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• Molecular Mechanisms Underlying Statins-Suppressed Colorectal Cancer Progression: Role of P53 Family Proteins and Microrna

  Hsu, M.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular and Cellular Mechanism of Adipocyte Modulatory Effects on Pulmonary Vein and Atrium

  Chen, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Klf10 Alters Metabolic Pathways in Genetic-Deficient Mice and Human Pancreatic Ductal Carcinomas

  Chang, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Cytoplasmic APe1 in Tumor Malignancy, Drug Resistance and Lung Cancer Prognosis

  Lee, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Study of the Influence on Medical University Students$ Beliefs in Mathematics by Liberal Arts Courses in Mathematics Culture

  Ying, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Roles of Toll-Like Receptor-4 and Hif-1 in Propofol-Involved Protection against Traumatic Brain Injury-Induced Dysfunction of the Blood-Brain Barrier

  Chang, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討鎮靜藥物dexmedetomidine保護腦血管免於缺血-再灌流傷害之機轉: 細胞和動物研究

  Wu, G.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 睡眠困擾是癌症病人最常主訴的問題之一。患有睡眠困擾之癌症病人經常同時伴隨 疲憊、憂鬱等現象發生，形成症狀群集，影響生活品質。雖然目前對於癌症病人睡眠障 礙之量性研究已多有著墨，然而對於癌症病人經歷睡眠障礙之主觀經驗之瞭解，仍相當 有限。瞭解病人經歷睡眠障礙之主觀經驗，將有助於未來睡眠評估工具之修訂。另外， 在評估癌症病人睡眠品質時，若能以簡單工具評估，會更具效率及助益。阿森斯失眠量 表(Athens Insomnia Scale, AIS) 是一個簡單的8 題問卷，廣為使用在一般失眠的病人， 在癌症病人使用上，尚未有豐富的實證資料，若能建立其在癌症病人的信效度，將可作 為一簡單篩檢癌症病人失眠的工具。 睡眠遵行日夜節律規則，日夜節律又需要光作為矯正的線索，光在癌症病人睡眠的 角色，尚未有研究證實，過去研究顯示癌症病人睡眠品質不佳與生物節律有關係。光是 重要日夜節律的線索，光療法透過褪黑激素調節，調整日夜節律週期，可能可以改善睡 眠品質。另外，由於，睡眠障礙、憂鬱、疲憊經常形成一症狀群集，光療法於改善睡眠 障礙之同時，是否亦同時改善憂鬱、疲憊及生活品質。目前，光療法在癌症病人的運用 上，付之闕如，故建立光療法於癌症病人的有效性值得探究。 本研究為三年期研究計畫，目的包括有：1.瞭解癌症個案對於睡眠困擾的主觀經驗 （第一年）。2.建立阿森斯失眠量表中文版的信效度、敏感性、特異性（第一年）。3.瞭 解癌症病人光暴露與生物節率、睡眠障礙的關係（第二年）。4.瞭解光療法對於改善癌 症病人睡眠障礙及相關症狀群集、及生活品質之成效；以及瞭解光療法影響褪黑激素之 程度（第三年）。 本研究擬以癌症住院及門診病人為對象，研究工具包括基本資料、匹茲堡睡眠品質 問卷、阿森斯失眠問卷，簡明疲憊量表，貝克憂鬱量表度、SF-36 生活品質量表、腕動 力器等。資料處理分析方式包括：內容分析、描述性統計、t 檢定、皮爾森相關、GEE (generalized estimating equations)等。 本研究之結果將可瞭解光暴露與生物節率與睡眠障礙之間的關係，並可進一步瞭解 光療法作為改善癌症病人睡眠障礙之護理措施之成效，以期，最終能藉由改善癌症病人 之睡眠品質提昇病人之生活品質。

  Lin, C.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Reflex Pelvic Floor Muscle Activities in Women with Urinary Incontinence (Ii)

  Yang, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of the Involvement of Micrornas in Pressure-Induced Initial Renal Fibrosis

  Chen, T.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies the Function and Mechanism of Dnaja3a/Dnaja3b and Interaction Molecules during the Embryonic Satges

  Chow, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Involvement of Glycosphingolipids and Toll-Like Receptors in Response to Helicobacter Pylori Infection in Gastric Epithelial Cells

  Lin, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cytotoxicity and Application on Drug Resistant Cells of Halide Derivatives of Rutaecarpine

  Lin, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of Sumoylation on Gsk-3beta-Mediated Autophagy

  Shih, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Community-Based Screening and Prevention Model for Periodontal Disease

  Chen, L.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Influences and Underlying Mechanisms of Differentiation and Proliferation in Ox-Ldl and Hdl-Stimulated Human Late-Outgrowth Endothelial Progenitor Cells

  Huang, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Cd69 in Tnfalpha-Inhibited Erythroid Differentiation

  Huang, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Roles of Central Orexin Activities in the Pathophysiology of Hypertension in Shr

  Hwang, L.

  8/1/12 → 9/30/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mechanisms of Apelin in Electrophysiological Characteristics and Calcium Dynamics in Left Atrium and Pulmonary Vein Cardiomyocytes Underlying the Pathophysiology of Atrial Fibrillation

  Chen, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Preparation and Evaluation of Tea Polyphenol Contained Nanocarriers for Ophthalmic Application

  Tseng, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 榖胱甘月太硫轉移酉每參與乳癌致癌之分子機制探討(1/3)

  Wu, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the Immuno-Modulatory Effects of Notch Ligand Delta 4 on Immune Cells and in Ova-Induced Asthmatic Mice

  Lee, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Novel Roles of Arnt in Breast Tumor Progression, Metastasis and Therapy

  Chang, W.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation

  Liang, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Atherosclerosis Progression in Circulating Ferritin in Community-Based Population

  Bai, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluation of the Effects of Selective Serotonin Reuptake Inhibitor on High Grade Glioma

  Shen, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Study on Trans-Neuronal Striato-Nigral Degeneration-Induced Movement Disorders after Stroke: Evaluation with Grey Matter Suppression Ir and Diffusion Tensor Imaging( I )

  Chen, C.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Drug Adherence,Adverse Events,And Impacts on Quality of Life in the Use of Biologic Agents among Patients with Immune-Mediated Inflammatory Diseases

  Tang, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Association between Lipid, Glucose Related Genes and Prognosis of Intra- and Extra-Cranial Stenosis in Stroke Patients

  Chiou, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 包載9α-型尼古丁乙醯膽鹼受體抑制劑之標靶性微脂體劑型設計與開發

  Sheu, M.

  8/1/12 → 7/31/13

  Project: B - Project of TMU › i - Other (Funded by TMU)

• The Roles of Genetic Polymorphisms for Susceptibility and Clinical Outcomes of Colorectal Cancer in Taiwanese Lynch Syndrome Families

  Yeh, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Characterizationof Platelet-Rich Fibrin Releasing Growth Factors and Its Application on Regeneration of Nerve Injury during Radical Prostatectomy

  Ho, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The First Randomized Controlled Clinical Trial for Computerized Decision Support System (II)

  Li, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Roles of Micrornas in Endothelin-1 and Hypoxia-Induced Ctgf Production

  Chen, Y.

  8/1/12 → 7/31/14

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Epigenetic Regulation of Lps-Induced G-Csf Expression in Macrophages

  Chang, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Microrna Let-7g in Cytosolic Ca2+ Regulation and Cox-2 Gene Expression

  Chang, W.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Molecular Mechanisms of a Novel Finger Protein, Znf179, in Neuronal Differentiation

  Lee, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Maternal Depressive Symptomatology on Pregnancy Outcomes and Newborn Development---How Is Paternal Psychopathology Involved?

  Chen, Y.

  8/1/12 → 9/30/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Pulmonary Effects of Chorioamnionitis and Postnatal Hyperoxia in Rat Offspring

  Chen, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Motorcyclist Behavioural Patterns to Pedestrian Green Signal Countdown Device (Pgscd): a Mixed Logit Analysis

  Pai, C.

  8/1/12 → 9/30/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Association Study of Rare Variants and Disease in Case-Parental Data with One of Parents Missing

  Chen, J.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Anti-Αlpha-Enolase I Antibodies on Cancers and Their Potential Applications

  Yang, Y.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Preparation and Modification of Tungsten Oxide Nanomaterials and Its Application as Gas Sensors

  Lin, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Design and Development of Antibody-Targetable and Self-Assembled Micelles of Anticancer Drug Conjugate and Complex of Hyaluronic Acid

  Sheu, M.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Functional Role of Transcription Factor Sp1 in Brain Neuronal Injury( I )

  Chang, W.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Preceptors’ Perceptions of Training Programs and Training Needs, Experienced Barriers during Precepting, and Development and Effectiveness Evaluation of a Preceptor Intervention

  Chang, W.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Novel Development of Continuous Bladder Volume Measurement System

  Chen, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Diffusion Tensor Imaging to Study the White Matter Integrity and Coherence in Resting Electroencephalography

  Hsu, R.

  8/1/12 → 1/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Integration of Research on Novel Antibacterial Mini-Implant

  Lin, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Adlay Hull Extracts on Polycystic Ovary Syndrome (Pcos)

  Hsia, S.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology