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• b - Ministry of Science and Technology

  To Identify Whether Ion Conductance Dysfunction Is an Early Electrophsiological Biomarker of Polyneuropathy in Diabetic Patients: a Longitudinal Study of Nerve Excitability in Diabetic Patients

  Sung, J. & Hu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Systematic Biological Platforms Applying in Endemic Taiwanese Plants

  Lee, M.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Preparation and Application of New Type Matrix for Cell Sheet Engineering Use

  Tseng, H.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• 再生醫學科技發展計畫－全身安全性異體移植策略之細胞治療產品開發:標靶醫療未滿足慢性發炎相關疾病-糖尿病/褥瘡/嚴重燒燙傷之傷口癒合與多發性硬化症(1/3)

  Yen, Y.

  5/1/17 → 4/30/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Neural Mechanism of Distractor Induced Attentional Orienting and Suppression

  Hsu, T.

  12/1/15 → 11/30/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Ultra-Compliant Degradable Hydrogel-Based Bioelectrode Applied for Treating Peripheral Neural Injury

  Huang, W.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Potential Role of Glycogen Synthase Kinase-3 in Dengue Virus-Infected Mononuclear Phagocytes

  Lin, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploratory Study of Self-Identity and Medical Professionalism Among Medical Students

  Chiu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cultivation of Young Scholars: Philosophy of Consciousness

  Lane, T. J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of the Molecular Mechanism Underlying Psat1-Induced Cancer Metastasis

  Lin, Y.

  1/1/16 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

  Wang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dissected the role of alpha-7 nicotinic receptor in the prognosis and clinical therapy on gastric cancers

  Chang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Establish and Evaluate a Rehabilitation Nursing Program for Patients Receiving Orthopaedic Surgery

  Lin, P.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Epigenetic Editing as a Novel Therapeutics for Gynecological Cancer

  Lai, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Functional Peptides Derived from Yam Dioscorin on Anti-aging Activities and Related Mechanisms

  Hou, W.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mechanistic Investigation of Linc00963 on Promoting Lymph Node Metastasis and Drug Resistance through Abcb5 Regulation and Its Potential Theranostic Value during Oral Carcinogenesis

  Tsai, L.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Pathophysiological Role of Microrna in the Development of Emphysema(3/3)

  Su, B.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Sp1-Regulated Neurosteroidogenesis in Glioma Development

  Hsu, T.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 太極對退化性關節炎的高齡者功能性體適能的影響

  Lin, C.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role and Mechanisms of Metabolomics in the Outcome of Acute Ischemic Stroke

  Chi, N.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Assessing the Mechanism and Magnifying the Combined Effects of Exercise and Deep Brain Stimulation for Parkinson'S Disease

  Chen, K.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Ribonucleotide Reductase (Rnr) in Skeletal Muscle with Age: the Functionality of Rrm2b in Repair and Regeneration

  Chen, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Application Study of Personalized Cognitive Training Machine for Older Adults with Mild Cognitive Impairment to Improves Their Memory, Responsiveness, Attention and Coordination

  Chou, K.

  11/1/19 → 10/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Serious games With Interaction That promote Cognitive Health（SWITCH）-探討互動式嚴肅遊戲促進認知健康之成效

  Chiu, H.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 研究慢性阻塞性肺病中調控發炎老化的新機轉: miR-1, miR-133及let-7c之負調控導致過度活化gp130-IL-6信號傳遞路徑(1/3)

  Su, B.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study on the Mechanism of Cross-Talk between Ahr and Autophagy, and Autophagy---Associated Physiological or Pathological Phenomenon on Vascular and Airway Systems (I)

  Li, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 自體免疫心肌炎引起心室心律不整及鈣離子調控失衡、粒線體異常與NLRP3/MIF發炎體訊息路徑活化之致病機轉及治療策略探討(1/3)

  Chen, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 應用人工智慧於評估牙體形態優劣之研究

  Shen, Y.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluation and Management of Symptoms of Fatigue and Sarcopenia in Patients with Liver Cirrhosis

  Huang, H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 脂肪激素內脂素對子宮肌瘤增生及微環境影響:分子機制探討及精準營養應用之研究(2/3)

  Hsia, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Transforming growth factor beta引發呼吸道過度敏感：肺迷走C纖維感覺神經的角色(3/3)

  Hsu, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploiting Acridine Scaffold to Develop Novel Anticancer Agents Based on a Dual Target Strategy

  Huang, W.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Wnt Signals and Programmed Cell Death on the Organization of Neural Circuit in Spinal Motor Neurons

  Kao, T.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 認知行為教育與運動介入對冠狀動脈心臟病患者戒菸和 身心健康成效之探討: 跨理論模式之應用(2/2)

  Jeng, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Epigenetic Targeting for Potential Tumor Suppressor Genes, Poldip2 and Sox1, with Investigations of Prognostic and Therapeutic Implications in Non-Small Cell Lung Cancer

  Tzao, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Establishment and Evaluation of Light Intervention Model for Patients with Schizophrenia

  Chung, M.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 粒腺體亞甲基四氫葉酸脫氫酶(MTHFD2)對於口腔癌癌幹細胞特性及腫瘤生成之影響及機制探討

  Chiang, P.

  3/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Lay Health Knowledge Research:Example of Infants and Children Dietary Supplement

  Chen, Y. C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the anti-islet hypertrophy and anti-osteoporosis constituents from Formosan Fern

  Hsu, F.

  8/1/13 → 12/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Nano-Diamino-Tetrac (Ndat) Enhances Resveratrol-Induced Anti-Proliferation by Action on the Rrm2 Pathway in Colorectal Cancers

  Lin, H.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Jet Lag as a Potent Manipulator of Mood(1/2)

  Myung, J.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Chromatin Remodeling and Akt-Dependnet mTOR/S6K Mediate Thrombin-Induced IL-8/CXCL8 in Lung Epithelial Cells

  Chen, B.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Epigenetic Regulation of Lps-Induced G-Csf Expression in Macrophages

  Chang, S.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Development and Preclinical Evaluation of a Theronostic Nanovehicle Drug for Treating Acute Myeloid Leukemia and Leukemia Stem Cells.( II )

  Yen, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Genetic Polymorphisms on Efficacy and Safety of Opioid Analgesics in Patients with Postoperative Pain in a Taiwanese Population

  Tai, Y.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Neuroprotective Effects of Sig-1r-Znf179-Sp1 Pathway on Brain Injury

  Chang, W.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探究腦指蛋白 ZNF179 (Brain Finger Protein) 的分子機制

  Huang, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cell Behaviors and Its Gene Analysis of Nerve-Like Cell on Three-Dimensional Fibrous Matrix

  Tseng, H. & Ho, Y.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Pharmacological Investigations of Phenylethanoid Glycosides in Blue Light and N-Retinylidene-N-Retinylethanolamine Induced Retinal Degeneration and Their Protective Effects in Retinopathy

  Cheng, Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of Content of Identity and Identification--The Interplay of Individual and Organizational Level

  Chiu, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology