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探究腦指蛋白 ZNF179 (Brain Finger Protein) 的分子機制

Huang, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Study on the Immuno-Modulatory Effects of Notch Ligand Delta 4 on Immune Cells and in Ova-Induced Asthmatic Mice

Lee, Y.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Preparation and Evaluation of Tea Polyphenol Contained Nanocarriers for Ophthalmic Application

Tseng, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

睡眠困擾是癌症病人最常主訴的問題之一。患有睡眠困擾之癌症病人經常同時伴隨 疲憊、憂鬱等現象發生,形成症狀群集,影響生活品質。雖然目前對於癌症病人睡眠障 礙之量性研究已多有著墨,然而對於癌症病人經歷睡眠障礙之主觀經驗之瞭解,仍相當 有限。瞭解病人經歷睡眠障礙之主觀經驗,將有助於未來睡眠評估工具之修訂。另外, 在評估癌症病人睡眠品質時,若能以簡單工具評估,會更具效率及助益。阿森斯失眠量 表(Athens Insomnia Scale, AIS) 是一個簡單的8 題問卷,廣為使用在一般失眠的病人, 在癌症病人使用上,尚未有豐富的實證資料,若能建立其在癌症病人的信效度,將可作 為一簡單篩檢癌症病人失眠的工具。 睡眠遵行日夜節律規則,日夜節律又需要光作為矯正的線索,光在癌症病人睡眠的 角色,尚未有研究證實,過去研究顯示癌症病人睡眠品質不佳與生物節律有關係。光是 重要日夜節律的線索,光療法透過褪黑激素調節,調整日夜節律週期,可能可以改善睡 眠品質。另外,由於,睡眠障礙、憂鬱、疲憊經常形成一症狀群集,光療法於改善睡眠 障礙之同時,是否亦同時改善憂鬱、疲憊及生活品質。目前,光療法在癌症病人的運用 上,付之闕如,故建立光療法於癌症病人的有效性值得探究。 本研究為三年期研究計畫,目的包括有:1.瞭解癌症個案對於睡眠困擾的主觀經驗 (第一年)。2.建立阿森斯失眠量表中文版的信效度、敏感性、特異性(第一年)。3.瞭 解癌症病人光暴露與生物節率、睡眠障礙的關係(第二年)。4.瞭解光療法對於改善癌 症病人睡眠障礙及相關症狀群集、及生活品質之成效;以及瞭解光療法影響褪黑激素之 程度(第三年)。 本研究擬以癌症住院及門診病人為對象,研究工具包括基本資料、匹茲堡睡眠品質 問卷、阿森斯失眠問卷,簡明疲憊量表,貝克憂鬱量表度、SF-36 生活品質量表、腕動 力器等。資料處理分析方式包括:內容分析、描述性統計、t 檢定、皮爾森相關、GEE (generalized estimating equations)等。 本研究之結果將可瞭解光暴露與生物節率與睡眠障礙之間的關係,並可進一步瞭解 光療法作為改善癌症病人睡眠障礙之護理措施之成效,以期,最終能藉由改善癌症病人 之睡眠品質提昇病人之生活品質。

Lin, C.

8/1/1210/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Exploitation of Taiwan Native Plants in Promoting Bone Growth and Establishment of the System Biology Platform

Lee, M.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Dissected the Role of Alpha-7 Nicotinic Receptor in the Prognosis and Clinical Therapy on Gastric Cancers

Chang, Y.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of DDX3 in Human Papillomavirus-Infected Lung Tumorigenesis

Lee, H.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Oral Health and Interventions for Elderly in Long-Term Care Facilities

Chang, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of Exercise Training on Sleep Disturbances, Anxiety, and Depression among Newly Diagnosed Elderly Lung Cancer Patients

Lin, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Pulmonary Effects of Chorioamnionitis and Postnatal Hyperoxia in Rat Offspring

Chen, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Macro and Micro Biomechanical Studies of Soft Tissue Remodeling under Tissue Expansion (II)

Chen, H.

8/1/121/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Studies of Cxcl12 in Hypoxia-Induced Pulmonary Fibrosis

Chen, B. & Chung, C.

8/1/127/31/13

Project: B - Project of TMUh - Other (Funded by TMU)

Translational Genomic Approaches in Endometriosis

Tzeng, C., Kao, S., Huang, Y., Yang, W., Yang, W., Yeh, C., Li, Y. & Shen, S.

8/1/1210/31/13

Project: B - Project of TMUh - Other (Funded by TMU)

Studies on the Carcinogenic Mechanisms of Histamine N-Methyltransferase-Mediated Breast Cancer Formation

Wu, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of Indoor Air Quality Improvement on Cardiovascular Health in General Population

Chuang, K.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Degradation of Nitrogen-Containing PPCPs: Kinetic Study, Application, and Balancing the Toxicity of N-DBP and Intermediates through Bioassay

Chang, E.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

CAAT/enhancer binding protein beta訊息路徑參與thrombin誘導人類肺部上皮細胞IL-8/CXCL8表現之研究

Chen, B.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

NF-kB以及NF-kB repressing factor (NRF) 在慢性阻塞性肺疾病引發系統性發炎之角色探討(3/3)

Lee, K.

8/1/1210/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

榖胱甘月太硫轉移酉每參與乳癌致癌之分子機制探討(1/3)

Wu, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Genetic Polymorphisms of Calcium Channel in the Risk of Breast Cancer

Chang, W.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Renoprotective Mechanisms of Soy Protein in Rats with Diabetic Nephropathy

Chen, J.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation

Liang, Y.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

21世紀的公民與風險:全球變遷中的環境,知識和價值

Chiou, H.

8/1/1212/31/13

Project: A - Government Institutiond - Ministry of Education

Chemokine Factors Concomitantly Induce Prostate Cancer Organ Specific Bone Metastasis

Sung, S.

8/1/129/30/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of Cd69 in Tnfalpha-Inhibited Erythroid Differentiation

Huang, H.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Lay Health Knowledge Research:Example of Infants and Children Dietary Supplement

Chen, Y. C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Epigenetic Regulation of Lps-Induced G-Csf Expression in Macrophages

Chang, S.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Roles of Micrornas in Endothelin-1 and Hypoxia-Induced Ctgf Production

Chen, Y.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Huntingtin-Associated Protein Related Biomarkers in Neural Survival

Lin, Y.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

In vitro and in vivo Evaluation for Silk Fibroin-Coated Electrospun Resorbable Poly(Lactic Acid) GTR Barriers

Yang, J.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

依療法律與醫學倫理

Ho, J.

8/1/121/31/13

Project: A - Government Institutiond - Ministry of Education

Translational Genomic Approaches in Endometriosis

Tzeng, C.

8/1/1210/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Design and Evaluation of a Novel Drug-Containing Ceramic Hydrogel for the Healing of Alveolar Bone Defect

Lee, S.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Enhancement of Immuno-Modulatory Capacity by Shear Stress in Mesenchymal Stem Cells

Ho, J.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Motorcyclist Behavioural Patterns to Pedestrian Green Signal Countdown Device (Pgscd): a Mixed Logit Analysis

Pai, C.

8/1/129/30/13

Project: A - Government Institutionb - Ministry of Science and Technology

Association between Lipid, Glucose Related Genes and Prognosis of Intra- and Extra-Cranial Stenosis in Stroke Patients

Chiou, H.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Advanced Research for a Decision Model of Emergency Patient Intelligent Dispatch

Hsu, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Study the Klf10 Alters Metabolic Pathways in Genetic-Deficient Mice and Human Pancreatic Ductal Carcinomas

Chang, H.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Effect of Blood Sugar Regulation and Molecular Mechanism by White Potato Extract

Li, S.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The First Randomized Controlled Clinical Trial for Computerized Decision Support System (II)

Li, Y.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology