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  Explore of Toll-Like Receptors Associated Mirna Expression in Ischemic Stroke Patients (I)

  Wu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Anti-RRM-2 Antibody Drug Generation and Their Inhibitory Mechanisms

  Yang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Antibodies 100%
  • Single-Chain Antibodies 93%
  • Anti-Idiotypic Antibodies 60%
  • Diphosphates 47%
  • human RRM2B protein 46%

• Investigating the Differential Effects and the Mechanisms of Flavonols on Osteogenic Differentiation of Human Dental Pulp Stem Cells

  Lee, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • flavonols 100%
  • stem cells 78%
  • bone formation 73%
  • tooth pulp 70%
  • bones 26%

• Antibody-Mediated Immune Suppression of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)

  Burnouf, T. P. R.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Novel Porcine Bone Xenograft Development

  Chang, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • bones 100%
  • dentistry 66%
  • testing 36%
  • skeletal development 31%
  • biocompatibility 27%

• The role and molecular mechanism of PPARα in acute kidney injury: focus on the protective effect in renal tubular cell

  Hsu, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • MicroRNAs 100%
  • Type C Phospholipases 73%
  • Kidney 56%
  • Acute Kidney Injury 37%
  • Gentamicins 27%

• TMU101-AE1-B64

  Fang, S.

  8/1/13 → 7/31/16

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• Effects of fish oil on alcoholic liver disease in rats based on pathological mechanisms

  Yang, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • liver diseases 100%
  • alcohol abuse 83%
  • fish oils 81%
  • liver function 46%
  • rats 39%

• Evaluations of Anti-Photoaging, Anti-Melanogenesis and Transdermal Delivery of Safflower Yellow

  Chien, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Cosmetic 100%
  • Skin Protective 95%
  • Anti Melanogenesis 90%
  • Food Colouring 83%
  • Depigmenting Agent 82%

• Translational studies of Mycobacterium tuberculosis-induced lung and pleural fibrosis

  Lin, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Connective Tissue Growth Factor 100%
  • Mycobacterium tuberculosis 57%
  • Fibroblasts 34%
  • Lung 31%
  • Pulmonary Fibrosis 28%

• he Effects of the APOE4 Allele on cerebral Structural and Functional Connectivity- A Diffusion Tensor Imaging and Resting-state MRI study

  Chen, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Alleles 100%
  • Apolipoproteins E 93%
  • Brain 47%
  • Short-Term Memory 37%
  • Magnetic Resonance Imaging 31%

• Renoprotective mechanisms of soy protein in rats with diabetic nephropathy 全文電子檔： 全文連結1

  Chen, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • diabetic nephropathy 100%
  • soy protein 62%
  • blood glucose 29%
  • blood pressure 28%
  • proteinuria 20%

• A study of diffusion tensor imaging as a potential surrogate marker for the management of acute ischemic cerebral stroke: A clinical and animal model at 7T

  Chen, C.

  8/1/13 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Anisotropy 100%
  • Diffusion Tensor Imaging 36%
  • Stroke 32%
  • Animal Models 28%
  • Magnetic Resonance Imaging 21%

• 設計並評估新型含藥人工骨凝膠對齒槽骨缺損的修復作用

  Lee, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • osteoblasts 100%
  • bones 83%
  • attachment 42%
  • stem cells 39%
  • healing 32%

• Use the organometal catalytic reaction to synthesize the heterocycle-based anticancer agents

  Liou, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Antineoplastic Agent 100%
  • Hydroxyl 93%
  • Antiproliferative 56%
  • Antitumor 52%
  • Structure-Activity Relationship 48%

• Preparation and Application of New Type Matrix for Aligned Cell Sheet Engineering Use

  Tseng, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Tissue 100%
  • Cell culture 65%
  • Membranes 56%
  • Engineering technology 40%
  • Cystines 33%

• The Anti-Tumor Mechanisms of a Novel Aliphatic Hydroxamate, WMJ-S-001---Targeting Tumor Angiogenesis and Lymphangiogenesis

  Hsu, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • WMJ-S-001 100%
  • Lymphangiogenesis 25%
  • Neoplasms 15%
  • Endothelial Cells 14%
  • Vascular Endothelial Growth Factor A 9%

• Smart Microtube Array Membrane Scaffold for Nerve Regeneration---Fabrication, in vitro and in vivo Evaluation

  Chen, C.

  8/1/13 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • nerves 100%
  • regeneration 49%
  • porous walls 43%
  • stem cells 40%
  • cells 31%

• 抽菸、α9-型尼古丁乙醯膽鹼受體、表皮生長因子受體及動情激素相關基因與乳癌之分子流行病學研究

  Chiou, H.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Huntingtin-Associated Protein-Regulated Biomarkers in Neurodegenerative Diseases

  Lin, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Proteins 100%
  • Proto-Oncogene Proteins c-bcr 55%
  • Neurodegenerative Diseases 47%
  • Microtubules 39%
  • Calcium 37%

• The Emerging Role That Splicing Factor Plays in the Adipose Development

  Lin, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • brown adipose tissue 100%
  • adipose tissue 84%
  • insulin receptors 78%
  • adipogenesis 75%
  • energy 49%

• Motor Vehicle Injuries and Screening Tools of Unsafe Driving in Older Drivers

  Lin, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Screening 100%
  • Emergency rooms 57%
  • Motorcycles 43%
  • Public health 42%
  • Medical problems 39%

• Investigation of the transcriptional and epigenetic mechanisms for the Nm23-H1 expression: An nm23-H1-promoter screening platform for novel metastasis-suppressing anticancer drugs

  Wang, L.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Neoplasm Metastasis 100%
  • Genetic Promoter Regions 93%
  • Methylation 87%
  • Esophageal Neoplasms 66%
  • Tumor Suppressor Genes 63%

• The role of DDX3 in human papillomavirus-infected lung tumorigenesis

  Lee, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Papillomavirus Infections 100%
  • Cisplatin 96%
  • Lung 86%
  • Neoplasms 63%
  • Gastropoda 47%

• The Association Study of Genetic Polymorphisms of Toll-Like Receptors on Ischemic Stroke (I)

  Chiou, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies of Anti-Cancer Activity of Folic Acid

  Lee, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Association of Epidermal Growth Factor Receptor mutations with HPV16/18 E6 Oncoprotein Expression in Non-Small Cell Lung Cancer

  Lee, H.

  8/1/13 → 7/31/14

  Project: C - Project of Alliance › r - Tung's Taichung MetroHarbor Hospital

• Dissected the role of Glucosed-regulated portein 78 in the progression, metastasis and therapy of colorectal cancer

  Wei, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • colorectal neoplasms 100%
  • metastasis 69%
  • neoplasms 55%
  • endoplasmic reticulum 32%
  • death 27%

• Design and Development of Antibody-Targetable and Self-Assembled Micelles of Anticancer Drug Conjugate and Complex of Hyaluronic Acid

  Sheu, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Micelle 100%
  • Hyaluronic Acid 73%
  • Doxorubicin 53%
  • Drug 40%
  • Complexation 29%

• The Determinant Clinical Parameters for Shifting Prescriptions among Nifedipine+Quercetin; Atorvastatin, and Captopril+Quercetin in Treating the Hypertension of Chronic Kidney Disease

  Chen, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Quercetin 100%
  • Doxorubicin 88%
  • Chronic Renal Insufficiency 52%
  • Antihypertensive Agents 35%
  • Atorvastatin 23%

• The effect of vascular endothelial growth factor gene polymorphism in the pathogenesis and therapeutic response of pterygium

  Cheng, Y.

  8/1/13 → 12/31/14

  Project: C - Project of Alliance › r - Tung's Taichung MetroHarbor Hospital

• 利用三段式螢光共振能量轉移觀察基因藥物與聚合微膠體在不同角膜分佈穿透(2/3)

  Liaw, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • pyrimidin-2-one beta-ribofuranoside 100%
  • Autophagy 29%
  • Hypoxia 17%
  • Autophagic Cell Death 16%
  • Unfolded Protein Response 13%

• The Effects of LED Light on Porphyromonas gingivalis in Periodontitis for Anti-Inflammation and Alveolar Bone Regeneration

  Deng, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Porphyromonas gingivalis 100%
  • Light 81%
  • Bone Regeneration 64%
  • Inflammation 47%
  • Alveolar Bone Loss 46%

• The Application of Fluoxetine and Its Related Medicines in Brain Tumor Treatment

  Shen, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Brain Neoplasms 100%
  • AMPA Receptors 47%
  • paroxetine receptor 47%
  • Glioblastoma 39%
  • Sertraline 26%

• Study the Klf10 alters metabolic pathways in genetic-deficient mice and human pancreatic ductal carcinomas

  Chang, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • 1-(7-(2-hydroxyethyl)dodecahydro-3a-methyl-1H-benz(e)inden-3-yl)ethanone 100%
  • Metabolic Networks and Pathways 49%
  • Pancreatic Neoplasms 46%
  • Knockout Mice 45%
  • Insulin Resistance 40%

• Cellular and Molecular Mechanisms of Nicotine and Nitrosamines Promote Tumorigenic Behaviors in Renal Cell Carcinoma (Ii)

  Cheng, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Synaptic Plasticity by Nogo-1 Receptor Overexpression and Exendin-4 Administration on Behavioral and Electrophysiological Recovery after Mild Traumatic Brain Injury (II)

  Tsai, S.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Study on the Preventive Effect and Mechanism of Germinated Brown Rice and Its Components on Colorectal Cancer

  Shih, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • brown rice 100%
  • colorectal neoplasms 49%
  • carcinogenesis 43%
  • health promotion 34%
  • rice 26%

• Effects of indoor air quality improvement on cardiovascular health in general population

  Chuang, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Indoor Air Pollution 100%
  • Air Pollution 15%
  • Taiwan 13%
  • Cardiovascular System 13%
  • Quality Improvement 13%

• Genetic polymorphisms of calcium channel in the risk of breast cancer

  Chang, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Calcium Channels 63%
  • Breast Neoplasms 60%
  • Genetic Polymorphisms 37%
  • Calcium 24%
  • Case-Control Studies 18%

• Investigation of the Functions of Brain Finger Protein, Znf179, in Embryo Development and in Adult Brain

  Lee, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Blood Vessels 100%
  • Embryonic Structures 92%
  • Knockout Mice 77%
  • Spatial Learning 68%
  • BFP ring finger protein 64%

• Explore of Toll-Like Receptors Associated Mirna Expression in Ischemic Stroke Patients (I)

  Wu, C.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Synaptic Plasticity by Nogo-1 Receptor Overexpression and Exendin-4 Administration on Behavioral and Electrophysiological Recovery after Mild Traumatic Brain Injury (II)

  Tsai, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Postoperative Adverse Outcomes of Surgical Patients Using Taiwan National Health Insurance Database

  Chen, T.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Design and Characterization of Multifunctional Self-Assembling Lecithin/Amphiphilic Polymers Mixed Micellar Delivery Systems

  Sheu, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Novel Degradable Biomaterial for Dental Hemostatic Sponge Applications

  Lin, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • teeth 100%
  • surgery 91%
  • hemostasis 60%
  • biocompatibility 52%
  • animal experimentation 52%

• The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation

  Liang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Pyroptosis 100%
  • Apoptosis 69%
  • Genes 65%
  • Inflammasomes 60%
  • Cell Proliferation 58%

• Study the Therapeutic Effects and Novel Molecular Mechanisms of Resveratrol in Human Osteosarcoma: the Treatment of Metastatic Cancer

  Chien, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of ADAM 17 in Hypoxia-Induced CTGF Expression and Pulmonary Fibrosis (I)

  Chen, B.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology