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Characterization of 5-Hydroxymethylcytosine and Ten-to-Eleven Translocation Gene (TET) in Cervical Cancer

Lai, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Dissected the role of alpha-7 nicotinic receptor in the prognosis and clinical therapy on gastric cancers

Chang, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Immature Testicular Tissue Engineering for Male Fertility Preservation---A Transgenic Mouse Model

Chen, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Molecular mechanisms of propofol-involved protection against ischemia brain injuries

Chen, T.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Reflex Pelvic Floor Muscle Activities in Women with Urinary Incontinence (II)

Yang, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

A translational study to confirm the roles of GATA-DNA BINDING PROTEINS in bone healing

Chen, R.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of CISD2 in the Female Reproductive System of Mammal

Chang, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Studies of Anti-Cancer Activity of Folic Acid

Lee, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Degradation of nitrogen-containing PPCPs: kinetic study, application, and balancing the toxicity of N-DBP and intermediates through bioassay

Chang, E.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

RNA-Seq Analysis of Transcriptome in Toxocara canis L3-Infected Host

Liao, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

探討 GRP78 作為攝護腺癌化學治療之癒後因子之潛能

Chang, Y.

6/1/137/31/14

Project: C - Project of Alliancep - Taipei Medical University Hospital

Study the Therapeutic Effects and Novel Molecular Mechanisms of Resveratrol in Human Osteosarcoma: the Treatment of Metastatic Cancer

Chien, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

A Methodology Study of Integrating Systems Thinking and Bayesian Network in Health Policy

Chuang, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

TMU101-AE1-B65

Wang, T.

8/1/137/31/14

Project: C - Project of Alliancep - Taipei Medical University Hospital

Mechanism and Functional Study of Sumoylation in Mammalian System

Hwang, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Study of Therapeutic Effects for Stroke with Phenserine, an Amyloid Precursor Protein Inhibitor, in Rodent Focal Cerebral Ischemia Model

Chang, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Preparation and Application of New Type Matrix for Aligned Cell Sheet Engineering Use

Tseng, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Investigation of the Effect of Androgen Receptor Knockout on Pathophysiology of Traumatic Brain Injury

Yang, L.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

支援在地老化之智慧生活實驗室規畫(3/3)

Tsai, D.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Design and Development of Antibody-Targetable and Self-Assembled Micelles of Anticancer Drug Conjugate and Complex of Hyaluronic Acid

Sheu, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Indoxyl Sulfate, Chronic Kidney Disease and Heat Shock Protein Modulate the Atrial Electrophysiological Characteristics

Hsieh, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Role of Organic Anion Transporter in Renal Tubular Injury---A Gateway to Hurt

Wu, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Studies on a Thermosensitive Hydrogel of Doxorubicin as Locally Controlled Delivery of Cancer Therapeutics

Ho, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

CAAT/enhancer binding protein beta訊息路徑參與thrombin誘導人類肺部上皮細胞IL-8/CXCL8表現之研究(3/3)

Chen, B.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The influence of Porphyromonas gingivalis GroEL in vascular cells

Lin, F.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

α9-型尼古丁乙醯膽鹼受體在乳癌幹細胞的角色與防治藥物的篩選

Lai, G.

8/1/137/31/14

Project: B - Project of TMUi - Other (Funded by TMU)

The Molecular and Clinical Role of microRNA in Obesity Induced Nephropathy

Lin, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Renoprotective mechanisms of soy protein in rats with diabetic nephropathy 全文電子檔: 全文連結1

Chen, J.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Study on the Preventive Effect and Mechanism of Germinated Brown Rice and Its Components on Colorectal Cancer

Shih, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of glutamine supplementation on T cell homeostasis and inflammatory response in inflammatory bowel disease

Yeh, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Exploring the effects of an exercise program on female diabetic patients$ health

Liao, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Natural Product Hybrid and Ortho-Biaryl N-Hydroxycinnamide as Leads for Anticancer Agent Development

Huang, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Study of Antidepressive and Cognition Improvement Property of N-3 Fatty Acids on Metabolic Syndroms

Huang, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

To Investigate the Functions of Shikonin and Its Derivatives in Applied Age-Related Macular Degeneration and Wound Healining

Cheng, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Role of Sp-family in lung tumorigenesis

Chang, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Antibody-Mediated Immune Suppression of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)

Burnouf, T. P. R.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Sleep and Memory Consilidation in Alzheimer Disease

Hu, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Role of Androgen on Breast Cancer Development and Treatment

Lin, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

大腸直腸癌已躍居世界上癌症死亡率第二名,屬於固體型腫瘤,缺氧常見於此類 腫瘤,並誘發HIF-1α 表現而導致抗藥性及預後較差,因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑,可殺死癌 細胞而不影響正常細胞,對小鼠也不具毒性。我們初步結果顯示,Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現,代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性,對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下,經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制;也有研究報導指出,藥物會誘導癌細胞產生autophagy,造成細胞過度吞噬其內容 物而死亡,因此,autophagy在癌細胞為保護或是引發毒殺作用,目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活,但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示,除抑制HIF-1α 表現外,Zeb 也可活化AMPK、UPR/ER stress、以及autophagy, 因此我們推測Zeb 可在缺氧狀態下,促進autophagic cell death。3 年內我們將執行4 項 目標: (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。(第一年) (2) 研究Zeb 抑制HIF-1α表現之分子機轉。(第一年到第二年) (3) 研究Zeb 誘發autophagy之分子機轉。(第二年到第三年) (4) 探討Zeb 對缺氧導致抗藥性之作用。(第三年)

Yang, P.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Functional Role of Growth Factor-Induced Metabolic Enzymes Expression in Cancer Cell Anti-Oxidation and Drug Resistance

Chang, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Effects of Metabolic Abnormalities on Cognitive Function in Schizophrenic Patients

Lu, M.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology