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• b - Ministry of Science and Technology

  抗氧化防禦基因標籤單核?酸多形性、氧化壓力生物標記與冠狀動脈心臟病之相關性(1/2)

  Yeh, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Reactive Dicarbonyl Species-Induced Epithelial to Mesenchymal Transition in Diabetes Exacerbating Pulmonary Fibrosis (Ii)－Clarification of Age/Rage-Independent Pathways and Analysis of Correlation with Clinical Outcome

  Hsieh, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Reactive Dicarbonyl Species-Induced Epithelial to Mesenchymal Transition in Diabetes Exacerbating Pulmonary Fibrosis (Ii)－Clarification of Age/Rage-Independent Pathways and Analysis of Correlation with Clinical Outcome(2/2)

  Hsieh, C.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 突觸支架蛋白Shank3調控神經發炎反應在急性缺血性腦中風之病理作用機制研究(2/2)

  Hsieh, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Reflecting on Issues of End-Of-Life by Approaching Ventilator-Dependent Patients: an Interdisciplinary Educational Action Research

  Chen, C., Lin, W., Lin, S. & Tang, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• An Action Research Approach to Clinical Skills Education Development : Using Reflective Writing to Promote the Transformation of Students’ Skill Acquisition toward the Way of Better-Best-Practice

  Lin, W., Chen, C. & Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Investigate the Role of SPNS2 in Determining Individual Susceptibility to Hypoxic Challenge

  Yang, C. H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 麻醉護理專業證照及進階制度之臨床能力架構與評量—客觀結構式臨床測驗(OSCE)與可信賴專業活動(EPA)等工具之建構與驗證研究(1/2)

  Chen, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 應用食品質體學開發食品過敏原(軟體動物)之現場檢測法(2/3)

  Chen, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 食品加工方法、保存條件與肌肉部位對於甲殼類過敏原檢測的影響

  Chen, Y.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Leukemia Based Precision Medicine Research Model on Non-Invasive Apoptosis Detection Platform – Application of Crispr/Cas9 Gene and Target Therapy on Philadelphia Chromosome of Chronic Myelogenous Leukemia as an Example

  Chen, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Explore the Medical Utilization and Quality of Life among Patients with Panic Disorder

  Lin, H.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• DeepNLP-DNA：運用深度編解碼架構及二維卷積神經網路以分析去氧核糖核酸序列表現之預先訓練自然語言處理模型研究(1/2)

  Le, N. Q. K.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討SPNS2對於決定個體缺氧耐受性的影響(3/3)

  Yang, C. H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Investigate the Role of SPNS2 in Determining Individual Susceptibility to Hypoxic Challenge

  Yang, C. H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Impact of Chronic Sleep Deprivation on Neurocognition and Mood Regulation among Adolescents: Focus on Behavioral and Neuroendocrine Alterations in Rodents( I )

  Yang, C. H.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 青少年期慢性睡眠剝奪對認知、情緒與壓力調適功能之影響：動物模式與人類世代之整合研究-青少年期慢性睡眠剝奪對認知與情緒功能之影響：動物模式之行為與神經內分泌功能變化探討(3/3)

  Yang, C. H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 藉由調控神經包網結構來改善早期社交孤立所誘發於模棱兩可的資訊下異常恐懼記憶連結的形成(2/3)

  Yang, C. H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Investigate the Role of Rbm3 in Therapeutic Hypothermia Mediated Neuroprotection in Ischemia Stroke

  Yang, C. H.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigate Pathogenic Role of Rheumatoid Arthritis, Sjogren's Syndrome, Systemic Lupus Erythematosus and Its Combined Syndromes from Post-Translational Modification of Novel Synovial Fluid and Serum Proteins---Study of 4-Hydroxy-2-Nonenal Modificatio

  Lin, C. & Chang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Wearable Wireless Pulse Positioning System to Predict the Prognosis and to Avoid Sudden Death of Dialysis Patients

  Kao, W., Wu, M., Chen, R. & Chen, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of miR-21 in Regulating TET I-Hydroxymethylcytosine and Chemotherapeutic Response in Colorectal Cancer (I)

  Yang, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of SUV39H1 in Control of Inflammatory Genes and in Chronic Inflammation of Copd

  Lee, K., Feng, P. & Chuang, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Immune Alteration and Immunogenic Cell Death in Advanced Non-Small Cell Lung Cancer Patients

  Feng, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 肺癌病人 T 細胞耗竭的調控機制

  Feng, P.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Make a Portable/Wearable Kidney Possible – Development of Microtube Array Membrane (Mtam) Dialyzer – Study on Uremic Toxins Removal

  Wu, M.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Make a Portable/Wearable Kidney Possible – Development of Microtube Array Membrane (Mtam) Dialyzer – Study on Uremic Toxins Removal

  Wu, M.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Make a Portable/Wearable Kidney Possible – Development of Microtube Array Membrane (Mtam) Dialyzer – Study on Uremic Toxins Removal

  Wu, M.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Implantable Artificial Kidney Utilizing Nano-Porous Micro Tube Array Membrane Proof of Concept Study

  Wu, M.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Targeting Hif-1α by Zebularine for the Treatment of Colorectal Cancers

  Yang, P.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Explore the Beneficial Effects of Salubrinal in Bone Loss and Vascular Calcification through Inhibition of Endoplasmic Reticulum Stress and Autophagy in Chronic Kidney Disease-Related Mineral Bone Disorder

  Zheng, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Etelcalcetide經由調控DUSP4和TRAF3路徑於慢性腎臟疾病-礦物質骨病變可改善硫酸??酚引起的低骨轉換率(1/3)

  Zheng, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討非營養性甜味劑對生殖系統之影響及可能作用機轉:從青春期到懷孕期-婦女攝取非營養性甜味劑對懷孕狀況之影響(1/3)

  Hsieh, R.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以量化感覺神經評量(QST)測試下顎齒槽神經受損後感覺恢復與神經修復的關係

  Wu, C.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of Maternal Food Safety-Related Risk Perceptions on Child Actual Mercury Exposure

  Chien, L.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of Maternal Food Safety-Related Risk Perceptions on Child Actual Mercury Exposure

  Chien, L.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 污染場址距離對國小學生重金屬暴露之影響與健康風險評估

  Chien, L.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of an Emergency Medical Capability Ranking Mechanism to Improve the Mass Casualty Distribution System’S Resilience

  Chuang, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Innovation of emergency medical service system to enhance resilience in disaster risk reduction

  Chuang, S.

  1/1/18 → 12/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 開發能獲知機轉的新穎化合物神經毒性預測系統(3/3)

  Tung, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以機器學習和自然語言理解技術探勘社群互動關係及商業智慧之應用(1/2)

  Chang, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 醫病共享決策用於高齡心血管病患之治療選擇初探：病患與醫師觀點

  Hsu, Y.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 政府紓困貸款政策對銀行業的影響：以COVID-19 時期為例

  Hsiao, Y.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Medical Negligence and Patient Safety：How Litigation Facilitates Learning from Mistakes by Healthcare Organizations

  Liang, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 人工智慧醫療浪潮：AI對於臨床藥事服務之影響

  Lee, C.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the Legal System Regarding Development and Application of Ai Healthcare: Constructing Legal Infrastructure of Vi Rtuous Cycle(2/3)

  Lee, C.

  1/1/20 → 12/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• On Risk Governance and Administrative Law: Judicial Review under the Context of National Health Insurance Healthcare Providers Contract as an Example(2/2)

  Liang, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用電子病歷與個人健康資訊建構慢性腎臟病人之紅血球生成刺激劑智慧給藥模型(第二、三年延續案)

  Huang, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects and Molecular Mechanisms of Phthalates (DEHP 和DBP) on the Mitochondrial Function and Genetic Regulation in Ovarian Granulosa Cells and Mouse Embryo(2/2)

  Tzeng, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology