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• Glucagon-Like Peptide-1 in the Regulation of PPARs and Calcium Handling in Hyperglycemia or Hypertensive HL-1 Cells

  Huang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• TMU101-AE1-B65

  Wang, T.

  8/1/13 → 7/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• Studies on a Thermosensitive Hydrogel of Doxorubicin as Locally Controlled Delivery of Cancer Therapeutics

  Ho, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Moderating Effect of Welfare States on Health and Service Utilization - Comparison of Taiwan and European Countries

  Chuang, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• End-of-Life Care for Elderly with Advanced Dementia in Long-Term Care Facilities

  Chang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular Mechanism Underlying Progesterone-Regulated p27 Gene Expression

  Hsu, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Saliva Alkaloids of Areca Nut or Tobacco, Inflammatory and Antioxidants Status and Oral Hygiene in Periodontitis Patients

  Huang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• In vitro and in vivo evaluation for silk fibroin-coated electrospun resorbable poly(lactic acid) GTR barriers

  Yang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Application of Fluoxetine and Its Related Medicines in Brain Tumor Treatment

  Shen, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抗氧化防禦基因標籤單核?酸多形性、氧化壓力生物標記與冠狀動脈心臟病之相關性(1/2)

  Yeh, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Blood Sugar Regulation and Molecular Mechanism by White Potato Extract

  Li, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dementia Care and Quality Improvement

  Chien, L.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Activating Transcription Factor 3 in the Protective Effect of Resveratrol in Cardiomyocytes

  Liu, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Investigate the Functions of Shikonin and Its Derivatives in Applied Age-Related Macular Degeneration and Wound Healining

  Cheng, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Huntingtin-Associated Protein-Regulated Biomarkers in Neurodegenerative Diseases

  Lin, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• TMU101-AE1-B63

  Chen, C.

  8/1/13 → 7/31/14

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• Immune Alteration and Immunogenic Cell Death in Advanced Non-Small Cell Lung Cancer Patients

  Feng, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Motor Vehicle Injuries and Screening Tools of Unsafe Driving in Older Drivers

  Lin, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cellular and Molecular Mechanisms of Nicotine and Nitrosamines Promote Tumorigenic Behaviors in Renal Cell Carcinoma (Ii)

  Cheng, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dissected the role of alpha-7 nicotinic receptor in the prognosis and clinical therapy on gastric cancers

  Chang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Metabolic Abnormalities on Cognitive Function in Schizophrenic Patients

  Lu, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Expressing Membrane Antibody Reporter in the Islet Cells of Nonobese Diabetic Mice to Noninvasive Assess the Therapeutic Effects of Drugs or Transgenes for Autoimmune Diabetes

  Chuang, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Functional Role of Growth Factor-Induced Metabolic Enzymes Expression in Cancer Cell Anti-Oxidation and Drug Resistance

  Chang, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of HBX and IL-6 in Regulating SENP1/Stemness Properties of HBV-Related Hcc under Hypoxia and Its Clinical Implication

  Huang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of the mechanism of HPV involved tumorigenesis through Wnt signaling pathway related microRNA regulation

  Cheng, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Electroconvulsive Therapy on Health Services Utilization, Positive and Negative Syndrome, and Sleep among Psychiatric Patients

  Chung, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Anti-Tumor Mechanisms of a Novel Aliphatic Hydroxamate, WMJ-S-001---Targeting Tumor Angiogenesis and Lymphangiogenesis

  Hsu, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Association between lipid, glucose related genes and prognosis of intra- and extra-cranial stenosis in stroke patients

  Chiou, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Enhancement of immuno-modulatory capacity by shear stress in mesenchymal stem cells

  Ho, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Music Listening on Pain, Heart Rate Variability and Joint Range of Motion for Patints Receving Total Knee Replacement

  Lin, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular and cellular mechanism of adipocyte modulatory effects on pulmonary vein and atrium

  Chen, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Functional Role of Transcription Factor Sp1 in Brain Neuronal Injury (II)

  Chang, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dietary Advanced Glycation Endproducts Are Associated with the Development of Polycystic Ovary Syndrome: The Mechanisms of Action

  Hsia, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of glutamine supplementation on T cell homeostasis and inflammatory response in inflammatory bowel disease

  Yeh, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects and Regulation of Oxidize Low Density Lipoprotein and High Density Lipoprotein on Human Endothelial Progenitor Cells

  Huang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討不同選擇作用之組織蛋白去乙醯酶調節成分抑制神經發炎之機制及其對腦內出血與腦炎之治療特性評估(1/3)

  Hsiao, G.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• α9-型尼古丁乙醯膽鹼受體在乳癌幹細胞的角色與防治藥物的篩選

  Lai, G.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Genomic and non-genomic estrogen effects on the spinal NR2B-related uterus-colon crosstalk in rats

  Lin, T.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Epigenetic Control of IL-6-STAT3 Targeting Dnas in the Cell of Dihydropyridine-Induced Gingival Overgrowth

  Lu, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 晚期乳癌組織中尼古丁受體(α9-nAChR)表現與Trastuzumab (Herceptin®)產生抗藥性之分子機制探討

  Ho, Y.

  8/1/13 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Development of Vector-Borne Disease Forecasting Models Using Satellite Remote Sensing Techniques

  Chuang, T.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Plant metabolomics (1. Agave sisalana, 2. Anoectochilus formosanus, 3. phalaenopsis spp.)

  Lee, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Innate Immune Modulator: Molecular Characterization of Bupleurum kaoi Polysaccharide Fraction and Assessment of its Immunomodulatory and Antiviral Effects

  Lin, L. T.

  11/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Ffects of Different Sources of n-3 Fatty Acids on Bone Loss, Body Fat and Inflammatory Markers in Osteoporotic Condition with Diabetes

  Chiu, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Molecular and Clinical Role of microRNA in Obesity Induced Nephropathy

  Lin, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Androgen on Breast Cancer Development and Treatment

  Lin, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Association of Epidermal Growth Factor Receptor mutations with HPV16/18 E6 Oncoprotein Expression in Non-Small Cell Lung Cancer

  Lee, H.

  8/1/13 → 7/31/14

  Project: C - Project of Alliance › r - Tung's Taichung MetroHarbor Hospital

• Evaluation on Cervical Cancer Prevention and Treatment Policy in Taiwan

  Tang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Sleep and Memory Consilidation in Alzheimer Disease

  Hu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology