Find Research Projects

Search results

• Finished

  乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

  Wang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Function and Regulation of miRNAs in Pancreatic Cancer Progression (I)

  Huang, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of the APOE4 Allele on Cerebral Structural and Functional Connectivity---A Diffusion Tensor Imaging and Resting-State MRI Study

  Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Regioselective Substitution on 1,4-Benzoquinone Derivatives to Provide Potent Anticancer Agents

  Liou, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating of Transcranial Direct Current Stimulation and Robot-Assisted Gait Training Effects in Subjects with Stroke (II)

  Lai, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Novel Roles of Aldose Reductase (AR) in Collagen GPVI- and Thrombin PAR4-Mediated Platelet Activation and Apoptosis---Regulatory Machinery of Arf-AR Signaling in Anucleate Cells

  Sheu, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Contribution of ER Stress to Inhibit miR-19a/b and miR-26b-Mediated CTGF Expression in Lung Fibrosis (II)

  Chen, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Different Oils Combined with Lycium Barbarum Extract on Chemical-Induced Liver Inflammation and Fibrosis in Rats

  Chao, J. C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of HBX and IL-6 in Regulating SENP1/Stemness Properties of HBV-Related HCC under Hypoxia and Its Clinical Implication

  Huang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cellular and Molecular Mechanisms of Nicotine and Nitrosamines Promote Tumorigenic Behaviors in Renal Cell Carcinoma (II)

  Cheng, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of the Mechanism of HPV Involved Tumorigenesis through Wnt Signaling Pathway Related microRNA Regulation

  Cheng, Y. & Lee, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Clinical Anti-Arthralgia Formulas of Traditional Chinese Medicine to Arthritis

  Wang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 2014馬祖特用植物之開發應用

  Lee, M.

  7/25/14 → 7/30/15

  Project: A - Government Institution › f - Other (Funded by Government)

• 委託辦理103年度「我國壓瘡(pressure sore)發生之影響因子及相關預防策略成效研究」

  Liu, M. F.

  7/13/14 → 11/30/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

• The Empirical Study on Administrative Remedy Cases of National Health Insurance

  Lee, C. & Tsai, F.

  7/8/14 → 1/7/15

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 心血管死因職災個案之風險因子及其保險給付申請比較分析

  Chung, M.

  7/7/14 → 12/20/14

  Project: A - Government Institution › f - Other (Funded by Government)

• TMU102-AE1-B45

  Ho, S.

  7/1/14 → 7/31/15

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• TMU102-AE1-B44

  Liu, Y.

  7/1/14 → 6/30/16

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• TMU102-AE1-B43

  Chen, M.

  7/1/14 → 6/30/16

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• TMU102-AE1-B42

  Lin, Y.

  7/1/14 → 6/30/16

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• 自組裝分子材料之開發及其在光電元件之應用

  Chang, C.

  7/1/14 → 10/31/14

  Project: A - Government Institution › f - Other (Funded by Government)

• The Construction of E-learning Materials for Processing of Chinese Medicine

  Wang, C.

  6/27/14 → 12/15/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 養菇場及蔬菜園勞工生物氣膠暴露及健康影響初探研究

  Chao, H. J.

  6/23/14 → 5/31/15

  Project: A - Government Institution › f - Other (Funded by Government)

• 103年度「食品安全守護聯盟計畫」

  Chen, J.

  6/23/14 → 12/31/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 衛生福利部所屬醫院「103年度滿意度調查評估」採購案

  Kuo, N.

  6/13/14 → 10/15/14

  Project: A - Government Institution › f - Other (Funded by Government)

• 103年至104年職場周全性健康促進模式之發展與成效評估研究計畫

  Chen, R. & Yeh, C.

  6/11/14 → 3/31/15

  Project: A - Government Institution › c - Ministry of Health and Welfare

• The Plan of Customer Protection and Risk Education

  Han, B.

  6/9/14 → 12/31/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 建立癌症新診斷病人健康素養評量工具與評估計畫(103-104年)

  Bai, C. & Yang, K.

  6/4/14 → 6/3/15

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 中高齡就業對長者活躍老化之影響(103-105年)

  Hsu, Y.

  6/4/14 → 9/3/15

  Project: A - Government Institution › c - Ministry of Health and Welfare

• 幼年期睡眠剝奪對骨骼系統發育之影響：褪黑激素治療之潛在成效

  Chang, H.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 探討以特定微型核糖核酸16作為顯影劑引發之腎病變的標的

  Lin, H.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 不同顆粒大小的自體牙齒骨粉對類骨母細胞之影響

  Peng, P.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 探討Nrf2/HSP70/NF-kB 訊息傳導途徑在肺癌幹細胞生成的角色及其抑制劑PES作為抗肺癌幹細胞臨床前研究

  Wu, S.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 新穎可交聯之n 型摻雜有機半導體材料：材料開發、基礎光 電特性分析及其在高效率長壽命太陽能電池之應用

  Chang, C.

  6/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Tetrac於初代大腸癌細胞中強化白藜蘆醇誘導之

  Chang, T.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 具超順磁之奈米四氧化三鐵/聚乳酸可吸收性骨填補材製作與測試

  Huang, H.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 探討黃連素對攝護腺癌細胞對調控上皮細胞與間質細胞轉換之角色與 調控機轉之研究

  Lee, K.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 利用高解析液相串連質譜儀鑑定非小細胞性肺癌腫瘤組織與血漿檢體中多種蛋白水解酶抑制蛋白之轉譯後修飾及其應用於肺癌特異性生物標誌開發之研究

  Lin, J.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 探討EZH2抑制劑UNC1999誘導大腸直腸癌細胞自噬之機轉

  Yang, P.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 利用溫度與時間積分之當量作為量化無線電波射頻造成組織傷害大小範圍之應用

  Hung, S.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 檢測家族性淋巴水腫的致病基因

  Cheng, C.

  6/1/14 → 5/31/16

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 台灣長期接受血液透析之心臟衰竭病人使用β受體阻斷劑之治療效果與存活率分析

  Sue, Y.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 長期空氣污染物暴露與慢性阻塞性肺疾病病患骨質疏鬆症之相關性研究

  Chuang, K.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 鐵質補充對第二型糖尿病的影響

  Chang, J.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 金奈米粒子之口腔癌檢測系統

  Wu, C.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › u - Taipei Medical University Shuang Ho Hospital

• 單碳循環路徑與精神分裂症患者之精神病理學和代謝異常的關係

  Chen, C.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• 口腔與顎顏手術中添加抗生素對硫酸鈣骨移植替代物性質之影響

  Yang, K.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 新穎鋅指蛋白MCPIP1誘導細胞凋亡之分子機制研究

  Liang, Y.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › t - Taipei Municipal Wanfang Hospital

• Calcitriol調控高等糖化終產物受體在糖尿病心臟上的病理生理機轉

  Kao, Y.

  6/1/14 → 5/31/15

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• 開發微米中空纖維陣列膜作為血液過濾器之研究

  Chen, C.

  6/1/14 → 7/31/15

  Project: C - Project of Alliance › p - Taipei Medical University Hospital