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  Study the Klf10 alters metabolic pathways in genetic-deficient mice and human pancreatic ductal carcinomas

  Chang, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Nutrients Supplementation on Damaged Mitochondria and Their Biogenesis and Turnover

  Hsieh, R.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Synthesis and Antihyperglycemic Evaluation of Isosteviol Derivatives

  Lin, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• An association study of arsenic exposure, inflammation, oxidative stress and the risk of developing cardiovascular diseases

  Hsieh, F.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on a Thermosensitive Hydrogel of Doxorubicin as Locally Controlled Delivery of Cancer Therapeutics

  Ho, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Vector-Borne Disease Forecasting Models Using Satellite Remote Sensing Techniques

  Chuang, T.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Analysis and Data Mining of Decision Characteristic of Prehospital Emergency Patients Transport

  Hsu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Association Study of Genetic Polymorphisms of Toll-Like Receptors on Ischemic Stroke (I)

  Chiou, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Proteomic Study of Metformin on Kidney Damage in Rats

  Lee, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of LED Light on Porphyromonas gingivalis in Periodontitis for Anti-Inflammation and Alveolar Bone Regeneration

  Deng, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抗發炎藥物與生物製劑藥物對類風濕性關節炎病人發生惡性腫瘤之影響：健保資料庫分析研究

  Chen, S. H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The association of early-onset ischemic stroke and the aging of vascular system using the telomere length related genes

  Hsieh, F.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討小泛素蛋白酶Sentrin-specific protease 2 參與轉型生長因子-beta訊息傳遞的作用機制(1/2)

  Chang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Plant metabolomics (1. Agave sisalana, 2. Anoectochilus formosanus, 3. phalaenopsis spp.)

  Lee, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploring Biopathways Related to Cancer Based on Differences of Gene Expression between Cancer and Normal Situation

  Chiu, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors

  Lee, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• he Effects of the APOE4 Allele on cerebral Structural and Functional Connectivity- A Diffusion Tensor Imaging and Resting-state MRI study

  Chen, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Antibody-Mediated Immune Suppression of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)

  Burnouf, T. P. R.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Novel activities of gamma-aminobutyric acid-mediated regulation of platelet activation, apoptosis, and autophagy: the non-genomic functions of NF-kappaB signal in anucleated cells

  Sheu, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Functional Role of Growth Factor-Induced Metabolic Enzymes Expression in Cancer Cell Anti-Oxidation and Drug Resistance

  Chang, W.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Functional Electrical Stimulation on the Study of Nerve Regeneration in the Rat with Diabetic Neuropathy

  Peng, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Deferasirox Plasma Concentration Analysis and Effects of Potential Iron Chelators on Iron Overload and Safety Evaluation

  Wu, T.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用三段式螢光共振能量轉移觀察基因藥物與聚合微膠體在不同角膜分佈穿透(2/3)

  Liaw, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Hyaluronic Acid and Resveratrol Modified Carbon Nanotube Scaffolds for Tissue Engineering

  Sheu, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Therapeutic Strategies for Traumatic Brain Injury with Novelly Desinged Drugs (II)

  Wang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Investigate the Functions of Shikonin and Its Derivatives in Applied Age-Related Macular Degeneration and Wound Healining

  Cheng, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Anti-Tumor Mechanisms of a Novel Aliphatic Hydroxamate, WMJ-S-001---Targeting Tumor Angiogenesis and Lymphangiogenesis

  Hsu, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation on developing novel biomarkers and treatments in the patients with fibromyalgia

  Kang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Sleep and Memory Consilidation in Alzheimer Disease

  Hu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating of Transcranial Direct Current Stimulation and Robot-Assisted Gait Training Effects in Subjects with Stroke

  Lai, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Sumoylation of Histone Deacetylase 2 Contributes to CTGF Expression and Pulmonary Fibrosis in Chronic Obstructive Asthma (I)

  Lin, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Electroconvulsive Therapy on Health Services Utilization, Positive and Negative Syndrome, and Sleep among Psychiatric Patients

  Chung, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Writing for Scholarly Publication in English for Researchers in the Fields of Social Sciences, Natural Sciences, Engineering, and Medicine in Higher Education in Taiwan

  Chien, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Using Cometing Risk Model for Death and Multi-state Stochastic Process for the Behaviour of Betel-quid Chewing and Smoking to Estimate the Potential Years of Life Lost Due to Betel Quid and to Estiamte the Impact of Qutiing Betel-quid chewing

  Yen, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Epigenetic Control of IL-6-STAT3 Targeting Dnas in the Cell of Dihydropyridine-Induced Gingival Overgrowth

  Lu, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Victorian Sanitation: Narratives of Poverty, Filth and Economy of Morality

  Chen, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Gender Analysis of Workplace Violence among Medical Care Personnel

  Chen, R.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Exercise Training on Sleep Disturbances, Anxiety, and Depression among Newly Diagnosed Elderly Lung Cancer Patients

  Lin, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of a program of mind-body interventions on psychological resilience, vagal tone, emotional states, and outcomes of heart failure

  Tsai, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• A series of studies analyzing exercise behavior and exploring the effects of interventions among pre-diabetes, type 1, and type 2 diabetes

  Jeng, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Music Therapy on Psychological Distress and Functional Recovery in Patients With Stroke

  Chang, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular Epidemiology of Urothelial Carcinoma Prognosis Based on Microrna Expression Profiles

  Wang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Neurofeedback and Rsa Biofeedback on Quality of Sleep in Patients in the Chronic Phase of Traumatic Brain Injury

  Tsai, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The role of DDX3 in human papillomavirus-infected lung tumorigenesis

  Lee, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploring the effects of an exercise program on female diabetic patients$ health

  Liao, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Electrophysiological and Molecular Insights into the Cardiac Regulations of ZFHX3 Gene---Implication in the Pathophysiology of Atrial Fibrillation

  Chen, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Discovery of Rare and Common Variants in Genetic Association Studies

  Cheng, K.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Reflex Pelvic Floor Muscle Activities in Women with Urinary Incontinence (II)

  Yang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Study the Correlation between Serum Markers of Oxidative Stress, Inflammation, and Endocrine-Disrupting Chemicals (Edcs) and Their Impact on the Menstrual Cycle and Reproductive Hormone in Taiwanese Women

  Hsu, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology