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• b - Ministry of Science and Technology

  Investigating the Therapeutic Potential and Molecular Mechanism of Natural Products for Platinum-Resistant Bladder Cancer(1/3)

  Chen, M.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建置與評估可擴充式機器學習演算法之重症醫療資訊平台

  Lo, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討CDK4/6抑制劑在兒童惡性腦瘤治療的可行性(第二年)(2/3)

  Hsieh, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Smart Mouth Guard 3D Drug Delivery and Wound Dressing Device Development (Project 1)

  Deng, W. & Ou, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Predict the Recurrence of Major Depressive Disorder Within an Integrated Bio-Psycho-Social Framework---A Follow-up Study

  Lee, H.

  8/1/15 → 10/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

  Wang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Health Risk Behaviors on Recurrent Traffic Injury

  Chen, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Antibody-Mediated Immune Suppression of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)

  Burnouf, T. P. R.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Islide - a Global Community E-Learning Online

  Li, Y. & Jian, W.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Roles of Autophagy and Heme Oxygenases(-1, -2) in Brain Injuries: in Vivo and in Vitro Studies

  Wang, J. & Wu, C.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploring the Potential Impact of Periodontitis on the Induction or Development of Parkinson’S Disease: Utilizing Platelet Lysate as a Possible Therapeutic Strategy( I )

  Chang, H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the Mechanism Involved in Nanoparticles-Induced Tight Junction and Aquaporins Damages in Endothelial Cells, as Well as the Effects on Physiological Function of Endothelial Barriers

  Li, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Molecular Biological Mechanism of Fish Oil on Preventing Alcoholic Liver Diseases: the Hepatoprotective Effects of Epa and Dha Based on Lipid Metabolism, Autophagy and Inflammatory Responses

  Yang, S.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Physiological Predictors of Concurrent Cardiovascular Diseases in Schizophrenia

  Chen, P.

  8/1/16 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 醫學人文課程之執業場域體驗學習對低年級醫學生醫療專業素養養成之影響

  Tang, K.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Mirna and Gut Microbiota in Pathogenesis of Post-Stroke Vascular Cognitive Impairment

  Chiou, H.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Balance Control and Motor Strategies in the Elderly with Cognitive Impairments: 3d Motion Analysis, and the Development and Efficacy of a Home-Based Wearable Dual-Task Training Device

  Kuan, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Building the Smart Early Intervention Service

  Tseng, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Novel Lifr Axis in Metabolism Unhinged and Neuroendocrine Differentiation of Prostate Cancer(I)

  Liu, Y.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of an Emergency Medical Capability Ranking Mechanism to Improve the Mass Casualty Distribution System’S Resilience

  Chuang, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 流感疫苗與致死性心律不整之回溯性世代研究與視覺探索平台建置：以全國性縱貫資料中慢性阻塞性肺病老年患者為研究對象。

  Hung, H.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• CXCL6/CXCL1 axis在PDK1訊號路徑介導的放射抗性肝細胞癌之分子機制探討

  Tsai, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Discovery of Agents Disturbing Genome Stability during Chromatin Replication

  Lee, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 管理階層政商關係對生物科技公司首次公開募股後辦理首次現金增資期程之影響

  Hsiao, Y.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 奈米生物介面研究：中孔洞氧化矽奈米粒子性質及其蛋白質冠冕於抗聚乙二醇免疫性、腫瘤標靶效率及腎臟排泄的影響(2/2)

  Wu, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Ultra-Compliable and Biodegradable Wireless Stem Cell-Embedded Microelectrode Arrays Appied for Electrically-Manipulable Central Neural Tissue Regeneration( I )

  Huang, W.

  2/1/19 → 1/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 骨質疏鬆及肌少症影像人工智能分析計畫

  Kuo, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討慢性睡眠剝奪對口腔菌叢的影響，並闡明口腔菌叢引致認知功能失常的潛在機制

  Chang, H.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Neural and Glutamatergic Correlates of Resting State Activity and Stimulus-Induced Activity in Major Depressive Disorder---Can Multimodal Imaging (fMRI and MRS) Reveal Therapeutic Predictors?

  Chen, C., Lane, T. J., Hu, C., Tseng, Y. & Lee, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Reconstitution of Spermatogenesis from Testis Failure after Spermatogonial Stem Cells (Ssc) Transplantation for Male Fertility Preservation-A Transgenic Mouse Model

  Chen, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Muscle Strength Training on Body Composition and Sarcopenic Obesity among the Female Overweight Elderly

  Liou, T.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Renoprotective Mechanisms of Soy Protein in Rats with Diabetic Nephropathy

  Chen, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Islide - a Global Community E-Learning Online

  Li, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Maternal Depressive Symptomatology on Pregnancy Outcomes and Newborn Development---How Is Paternal Psychopathology Involved?

  Chen, Y., Hsu, C., Lin, H. & Huang, K.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Function and Regulation of miRNAs in Pancreatic Cancer Progression (II)

  Huang, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展"亞洲健康識能學會"與亞洲及國際合作推動全球衛生醫療照護品質之提升 (2/3)

  Chang, W.

  1/1/16 → 12/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討TCF7L1對前列腺癌神經內分泌分化之分子機轉與臨床意義

  Wen, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 開發蛋白質雙硫鍵異構酶抑制劑作為抗多形性神經膠質母細胞瘤藥物

  Huang, W.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討轉移肺癌病患初始診斷後與死亡前之醫療資源耗用情形及相關影響因子

  Chien, L.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 可降解鎂基金屬玻璃做為運動醫學修復手術縫合錨釘之研究開發

  Chen, C.

  5/1/20 → 4/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Early Detection and Genetic Risk Factors of Hearing Impairment

  Lin, I.

  3/1/20 → 2/28/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of C3H-Type Zinc-Finger Proteins on the Down-Regulation of Ubiquitination-Mediated Activation of Signal Transduction

  Liang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular Ivestigation of the Electron Transfer Flavoprotein Dehydrogenase Mutation Induced Mitochondrial Dysfunction and Metabolic Defects

  Kao, S. & Hsu, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Innovation Communication Education in Veterinary Medicine: a Client-Centered Model

  Hsu, Y.

  10/1/13 → 9/30/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 外科系醫學(一)學門規劃研究推動計畫

  Wu, C.

  1/1/13 → 12/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the Mechanisms of a9-Nicotinic Acetylcholine Receptor Confers Tamoxifen-Induced Drug Resistance in Human Breast Cancer Cells

  Ho, Y. & Wu, C.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Narratives of History, Anxiety, and Incapability in Ian Mcewan$S Later Novels

  Chen, C.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploring the Potential Impacts of Maternal Early-Life Sleep Deprivation on Metabolic Function of the Offspring( I )

  Chang, H.

  8/1/16 → 8/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effectiveness of Mindfulness-Based Cognitive Therapy (Mbct) for Patients with Depressive Disorders

  Chang, H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology