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• Cytotoxicity and Application on Drug Resistant Cells of Halide Derivatives of Rutaecarpine

  Lin, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Genomic and Non-Genomic Estrogen Effects on the Spinal Nr2b-Related Uterus-Colon Crosstalk in Rats

  Lin, T.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Translational Genomic Approaches in Endometriosis

  Tzeng, C.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Combine Anesthesia Information System with Artificial Neural Networks to Develop the Surgical Complication Pre-Warning System

  Lin, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討鎮靜藥物dexmedetomidine保護腦血管免於缺血-再灌流傷害之機轉: 細胞和動物研究

  Wu, G.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Modulation of Tumor Microenvironment by Nucleic Acid Chimeras as a New Paradigm for Adjuvant Cancer Therapy

  Yeh, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploring the Regulatory Mechanisms of Ep2-Mediated Epithelial-Mesenchymal Transition in Esophageal Squamous Cell Carcinoma

  Kuo, K.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies the Function and Mechanism of Dnaja3a/Dnaja3b and Interaction Molecules during the Embryonic Satges

  Chow, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of Pacemaker Current Inhibitor (Ivabradine) on Sinoatrial Node Function and Pulmonary Vein Arrhythmogenesis

  Lin, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development a Tissue-Like Block by Novel Porous Calcium Phosphate Combined Dental Pulp Stem Cells and Platelets Rich Fibrin for Bone Regeneration in Large Bony Defect

  Lee, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies of Cxcl12 in Hypoxia-Induced Pulmonary Fibrosis

  Chen, B.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of the Relationships among Anti-Obesity Activity, Adipogenesis, and Adipose Angiogenesis of Vegetable Indolic Derivatives – Involvement of the Ah Receptor/Arnt ?

  Chen, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Indoor Air Quality Improvement on Cardiovascular Health in General Population

  Chuang, K.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Motorcyclist Behavioural Patterns to Pedestrian Green Signal Countdown Device (Pgscd): a Mixed Logit Analysis

  Pai, C.

  8/1/12 → 9/30/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mechanisms of Apelin in Electrophysiological Characteristics and Calcium Dynamics in Left Atrium and Pulmonary Vein Cardiomyocytes Underlying the Pathophysiology of Atrial Fibrillation

  Chen, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Glutamine Supplementation on T Cell Homeostasis and Inflammatory Response in Inflammatory Bowel Disease

  Yeh, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the Immuno-Modulatory Effects of Notch Ligand Delta 4 on Immune Cells and in Ova-Induced Asthmatic Mice

  Lee, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Diffusion Tensor Imaging to Study the White Matter Integrity and Coherence in Resting Electroencephalography

  Shiu, R.

  8/1/12 → 1/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Essential Oils on Smooth Muscle Contraction in Rat Uterus (Gm07)

  Hsia, S.

  8/1/12 → 12/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular and Cellular Mechanism of Adipocyte Modulatory Effects on Pulmonary Vein and Atrium

  Chen, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 榖胱甘月太硫轉移酉每參與乳癌致癌之分子機制探討(1/3)

  Wu, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Neurotrophic/Neuroprotective Role of Gip in Cellular and Rodent Models of Mild Traumatic Brain Injury.( I )

  Lin, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Characterizationof Platelet-Rich Fibrin Releasing Growth Factors and Its Application on Regeneration of Nerve Injury during Radical Prostatectomy

  Ho, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Childhood Sleep Deprivation on the Development of Emotional Control and Cognitive Function of Prefrontal Cortex

  Chang, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Avoidable Hospitalizations and Primary Care Manpower in a Universal Health Insurance System: a 15-Year Trend Analysis

  Huang, K.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Adaptation of Multi-Source Appraisal of Medical Professionalism among Medical Students and Their Socialization Process.

  Chiu, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular Therpary and Mechanism Study in Spinal Cord Injury

  Hung, K.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Endothelin-1 Mediates Fibrocyte Differentiation in Chronic Obstructive Asthma

  Lin, C.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Endothelin-1 Mediates Fibrocyte Differentiation in Chronic Obstructive Asthma

  Lin, C.

  8/1/12 → 7/31/13

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Circuits of Igf-1r and Niche Signaling (Hypoxia/Inflammation) in Stem Cell Transformation and Its Clinical Implication of Molecular Target Therapy (Model of Germline Stem Cells)

  Huang, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 包載9α-型尼古丁乙醯膽鹼受體抑制劑之標靶性微脂體劑型設計與開發

  Sheu, M.

  8/1/12 → 7/31/13

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Design and Development of Antibody-Targetable and Self-Assembled Micelles of Anticancer Drug Conjugate and Complex of Hyaluronic Acid

  Sheu, M.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• NF-kB以及NF-kB repressing factor (NRF) 在慢性阻塞性肺疾病引發系統性發炎之角色探討(3/3)

  Lee, K.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 睡眠困擾是癌症病人最常主訴的問題之一。患有睡眠困擾之癌症病人經常同時伴隨 疲憊、憂鬱等現象發生，形成症狀群集，影響生活品質。雖然目前對於癌症病人睡眠障 礙之量性研究已多有著墨，然而對於癌症病人經歷睡眠障礙之主觀經驗之瞭解，仍相當 有限。瞭解病人經歷睡眠障礙之主觀經驗，將有助於未來睡眠評估工具之修訂。另外， 在評估癌症病人睡眠品質時，若能以簡單工具評估，會更具效率及助益。阿森斯失眠量 表(Athens Insomnia Scale, AIS) 是一個簡單的8 題問卷，廣為使用在一般失眠的病人， 在癌症病人使用上，尚未有豐富的實證資料，若能建立其在癌症病人的信效度，將可作 為一簡單篩檢癌症病人失眠的工具。 睡眠遵行日夜節律規則，日夜節律又需要光作為矯正的線索，光在癌症病人睡眠的 角色，尚未有研究證實，過去研究顯示癌症病人睡眠品質不佳與生物節律有關係。光是 重要日夜節律的線索，光療法透過褪黑激素調節，調整日夜節律週期，可能可以改善睡 眠品質。另外，由於，睡眠障礙、憂鬱、疲憊經常形成一症狀群集，光療法於改善睡眠 障礙之同時，是否亦同時改善憂鬱、疲憊及生活品質。目前，光療法在癌症病人的運用 上，付之闕如，故建立光療法於癌症病人的有效性值得探究。 本研究為三年期研究計畫，目的包括有：1.瞭解癌症個案對於睡眠困擾的主觀經驗 （第一年）。2.建立阿森斯失眠量表中文版的信效度、敏感性、特異性（第一年）。3.瞭 解癌症病人光暴露與生物節率、睡眠障礙的關係（第二年）。4.瞭解光療法對於改善癌 症病人睡眠障礙及相關症狀群集、及生活品質之成效；以及瞭解光療法影響褪黑激素之 程度（第三年）。 本研究擬以癌症住院及門診病人為對象，研究工具包括基本資料、匹茲堡睡眠品質 問卷、阿森斯失眠問卷，簡明疲憊量表，貝克憂鬱量表度、SF-36 生活品質量表、腕動 力器等。資料處理分析方式包括：內容分析、描述性統計、t 檢定、皮爾森相關、GEE (generalized estimating equations)等。 本研究之結果將可瞭解光暴露與生物節率與睡眠障礙之間的關係，並可進一步瞭解 光療法作為改善癌症病人睡眠障礙之護理措施之成效，以期，最終能藉由改善癌症病人 之睡眠品質提昇病人之生活品質。

  Lin, C.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Exercise Training on Sleep Disturbances, Anxiety, and Depression among Newly Diagnosed Elderly Lung Cancer Patients

  Lin, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Integrative Studies on Falls, Osteoporosis, and Fractures in Older People

  Lin, M.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Genetic Polymorphisms of Calcium Channel in the Risk of Breast Cancer

  Chang, W.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Microrna Let-7g in Cytosolic Ca2+ Regulation and Cox-2 Gene Expression

  Chang, W.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Neurotrophic/Neuroprotective Role of Gip in Cellular and Rodent Models of Mild Traumatic Brain Injury.( I )

  Lin, J. & Chen, R.

  8/1/12 → 7/31/13

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Investigation of the Molecular Mechanisms of a Novel Finger Protein, Znf179, in Neuronal Differentiation

  Lee, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Study of Diffusion Tensor Imaging as a Potential Surrogate Marker for the Management of Acute Ischemic Cerebral Stroke: a Clinical and Animal Model at 7t

  Chen, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Study on Trans-Neuronal Striato-Nigral Degeneration-Induced Movement Disorders after Stroke: Evaluation with Grey Matter Suppression Ir and Diffusion Tensor Imaging( I )

  Chen, C.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of the Involvement of Micrornas in Pressure-Induced Initial Renal Fibrosis

  Chen, T.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role and Molecular Mechanism of Pparα in Acute Kidney Injury: Focus on the Protective Effect in Renal Tubular Cell

  Hsu, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Laser Enhancement of Transdermal Delivery of Nanoparticles

  Lee, W.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of DDX3 in Human Papillomavirus-Infected Lung Tumorigenesis

  Lee, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Chemokine Factors Concomitantly Induce Prostate Cancer Organ Specific Bone Metastasis

  Sung, S.

  8/1/12 → 9/30/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Targeting Hif-1α by Zebularine for the Treatment of Colorectal Cancers

  Yang, P.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Klf10 Alters Metabolic Pathways in Genetic-Deficient Mice and Human Pancreatic Ductal Carcinomas

  Chang, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Influence of Political and Economic Characteristics on Infant Mortality and Under-Five Mortality Rates

  Chuang, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology