Find Research Projects

Search results

• b - Ministry of Science and Technology

  Investigation the Functional Role of Extracellular Matrix Protein, Nephronectin, in the Renal Proximal Tubular Cell Tight Junction Formation (Ii)

  Cheng, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • nephronectin 100%
  • Tight Junctions 31%
  • Renal Cell Carcinoma 30%
  • Neoplasm Metastasis 14%
  • Kidney 12%

• Investigation of the Molecular Circuit Directing Mtg8-Mediated Angiogenesis during Tumor Progression

  Hwang, W.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• A High Density and Nano-Sized ReRAM Crossbar Array Using Copper Chemical Displacement and Nanotip Array Techniques (I)

  Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • random access memory 100%
  • diodes 21%
  • copper 13%
  • schedules 11%
  • nitrides 8%

• The Molecular Basis of Senp2 in Regulating Smad4 Sumoylation and Its Functions in Triple Negative Breast Cancer

  Chang, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • SUMO-1 Protein 100%
  • Transforming Growth Factor beta 99%
  • Peptide Hydrolases 83%
  • Sumoylation 26%
  • Triple Negative Breast Neoplasms 23%

• ALA Photodynamic Therapy, Tumor Hypoxia, CSE1L Phosphorylation, and the Progression and Treatment of Skin Cancer

  Lee, W.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Skin Neoplasms 100%
  • Aminolevulinic Acid 31%
  • Tumor Hypoxia 25%
  • Neoplasms 24%
  • Photochemotherapy 20%

• Functional Evaluations on Immunomodulatory Activities of Different Protease Hydrolysates and Isolated Peptides from Yam Storage Proteins, Dioscorin

  Hou, W.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • peptides 100%
  • hydrolysates 86%
  • proteinases 44%
  • yams 35%
  • storage proteins 32%

• New Strategy in Natural Product Research---A Rapid Analysis and Rapid Activity Screening Platform

  Lee, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • screening 100%
  • bioactive compounds 99%
  • environmental protection 43%
  • endophytes 36%
  • animal models 31%

• Therapeutic Implications of Down-Regulation of Microglia Activation Following Repetitive Traumatic Brain Injury-Induced Chronic Traumatic Encephalopathy

  Chang, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Traumatic Brain Injury 100%
  • 1-(3',4'-dichloro-2-fluoro(1,1'-biphenyl)-4-yl)cyclopropanecarboxylic acid 84%
  • Chronic Traumatic Encephalopathy 64%
  • Alzheimer Disease 35%
  • Microglia 22%

• 嘌呤類似物對阿茲海默症模型小鼠的療效評估

  Lin, Y.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展可標靶樹突細胞之mPEG-PLGA/PLGA-PEG-PLGA混和水膠體的奈米顆粒癌症疫苗用於癌症免疫療法(2/3)

  Ho, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Taiwan Fall-Risk Screening Tool for Community-Dwelling Older People and a Randomized Controlled Trial of Fall Prevention in the Cognitively Impaired

  Lin, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Accidental Falls 100%
  • Taiwan 24%
  • Cognitive Dysfunction 20%
  • Risk Assessment 15%
  • Independent Living 12%

• Development of Taiwan Fall-Risk Screening Tool for Community-Dwelling Older People and a Randomized Controlled Trial of Fall Prevention in the Cognitively Impaired(3/3)

  Lin, M.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Accidental Falls 100%
  • Taiwan 24%
  • Cognitive Dysfunction 20%
  • Risk Assessment 15%
  • Independent Living 12%

• 設計及合成香豆素衍生物作為單羧酸轉運蛋白 MCTs抑制劑之活性研究

  Lin, M.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Identification of Genomic Markers and Immune Repertoires for Combinations of Immunotherapy with Metronomic Chemotherapy or Radiofrequency Thermal Ablation in Pancreatic Ductal Adenocarcinoma( I )

  Chang, W.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新穎小分子抗多發性骨髓瘤藥物機轉研究

  Huang, W.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Scaffold in Ovarian Transplantation for Female Fertility Preservation---An in vivo Transgenic Mouse Model (I)

  Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • angiogenesis 100%
  • sphingosine 55%
  • tissue engineering 47%
  • ischemia 45%
  • animal models 35%

• Exploring the Potential Applications of Dna Mimic Protein Saugi in Viral Diseases and Mrsa by Structure-Based Study

  Wang, H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Uracil-DNA Glycosidase 100%
  • Simplexvirus 47%
  • Staphylococcus aureus 37%
  • vpr Gene Products 35%
  • Human Immunodeficiency Virus Proteins 29%

• Design and Preclinical Translation Study of Mixed-Bispecific/Trispecific Antibody for Enhancing Therapeutic Effectiveness of Anticancer Drug-Loaded Pegylated Nanocarriers by Simultaneously Targeting to Tumor Cells and Cancer/Tumor Associated Fibrobla

  Sheu, M.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Targeting Hepatitis C Virus-Induced Hepatocellular Carcinoma with Precision Medicine-Tailored Oncolytic Measles Virus(1/3)

  Lin, L. T.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the Mechanisms of Dna Primase（Prim1）Involved in Smoking-Induced Breast Cancer Formations and Its Translational Applications

  Chen, L.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Anti-Α9nachr/Anti-Polyethylene Glycol Bispecific Antibody to Enhance the Therapeutic Efficacy of Nano-Drugs against Breast Cancer( III )Development of Anti-Α9nachr/Anti-Polyethylene Glycol Bispecific Antibody to Enhance the Therapeutic Efficacy of Nano-Drugs against Breast Cancer( III )

  Chuang, K.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of C3H-Type Zinc-Finger Proteins on the Down-Regulation of Ubiquitination-Mediated Activation of Signal Transduction

  Liang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Ubiquitin 100%
  • Ubiquitination 71%
  • Lysine 32%
  • Zinc Fingers 28%
  • Signal Transduction 25%

• 運用資料探勘建立長期用藥與癌症發生之個人化風險矩陣(2/2)

  Yang, H.

  2/1/21 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Ultrasound-Guide Hypertonic Dextrose Injection for Chronic Subacromial Bursitis

  Huang, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用大型基因資料庫及臨床收案，探討台灣族群ITPKC基因變異在氣喘之角色

  Chang, W.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 開發1,3-二芳基取代之五元雜環作為抗胰臟癌劑(2/3)

  Lee, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展三功能抗體(EGFR/CD3/mPEG)修飾之聚乙二醇-免疫增敏奈米藥物以主動標靶毒殺大腸癌並同時強化體內 T 細胞於腫瘤微環境抗癌功效之創新協同療法-發展新型聚乙二醇-免疫增敏奈米藥物載體以毒殺大腸癌並強化腫瘤區域T細胞之抗癌功效(1/3)

  Liu, D.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 絲氨酸/蘇氨酸蛋白激酶(SIK3)參與乳癌致癌過程的分子機制探討

  Chen, L.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 結合奈米診斷治療、影像免疫基因圖譜與人工智慧於原發性與再復發膠質母細胞瘤之研究-建立原發性和再復發膠質母細胞瘤免疫圖譜以及建立免疫療法(2/3)

  Lee, G.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Protective Role of Hmg-Coa Reductase Inhibitor，Statins，In Postoperative Complications and Survival of Critically Ill Subjects(2/3)

  Chen, T.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 產學合作計畫－產學研發中心計畫—微整型生醫材質產學研發中心(1/3)

  Sheu, M.

  7/1/20 → 6/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Novel Activities of Gamma-Aminobutyric Acid-Mediated Regulation of Platelet Activation, Apoptosis, and Autophagy: the Non-Genomic Functions of Nf-Kappab Signal in Anucleated Cells

  Sheu, J.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • gamma-Aminobutyric Acid 100%
  • Blood Platelets 65%
  • Platelet Activation 27%
  • Mitochondrial DNA 26%
  • Autophagy 20%

• Depression Trajectories in Women – a Developmental-Ecological Approach (Gm03)

  Kuo, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Depression 100%
  • Cohort Studies 34%
  • Postpartum Period 24%
  • Longitudinal Studies 21%
  • Retrospective Studies 17%

• Effects of Cafestol on Cardiac Hypertrophy.

  Liu, J.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Identifying Cancer-Stem-Cell-Invadopodia-Related Prognostic Biomarkers in Gastric Cancer

  Chan, T.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Podosomes 100%
  • Neoplastic Stem Cells 71%
  • Stomach Neoplasms 27%
  • Neoplasms 18%
  • Neoplasm Metastasis 11%

• Reconstruction of Vertebral Body with Delayed Posttraumatic Vertebral Collapse---Biomechanical Evaluation and Redesign

  Chen, H.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • vertebrae 100%
  • mechanical testing 50%
  • spine (bones) 47%
  • surgery 43%
  • bones 36%

• Study the Role and Regulation of Dicer in Sorafenib Sensitivity of Liver Cancer

  Chen, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sorafenib 100%
  • Liver Neoplasms 86%
  • Hepatocellular Carcinoma 28%
  • MicroRNAs 14%
  • Neoplasms 13%

• 高溫與過氧化氫對於誘發呼吸道反射的增效作用:肺C型感覺神經細胞的角色(1/2)

  Hsu, C.

  11/1/16 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Primase, DNA, polypeptide 1（PRIM1)參與吸菸所誘發乳癌形成機制及臨床轉譯研究(1/3)

  Chen, L.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating the Dynamic Change of Genotype and Phenotype in Circulating Tumor Cells and Its Clinical Significance in Cancer Progression

  Lee, H.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 從食安風險暴露之角度探討非營養性甜味劑對女性生殖狀況之影響-非營養性甜味劑對青春期早發育的影響及相關機轉探討(1/3)

  Chen, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Targeting Kdm4a in Prostate Cancer(III)(3/3)

  Kung, H.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 嵌合抗原受體T細胞用於治療人類卵巢癌的免疫療法(2/3)

  Liu, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Three Steps of Fluorescence Resonance Energy Transfer Observation of Complexation of DNA/Drug/Polymeric Micelles on Cornea Transport

  Liaw, J.

  8/1/14 → 12/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Micelle 100%
  • Fluorescence Resonance Energy Transfer 69%
  • Fluorescence 18%
  • Antiapoptotic 18%
  • Donor 13%

• 探討短鏈脂肪酸抑制造成過敏作用之免疫細胞的調控機制及其對過敏性氣喘疾病之治療特性評估(3/3)

  Lee, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Volatile Fatty Acids 100%
  • Phenylbutyrates 29%
  • Mast Cells 27%
  • Immunoglobulin E 20%
  • Asthma 17%

• Development of Novel Tetracyclic and Heterocyclic Dual Topoisomerases Inhibitors as Anticancer Agents( II )

  Huang, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The First Randomized Controlled Clinical Trial for Computerized Decision Support System (II)

  Li, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Contrast Media 100%
  • Drug-Related Side Effects and Adverse Reactions 60%
  • Clinical Decision Support Systems 56%
  • Physicians 54%
  • Randomized Controlled Trials 43%

• Novel Activities of Gamma-Aminobutyric Acid-Mediated Regulation of Platelet Activation, Apoptosis, and Autophagy: the Non-Genomic Functions of Nf-Kappab Signal in Anucleated Cells

  Sheu, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • gamma-Aminobutyric Acid 100%
  • Blood Platelets 65%
  • Platelet Activation 27%
  • Mitochondrial DNA 26%
  • Autophagy 20%

• Molecular Pathogenesis of Progression of Cerebral toxocariasis into Alzheimer’s-Like Disease Affected by Dysfunctional Regulation from Impaired UPS and ALS That Lead to Aberrant Βeta-Amyloid Generation and Metabolism in Brain

  Fan, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Toxocariasis 100%
  • Toxocara canis 75%
  • Proteasome Endopeptidase Complex 60%
  • Ubiquitin 51%
  • Amyloid Precursor Protein Secretases 45%

• Outcomes research in gout: economic impact, humanistic burden, and pharmacoeconomic evaluation

  Ko, Y.

  1/1/16 → 12/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology