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• b - Ministry of Science and Technology

  智能人類血小板顆粒結合多功能聚合物載體做為新型治療的生物醫學平台(3/3)

  Chuang, E.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Impact of Childhood Trauma Exposure on Social Functioning in Schizophrenia Patients – Role of Plasma Oxytocin as a Biomarker(2/2)

  Goh, K. K.

  5/1/21 → 10/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Structure-Based Design, Synthesis and Biological Evaluation of Novel 6-Substituted 10-Chloro-12h-Thiochromeno[2,3-C]Quinolin-12-One Derivatives as Potential Anticancer Agents

  Huang, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以新穎mito-FD-CRISPR/Cas9系統開發粒線體基因編輯模式

  Lee, C.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討HDAC/LSD1雙效抑制劑對KRAS突變及 5-FU抗藥性大腸癌細胞之治療及機轉研究

  Cho, E.

  7/1/22 → 2/28/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Investigation of the Gutta Percha Temperature Change on Vertical Compaction of Warm Gutta Percha Technique

  Hsieh, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• An Action Research Approach to Clinical Skills Education Development : Using Reflective Writing to Promote the Transformation of Students’ Skill Acquisition toward the Way of Better-Best-Practice

  Lin, W., Chen, C. & Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 慢性肝病在台灣是一個極具挑戰性的臨床議題。肝纖維化的多重病原性是造成病患死亡 率增加的原因，而且肝纖維化往往會發展成肝癌。我們最近利用國民營養調查資料庫 (NAHSIT 2005-2008)分析國人血中鐵營養值標與代謝症候群的相關性.在全人口的分析 中，我們發現校正了血清發炎指標以及飲食的營養指標後, serum ferritin (鐵蛋白質) 高於最大三等分位的族群，得到代謝性症候群的危險對比值超過 1.6 倍. 目前並不清楚 過量的鐵蛋白質為何與代謝症候群的發生率有關。肝臟為重要的儲鐵器官但是臨床研究 也顯示過量的鐵質沉積與肝纖維化及肝癌有極大的相關性。血清中鐵蛋白質為反映體內 儲存鐵的生化質標。但是,發炎因子也會造成血清中鐵蛋白質的異常增加。證據顯示發炎 因子可以調控鐵蛋白質的基因表現量。但是慢性發炎如何造成鐵蛋白質代謝異常(組職 內沉積及釋放)? 血清中的鐵蛋白質又有何生理功能? 隨著國人代謝症候群及脂肪肝發生率的年輕化,這次研究的主題是以老鼠初代星狀肝細 胞來分析鐵蛋白質對內質網壓力機轉與肝纖維化的影響: 相關研究的主要目標為: 1. 釐清鐵蛋白質(serum ferritin)過量是否會造成星狀細胞內質網壓力增加與活化? 2. 何種鐵質(ferric, ferrous, ferritin, Apoferritin)較易增加內質網壓力? 3. 找出何種內質網壓力的轉錄因子 (ATF6,ATF4, XBP1 and CHOP)受到鐵質調控? 4. 分析鐵質誘導的內質網壓力機轉與肝臟纖維化的營響

  Chang, J.

  9/1/12 → 8/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating the Role of Attentional Amplification in Subliminal Auditory Processing in Patients with Schziphrenia: a Behavioral, EEG, Pupillometry, and Mrs Study

  Lin, I.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以粒線體因子NDUFAF5為標的來抑制 5FU抗藥性大腸癌之聯合治療探討及調控機轉分析

  Cho, E.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Clarify the Role of Neurosteroids Metabolism in Drug Resistance in Glioblastoma(1/3)

  Hsu, T.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 臺灣食用油與含油食品縮水甘油酯含量調查與形成機制研究(2/3)

  Lee, W.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立高經濟價值壓榨油混摻指標與品質標準研究-以酪梨油為例

  Lee, W.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 交酯化食用油產品加工程序生成縮水甘油酯之研究

  Lee, W.

  6/1/18 → 5/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 思覺失調症者的聽覺異常與腦中神經傳導物質的關聯(1/2)

  Lin, I.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 釐清神經類固醇的代謝在神經膠質瘤的抗藥性中扮演的角色(3/3)

  Hsu, T.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mitochondrial Dysfunction of Endothelial Cells Derived from Pcos Induced Pluripotent Stem Cells-A Potential Role of Cardiovascular Disorders in Pcos Women( I )

  Ho, H.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studying on the Molecular Mechanism in Which the Nedd8-Mediated Neddylation of Tgf-Β Type II Receptor Triggers the Metastatic Progression and Immune Invasion and Evaluating the Anti-Cancer Effectiveness of Pevonedistat on Lung Adenocarcinoma

  Zheng, J.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Fatty Acid Metabolic Reprogramming Associated with Mitochondrial Dna Mutations in the Drug Resistance of Glioblastoma

  Hsu, T.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Constructing and Validating an Epa-Based Anesthetic Nurse Practitioner Curriculum Map under Hybrid Education (1/2)

  Chen, C.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Thermal Behavior and Canal Systems Obturation Evaluation of a Novel Gutta Percha

  Hsieh, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Heat Treatment Conditions and Lipid Oxidation on the 3-Monochloropropandiol Ester and Glycidyl Ester Levels in Meats: Formation Mechanism and Hazard and Exposure Assessments

  Lee, W.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Formation of Glycidyl Esters during Processes of Interesterified Edible Oil Products

  Lee, W.

  6/1/18 → 5/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 黑豆油開發的最適化策略研究：探討不同加工與儲存方式對營養價值與氧化安定性之影響

  Lee, W.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 釐清神經類固醇的代謝在神經膠質瘤的抗藥性中扮演的角色(2/3)

  Hsu, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Etelcalcetide經由調控DUSP4和TRAF3路徑於慢性腎臟疾病-礦物質骨病變可改善硫酸吲哚酚引起的低骨轉換率(2/3)

  Zheng, C.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Using Metabonomics and Proteomics to Explore the Role and Mechanism of Advanced Glycation End Products in Patients with Multiple Sclerosis

  Lee, J.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Elucidate the Mechanisms, Development and Effectiveness of Balance and Gait after Mild Truamatic Brain Injury: Develop Innovative Design of Computerized Dual-Task Balance Module and Precision Treatment of Transcranial Magnetic Stimulation (Phase 2 and 3)(1/2)

  Lin, L.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Trajectory of Psychological Distress among Infertility Women: Efficacy and Mechanism of Mind-Body Intervention with Heart Rate Variability Biofeedback(2/3)

  Kuo, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 研究新穎長鏈非編碼RNA LINAT在TGF-beta訊息動態及腫瘤惡化的角色(1/3)

  Chen, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Changes of Brain Structural Connectivity and Behaviors in Typical Autism after Teacch Intervention

  Lo, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用長期血液循環腫瘤DNA探討基因變異與前列腺癌復發風險與抗藥性以發展個人化醫療標記之研究

  Shao, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Pharmacological Investigations and the Study of the Potential Biological Effects of Nitric Oxide Releasing Nano-Carrier System in Blue Light Induced Retinopathy(II)(2/3)

  Cheng, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Pharmacological Investigations of Phenylethanoid Glycosides in Blue Light and N-Retinylidene-N-Retinylethanolamine Induced Retinal Degeneration and Their Protective Effects in Retinopathy

  Cheng, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dysmetabolic Iron Overload Syndrome and Testosterone Biosynthesis: Role of Fat and Iron Enriched Diet(2/3)

  Chang, J.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Using Machine Learning Technologies to Develop a Smart System for Predicting Nstemi Patients Re-Admission Within 90 Days

  Jian, W.

  11/1/19 → 10/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討家族遺傳性肌萎縮性脊髓側索硬化症的基因突變對胚胎發育的影響及其應用

  Kao, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Neural mechanism of distractor induced attentional orienting and suppression

  Hsu, T.

  12/1/16 → 11/30/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討Homer Scaffolding Protein3 (Homer3)蛋白在乳癌病程進展，治療反應的角色和機制

  Hung, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Pharmacological Investigations of Phenylethanoid Glycosides in Blue Light and N-Retinylidene-N-Retinylethanolamine Induced Retinal Degeneration and Their Protective Effects in Retinopathy

  Cheng, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探究腦指蛋白 ZNF179 (Brain Finger Protein) 的分子機制

  Huang, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Platelet Nano-Scale Vesicles: Delivery Cargo Platform of Neuroregenerative Biomolecules to the Brain( III )

  Burnouf, T. P. R.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Wnt Signals and Programmed Cell Death on the Organization of Neural Circuit in Spinal Motor Neurons

  Kao, T.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dissection of Synergistic Involvement among Different Guidance Families in Spinal Motor Neuron Development

  Kao, T.

  12/1/13 → 11/30/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 整合虛擬實境與穿戴式感測的智慧醫療抗認知衰弱研究

  Chang, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Ihelp: Personalised Health Monitoring And Decision Support Based On Artificial Intelligence And Holistic Health Records

  Shabbir, S. A.

  2/1/22 → 1/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• 伏隔核深腦電刺激術於阿茲海默動物模型的治療潛力

  Lo, Y.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigate the New Therapeutic Strategy of Hinokitiol in Hepatic Ischemia/Reperfusion Injury( I )

  Chen, R.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 高光譜影像於蛋品之食品安全與品質檢測之研究：發展偵測蛋殼表面裂痕、蛋殼品質、微生物污染、生物胺含量、動物用藥及農藥殘留之多重標的檢測技術

  Chuang, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Using Machine Learning to Integrate Multi-Omics Approach in Order to Explore the Potential Biomarkers and Develop Accurate Prediction Model for Post-Stroke Cognitive Impairment

  Hsieh, Y.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology