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• 乳癌細胞α9尼古丁受體作為新穎靶向RNA奈米藥物與T細胞療法之臨床轉譯研究-探討α9尼古丁受體基因表現在乳癌病人血液循環腫瘤細胞/游離DNA於乳癌治療的應用(2/3)

  Tzeng, H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展一新型藥物作為改善肥胖及肥胖引發糖尿病導致腎病變症候群之轉譯醫學研究(3/3)

  Lin, H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抑制PCSK9對於改善心房纖維化之機轉以及治療心房纖維化引發心律不整治療之創新應用研究。(3/3)

  Chung, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 辛伐他汀抗腎細胞癌的作用，經由抑制代謝重編程從mTOR、PPAR到RhoA(3/3)

  Juan, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以新式片狀細胞工學製備自體片狀心肌細胞及其應用在缺血性心臟病的動物模式-後期

  Tseng, H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展三功能抗體(EGFR/CD3/mPEG)修飾之聚乙二醇-免疫增敏奈米藥物以主動標靶毒殺大腸癌並同時強化體內T細胞於腫瘤微環境抗癌功效之創新協同療法-開發三功能抗體(EGFR/CD3/mPEG)以協同加成聚乙二醇-免疫增敏奈米藥物及T細胞於大腸癌腫瘤微環境之抗癌功效(2/3)

  Lin, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 晝夜節律對大腦液體屏障之調節

  Myung, J.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Etelcalcetide經由調控DUSP4和TRAF3路徑於慢性腎臟疾病-礦物質骨病變可改善硫酸??酚引起的低骨轉換率(1/3)

  Zheng, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 甲基乙二醛經ChREBP/SREBP1造成腎小管脂毒性進而調控PGC1/SIRT3導致電子傳遞鏈缺陷之糖尿腎病進展-探討水飛薊素(Silybin)合併Metformin之逆轉潛能

  Chen, K.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 副甲狀腺素藉由SFRP2導致動靜脈廔管病變之惡化 – 預防動靜脈廔管不成熟之新治療標的 (第二年延續計畫)

  Liu, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討急性肺損傷之精準幹細胞治療策略與臨床應用: 肺部微環境修復之分子與細胞圖譜及其作用機制-臨床級胎盤間葉幹細胞對急性肺損傷/急性呼吸窘迫症之免疫調控與肺組織再生之治療機制(1/3)

  Huang, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 開發1,3-二芳基取代之五元雜環作為抗胰臟癌劑(3/3)

  Lee, H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 金屬蛋白?組織抑制劑3之基因多形性與血漿濃度、總尿液砷濃度、紅血球鉛與鎘濃度和血漿硒濃度與慢性腎臟病的相關性

  Hsueh, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 魚類感覺系統在酸性環境下的功能變化-從側線到行為的探討(1/3)

  Horng, J.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 組織胺甲基化轉換酵素(HNMT)輔助臨床醫師鑑別乳癌病患作為Herceptin療效評估之新穎分子標記(3/3)

  Ho, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 天然物對鉑類抗藥性膀胱癌之治療潛力及其分子作用機轉探討(3/3)

  Chen, M.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建構定量系統生理基礎藥動模型以評估腸道菌叢對口服藥物代謝影響及協助奈米膠體處方之開發(2/3)

  Hsieh, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以快速動眼期睡眠剝奪大鼠模型研究鋰鹽心臟保護作用、生理恆定負荷調節、及粒線體生物能量調控之分子機轉

  Chen, P.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討膠質母細胞瘤外泌體中Btk/PD-L1/PD-L2 訊號途徑在腫瘤免疫所扮演的致病角色及其精準治療應用

  Lin, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以尿?雙磷酸葡萄糖醛酸基轉移?2B7 (UGT2B7) 開發新穎三陰性乳癌標靶治療策略(2/3)

  Lee, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 在國際健康功能與身心障礙分類系統的架構下，探討蛋白質補充合併運動訓練對急慢性機構衰弱老人改善肌少症指數及身體活動功能之成效(3/3)

  Liou, T.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討引導受體與配體之間的cis-弱化互動對脊髓運動神經迴路形成的影響(1/3)

  Kao, T.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立智慧神經加護病房資料庫（MiNiC）(3/3)

  Lin, M.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立國人電腦斷層脊椎椎體結構強度之預測模型

  Chen, H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 打造即時「同理心溫度計」協助醫病互動(1/2)

  Li, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 針對PD-L1表現機制所發展出之口腔癌治療策略(3/3)

  Lin, H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以資料探勘技術進行大數據分析，建立術中低血氧與術後休克風險預測模型(2/2)

  Lin, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 玻尿酸包埋kaempferol的奈米粒子治療膝關節骨性關節炎的研究

  Lee, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 進展性胰臟癌新穎增進免疫療法的治療策略與生物指標-對免疫療法併用方案節拍式化療或射頻燒灼療法之胰臟癌患者進行基因標記和免疫基因組庫之鑑定與分析(3/3)

  Chang, W.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 開發天然物及其衍生物應用於阿茲海默症之治療(1/3)

  Pan, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• ASPM-PAR-PCP訊息軸於侵犯性癌幹細胞造成癌轉移的角色與其標靶治療(3/3)

  Tsai, K. K.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 在慢性阻塞性氣喘中double cortin like kinase 1 (DCLK1)在thrombin誘導IL-8/CXCL8表現及氣道發炎的病理角色之研究(2/3)

  Chen, B.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討KH-Type切割調控蛋白在腎細胞癌惡性進程中所扮演的角色(2/3)

  Chien, M.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• A multi-modal investigation of the neurobiology of psychomotor alterations in mania and depression (2/2)

  Martino, M.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討新型冠狀病毒棘狀蛋白S1誘導心臟電生理及結構性重塑之病理機制：治療新型冠狀肺炎引發心臟損傷之新契機

  Kao, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Using Deep Learning to Improve Cerebrovascular Reserve Measurement from Baseline Mri

  Chen, D. C. & Li, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 長期高脂飲食誘發之腸道菌相改變、食物與脂肪代謝產物、與肝臟及腦部功能退化之相關性

  Lin, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以靜磁場抑制新冠肺炎病毒與宿主的膜融合作用並降低其感染引發的過度免疫反應之研

  Huang, H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討海馬迴神經與膠質細胞交互作用於腦創傷後長期認知後遺症之機制作為藥物治療之契機

  Wang, J.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討去磷酸?PP4在柴油排放粒子誘導嚴重過敏性發炎反應中的角色(1/3)

  Yang, F.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 製作三維列印生物墨水加載幹細胞應用於骨再生之研究(1/3)

  Chang, W.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以深度學習來預測細胞表面蛋白並應用單細胞轉錄體之功能分類鑑別

  Chen, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 從食品風險暴露之角度探討非營養性甜味劑對女性生殖狀況之影響-非營養性甜味劑對子宮收縮及生殖細胞之影響效應及相關機轉探討(2/3)

  Hsia, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 單側唇腭裂患者的鼻道阻塞的評估與治療2(2/2)

  Chen, K.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討EZH2在嚴重氣喘中媒介纖維化蛋白表現及呼吸道纖維化之機轉(2/3)

  Lin, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 藉由活化JNK路徑以治療Osimertinib抗藥性肺腺癌的策略研究

  Yao, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討CDK4/6抑制劑在兒童惡性腦瘤治療的可行性(第二年)(3/3)

  Hsieh, T.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 磷酸化Dicer蛋白調節微核糖核酸生合成及麩醯胺酸代謝轉變在胰臟癌吉西他濱抗藥性的作用

  Chiu, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 吳茱萸生物鹼rutaecarpine調控血小板活化及自噬作用的機轉探討以及在自體血栓塊引起腦中風鼠的活性評估: NF-kB在無核細胞中的角色(3/3)

  Sheu, J.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 台灣藜殼應用於肥胖相關代謝異常鐵過量症狀及發炎性貧血之輔助治療: 腸-肝-脂肪-骨髓軸線與鐵調素-轉鐵膜蛋白機制對血鐵代謝之影響

  Chang, J.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology