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• Etelcalcetide經由調控Nrf2和Klotho-AMPK路徑改善腎性骨病變的骨轉換、血管鈣化和腎臟纖維化

  Zheng, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 研究BTK/HER2信號通路在HER2陽性乳腺癌生物特性角色: 調控T細胞的效應及逆轉賀癌平抗藥性的分子機制(2/3)

  Chao, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新穎癌幹細胞侵犯腳治療標靶之整合性蛋白質體、基因體、小分子與功 能篩選：聚焦細胞表面AMFR於侵犯性消化道癌症治療標的(1/3)

  Tsai, K. K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 標靶B型肝炎誘發之肝癌腫瘤生成與Sorafenib抗藥性之微環境：聚焦發炎激素與癌幹細胞特性之轉譯精準醫學研究與臨床意義-探討微環境發炎細胞激素與基因後生調節於B型肝炎病毒誘導之肝癌表現多能性幹細胞基因OCT4與Sorafenib抗藥性之調控機制與其臨床意義(3/3)

  Huang, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 肺癌病人 T 細胞耗竭的調控機制

  Feng, P.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• TXNIP在肺泡巨噬細胞偏向M1/M2極化中的調控：慢性阻塞性肺病致病機轉的研究(3/3)

  Chen, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 熱休克蛋白在抗藥性髓母細胞瘤及腫瘤幹細胞中的角色

  Chen, S.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 肺纖維化之分子病理機制探討-ADAM17/preadipocyte factor-1在缺氧誘導CTGF表現及呼吸道纖維化角色探討(3/3)

  Chen, B.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 在慢性阻塞性氣喘中double cortin like kinase 1 (DCLK1)在thrombin誘導IL-8/CXCL8表現及氣道發炎的病理角色之研究(1/3)

  Chen, B.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 單側唇?裂患者的鼻道阻塞的評估與治療2(1/2)

  Chen, K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討Homer Scaffolding Protein3 (Homer3)蛋白在乳癌病程進展，治療反應的角色和機制

  Hung, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 腦外傷動物經鼻腔注射FGF-21間質幹細胞之治療效果與機制探究

  Wu, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 奈米HEVnp於晚期大腸直腸癌患者的治療策略(2/3)

  Whang-Peng, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討FCGR3A在肺腺癌中促進癌症惡化的角色和它作為免疫檢查點抑制劑治療效果之預測生物標記的應用

  Zheng, J.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討粒線體因子C20orf7在大腸癌進程中對化療藥物抗藥性及上皮細胞間質轉化作用EMT之調控機轉及大腸癌合併治療策略研究

  Cho, E.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建置與評估可擴充式機器學習演算法之重症醫療資訊平台

  Lo, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 醫學生參與跨國合作融入合作學習之課程發展與評估

  Hsu, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用藥物基因體發展急性登革熱病毒感染期間免疫反應之臨床診斷：探討T細胞組庫和C-型凝集素基因家族之遺傳變異(1/3)

  Chang, W.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• (教學實踐) 系統性強化高齡藥事照護之進階藥學實習評估

  Chang, E. H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › d - Ministry of Education

• The molecular pathogenesis of pulmonary fibrosis-Warburg effect在肺纖維化之角色(3/3)

  Chen, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 助孕酮受器在葉酸抑制腫瘤細胞生長及轉移所扮演的角色(3/3)

  Lee, W.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建構定量系統生理基礎藥動模型以評估腸道菌叢對口服藥物代謝影響及協助奈米膠體處方之開發(1/3)

  Hsieh, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 智能人類血小板顆粒結合多功能聚合物載體做為新型治療的生物醫學平台(2/3)

  Chuang, E.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 評估糖稅課徵政策對肥胖相關疾病負擔之影響：微觀模擬預測模型之研 究(1/2)

  Lo, W.

  8/1/20 → 7/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 開發1,3-二芳基取代之五元雜環作為抗胰臟癌劑(2/3)

  Lee, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 吳茱萸生物鹼rutaecarpine調控血小板活化及自噬作用的機轉探討以及在自體血栓塊引起腦中風鼠的活性評估: NF-kB在無核細胞中的角色(2/3)

  Sheu, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Galectin-1 in Liver Fibrosis-Promoted Stem-Like Cell Properties and Sorafenib-Refractoriness of Hbv-Related Hepatocellular Carcinoma( III )

  Wu, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展三功能抗體(EGFR/CD3/mPEG)修飾之聚乙二醇-免疫增敏奈米藥物以主動標靶毒殺大腸癌並同時強化體內 T 細胞於腫瘤微環境抗癌功效之創新協同療法-發展新型聚乙二醇-免疫增敏奈米藥物載體以毒殺大腸癌並強化腫瘤區域T細胞之抗癌功效(1/3)

  Liu, D.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用長期血液循環腫瘤DNA探討基因變異與前列腺癌復發風險與抗藥性以發展個人化醫療標記之研究

  Shao, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立智慧神經加護病房資料庫(MiNiC)(2/3)

  Lin, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 轉錄因子Sp1在癌細胞抗藥性所扮演角色-花生四烯酸的代謝在Sp1對神經膠質瘤與肺癌抗藥性的陰陽作用中扮演的角色(2/3)

  Chang, W.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抑制NLRP3發炎體- 糖尿病心肌病變的治療新策略

  Lee, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌細胞α9尼古丁受體作為新穎靶向RNA奈米藥物與T細胞療法之臨床轉譯研究-開發抗α9尼古丁受體/抗CD3雙功能抗體以一步驟建構可高效標靶毒殺乳癌腫瘤之武裝型T細胞免疫療法(1/3)

  Chuang, K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Glyoxalase 1 基因控制對肺癌惡性肋膜積水中代謝壓力介導產生的細胞上皮間質轉化與癌轉移的影響機轉(1/3)

  Chung, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 枸杞多醣對鐵沉積及其相關病症之影響

  Wu, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建置公衛研究專用之衛星遙測影像環境資料自動化平台

  Chuang, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 社區民眾血管硬化程度分布，以及血管鈣化硬化粥狀硬化與代謝發炎相關生物標記及其基因多型性關連性研究(3/3)

  Bai, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以參功能抗體或雙功能抗體非共價鍵合至負載 Docetaxel 與 Pictilisib 協同組合量比之聚乙二醇化奈米載體而賦予雙標靶與阻斷功效以用於惡性與轉移性乳癌治療之療效加乘與規避耐藥性(3/3)

  Sheu, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 肺纖維化之分子病理機制探討-IL-21調控的循環纖維球活化參與在慢性阻塞性氣喘之角色(3/3)

  Lin, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 天然物實驗室的自動化設計(3/3)

  Lee, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 遠紅外線改善線粒體功能對糖尿病小鼠胰島β細胞的保護作用及與SIRT1和PLZF相關機制的研究(3/3)

  Chen, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討ARE結合蛋白質與選擇性聚腺甘酸化作用在人類大腸直腸癌上所扮演的角色(3/3)

  Liang, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 噬菌體展現技術製備之辨識蛇毒蛋白的雞源單鏈抗體之分析與人源化研究

  Yang, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討NPC2基因調控肝癌細胞內游離型膽固醇恆定在sorafenib抗藥性之角色(2/3)

  Liao, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌細胞α9尼古丁受體作為新穎靶向RNA奈米藥物與T細胞療法之臨床轉譯 研究-乳癌細胞α9尼古丁受體/HER2複合體作為RNA奈米藥物治療HerceptinR抗藥 性之機制探討(1/3)

  Ho, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 組織胺甲基化轉換酵素(HNMT)輔助臨床醫師鑑別乳癌病患作為Herceptin療效評估之新穎分子標記(2/3)

  Ho, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 基於深度學習與機器學習混合分析多體學數據於癌症精準醫學治療之應用評估(1/2)

  Chang, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Bilateral Parietal-Prefrontal and Glutamatergic Activity in Schizophrenia Patients--Fmri, Rsmri, and Mrs Investigation

  Lane, T. J., Lin, I., Tseng, P. & Lu, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 運用馬桶理論探討腦內代謝物清除：日夜週期對 β類澱粉蛋白質堆積的影響

  Myung, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以隨機對照試驗運用戒菸及中度身體活動代謝當量介入對高齡糖尿病患減緩認知功能障礙成效之探討

  Tsai, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology