonged Low-Dose Radiation Exposure

  Chang, W.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Taiwan 100%
  • Radiation Exposure 79%
  • Population 59%
  • Cohort Studies 51%
  • Mortality 50%

• The First Randomized Controlled Clinical Trial for Computerized Decision Support System (II)

  Li, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Contrast Media 100%
  • Drug-Related Side Effects and Adverse Reactions 60%
  • Clinical Decision Support Systems 56%
  • Physicians 54%
  • Randomized Controlled Trials 43%

• The Role of Cytoplasmic APe1 in Tumor Malignancy, Drug Resistance and Lung Cancer Prognosis

  Lee, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • NF-kappa B 100%
  • Oxidation-Reduction 45%
  • Cell Nucleus Active Transport 44%
  • Lung Neoplasms 37%
  • Neoplasms 36%

• The Role of Cd69 in Tnfalpha-Inhibited Erythroid Differentiation

  Huang, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Erythropoietin 100%
  • Anemia 35%
  • Hematopoietic Stem Cells 31%
  • Inflammation 31%
  • alpha-Globins 29%

• 探究腦指蛋白 ZNF179 (Brain Finger Protein) 的分子機制

  Huang, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Roles of Micrornas in Endothelin-1 and Hypoxia-Induced Ctgf Production

  Chen, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • Endothelin-1 59%
  • Hypoxia 31%
  • Fibrosis 29%
  • Lung 23%

• The Relationship between Sleep and Memory in Alzheimer Animal

  Hu, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Alzheimer Disease 100%
  • Memory Consolidation 93%
  • REM Sleep 91%
  • Sleep 85%
  • Dementia 30%

• Therapeutic Evaluation Etanercept, a Tumor Necrosis Factor Antagonist, in Experimental Heatstroke

  Chang, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • heat stroke 100%
  • tumor necrosis factors 42%
  • therapeutics 32%
  • death 31%
  • animal models 18%

• The Studies on the Mechanism of Intravenous Immunoglobulin (Ivig)-Induced Inhibitory Functions on Neutrophil Recruitments

  Chang, J.

  8/1/12 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Intravenous Immunoglobulins 100%
  • Leukocyte Rolling 38%
  • Leukocytes 25%
  • Neutrophil Infiltration 23%
  • E-Selectin 12%

• 睡眠困擾是癌症病人最常主訴的問題之一。患有睡眠困擾之癌症病人經常同時伴隨 疲憊、憂鬱等現象發生，形成症狀群集，影響生活品質。雖然目前對於癌症病人睡眠障 礙之量性研究已多有著墨，然而對於癌症病人經歷睡眠障礙之主觀經驗之瞭解，仍相當 有限。瞭解病人經歷睡眠障礙之主觀經驗，將有助於未來睡眠評估工具之修訂。另外， 在評估癌症病人睡眠品質時，若能以簡單工具評估，會更具效率及助益。阿森斯失眠量 表(Athens Insomnia Scale, AIS) 是一個簡單的8 題問卷，廣為使用在一般失眠的病人， 在癌症病人使用上，尚未有豐富的實證資料，若能建立其在癌症病人的信效度，將可作 為一簡單篩檢癌症病人失眠的工具。 睡眠遵行日夜節律規則，日夜節律又需要光作為矯正的線索，光在癌症病人睡眠的 角色，尚未有研究證實，過去研究顯示癌症病人睡眠品質不佳與生物節律有關係。光是 重要日夜節律的線索，光療法透過褪黑激素調節，調整日夜節律週期，可能可以改善睡 眠品質。另外，由於，睡眠障礙、憂鬱、疲憊經常形成一症狀群集，光療法於改善睡眠 障礙之同時，是否亦同時改善憂鬱、疲憊及生活品質。目前，光療法在癌症病人的運用 上，付之闕如，故建立光療法於癌症病人的有效性值得探究。 本研究為三年期研究計畫，目的包括有：1.瞭解癌症個案對於睡眠困擾的主觀經驗 （第一年）。2.建立阿森斯失眠量表中文版的信效度、敏感性、特異性（第一年）。3.瞭 解癌症病人光暴露與生物節率、睡眠障礙的關係（第二年）。4.瞭解光療法對於改善癌 症病人睡眠障礙及相關症狀群集、及生活品質之成效；以及瞭解光療法影響褪黑激素之 程度（第三年）。 本研究擬以癌症住院及門診病人為對象，研究工具包括基本資料、匹茲堡睡眠品質 問卷、阿森斯失眠問卷，簡明疲憊量表，貝克憂鬱量表度、SF-36 生活品質量表、腕動 力器等。資料處理分析方式包括：內容分析、描述性統計、t 檢定、皮爾森相關、GEE (generalized estimating equations)等。 本研究之結果將可瞭解光暴露與生物節率與睡眠障礙之間的關係，並可進一步瞭解 光療法作為改善癌症病人睡眠障礙之護理措施之成效，以期，最終能藉由改善癌症病人 之睡眠品質提昇病人之生活品質。

  Lin, C.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sleep 100%
  • Phototherapy 34%
  • Neoplasms 25%
  • Sleep Initiation and Maintenance Disorders 22%
  • Light 15%

• Bullying Experience, Attitude and Suicide Attempts among Adolescents

  Chen, P.

  8/1/12 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Bullying 100%
  • Suicide 41%
  • Taiwan 7%
  • Psychometrics 7%
  • Mental Health 5%

• Effects of Maternal Depressive Symptomatology on Pregnancy Outcomes and Newborn Development---How Is Paternal Psychopathology Involved?

  Chen, Y.

  8/1/12 → 9/30/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mothers 100%
  • Psychopathology 77%
  • Newborn Infant 75%
  • Spouses 59%
  • Pregnancy Outcome 59%

• Mechanisms of Apelin in Electrophysiological Characteristics and Calcium Dynamics in Left Atrium and Pulmonary Vein Cardiomyocytes Underlying the Pathophysiology of Atrial Fibrillation

  Chen, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Apelin 100%
  • Pulmonary Veins 51%
  • Cardiac Myocytes 39%
  • Atrial Fibrillation 27%
  • Calcium 13%

• Exploring the Effects of an Exercise Program on Female Diabetic Patients' Health

  Liao, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Lower Urinary Tract Symptoms 100%
  • Urinary Bladder 38%
  • Urinary Tract 19%
  • Exercise 12%
  • Quality of Life 12%

• The Pre-Clinical Assessment of the Anti-Tumor Efficacy of a Protein Vaccine and Mesenchymal Stem Cell Combined Therapy, Using Non-Invasive Molecular Imaging Technology

  Wu, T. A.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Vaccines 100%
  • Molecular Imaging 78%
  • Neoplasms 75%
  • Suicide 61%
  • Mesenchymal Stem Cells 59%

• Functional Role of Transcription Factor Sp1 in Brain Neuronal Injury( I )

  Chang, W.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Brain Injuries 100%
  • sigma Receptors 51%
  • Internal Ribosome Entry Sites 24%
  • Genes 20%
  • Animal Models 18%

• Molecular Therpary and Mechanism Study in Spinal Cord Injury

  Hung, K.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • 3-(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide 100%
  • 3-(1-benzenesulfonyl-1H-indol-5-yl)-N-hydroxyacrylamide 97%
  • Spinal Cord Injuries 31%
  • Chromatin 25%
  • Histone Deacetylase Inhibitors 16%

• Preceptors’ Perceptions of Training Programs and Training Needs, Experienced Barriers during Precepting, and Development and Effectiveness Evaluation of a Preceptor Intervention

  Chang, W.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • training program 100%
  • patient care 87%
  • nurse 64%
  • questionnaire 63%
  • interview 53%

• Molecular and Cellular Mechanism of Adipocyte Modulatory Effects on Pulmonary Vein and Atrium

  Chen, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Adipocytes 100%
  • Atrial Fibrillation 64%
  • Cardiac Myocytes 60%
  • Calcium 44%
  • Adipokines 37%

• Oral Health and Interventions for Elderly in Long-Term Care Facilities

  Chang, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • training program 100%
  • caregiver 64%
  • quality good 59%
  • lack 51%
  • health 45%

• Integrative Studies on Falls, Osteoporosis, and Fractures in Older People

  Lin, M.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • osteoporosis 100%
  • humeral fractures 29%
  • hip fractures 19%
  • quality of life 17%
  • risk assessment 15%