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• b - Ministry of Science and Technology

  癌症代謝重整對肥胖相關乳癌之分子調控與轉譯價值

  Lin, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 肺阻塞表型分析與治療策略(2/3)

  Tseng, C.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Chitosan Nanopolyplex Mediated Delivery of Anti-Fibrotic Mirna for the Treatment of Oral Submucous Fibrosis (1/3)

  Yang, K.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of fish oil on alcoholic liver disease in rats based on pathological mechanisms

  Yang, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建構定量系統生理基礎藥動模型以評估腸道菌叢對口服藥物代謝影響及協助奈米膠體處方之開發(3/3)

  Hsieh, C.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Study of the Trismus Condition of Patients with Head and Neck Cancer Who Have Undergone Concomitant Chemoradiotherapy and the Preventive Effect of Oral Rehabilitation on Trismus

  Jeng, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 不同脂肪酸組成的植物油對停經後肌肉萎縮之影響-以肌腸軸、胰島素阻抗及粒線體功能觀點進行探討

  Chiu, W.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Home-Based Exercise Training on Fatigue, Sleep Disturbance, Symptom Distress and Quality of Life in End-Stage Renal Disease Patients(3/3)

  Lin, C.

  8/1/16 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討以機器模擬胚胎心跳脈動性的敲擊震動對傷口癒合過程中血管新生之影響

  Fong, T.

  7/1/22 → 2/28/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• 金屬細懸浮微粒在慢性阻塞性肺病的第二型肺泡上皮細胞Yap/Taz調控衰老機轉之研究(1/3)

  Chuang, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• miRNA作為中風後血管性認知障礙生物標記相關性之研究

  Chiou, H.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討小泛素蛋白酶Sentrin-specific protease 2 參與轉型生長因子-beta訊息傳遞的作用機制(1/2)

  Chang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Neuroendocrine-Immune Mechanisms of Physical Activity on Behavioral Symptoms in Lung Cancer Patients---A Comparison of Patients Receiving Active Treatments and Survivors

  Lin, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Phosphoproteome Analysis of Sperm during Capacitation and Modulations of Chinese Medicines

  Wu, T.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Combine anesthesia information system with artificial neural networks to develop the surgical complication pre-warning system

  Lin, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討粒線體因子C20orf7在大腸癌進程中對化療藥物抗藥性及上皮細胞間質轉化作用EMT之調控機轉及大腸癌合併治療策略研究

  Cho, E.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development and Characterization of Zein-Sodium Caseinate Nanoparticles-Hydrogel Composite for Localized and Sustained Sirna Delivery

  Hsieh, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討HDAC/LSD1雙效抑制劑對KRAS突變及 5-FU抗藥性大腸癌細胞之治療及機轉研究

  Cho, E.

  7/1/22 → 2/28/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of the Intestinal Health-Improvement Factors on Leaky Gut Syndrome, Gut Microbiota Diversity and Sarcopenia in Rats with Alcoholic Liver Diseases Based on Gut-Liver-Muscle Axis

  Yang, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Therapeutic Potential of Regulation of Prostaglandin E2 Receptor and Autophagy by Endothelin-Converting Enzyme Inhibition in Chronic Kidney Disease( III )

  Chiu, H.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Series of Studies Analyzing Exercise Behavior and Exploring the Effects of Interventions among Pre-Diabetes, Type 1, and Type 2 Diabetes

  Jeng, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Neuroendocrine-Immune Mechanisms of Physical Activity on Behavioral Symptoms in Lung Cancer Patients---A Comparison of Patients Receiving Active Treatments and Survivors

  Lin, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 睡眠困擾是癌症病人最常主訴的問題之一。患有睡眠困擾之癌症病人經常同時伴隨 疲憊、憂鬱等現象發生，形成症狀群集，影響生活品質。雖然目前對於癌症病人睡眠障 礙之量性研究已多有著墨，然而對於癌症病人經歷睡眠障礙之主觀經驗之瞭解，仍相當 有限。瞭解病人經歷睡眠障礙之主觀經驗，將有助於未來睡眠評估工具之修訂。另外， 在評估癌症病人睡眠品質時，若能以簡單工具評估，會更具效率及助益。阿森斯失眠量 表(Athens Insomnia Scale, AIS) 是一個簡單的8 題問卷，廣為使用在一般失眠的病人， 在癌症病人使用上，尚未有豐富的實證資料，若能建立其在癌症病人的信效度，將可作 為一簡單篩檢癌症病人失眠的工具。 睡眠遵行日夜節律規則，日夜節律又需要光作為矯正的線索，光在癌症病人睡眠的 角色，尚未有研究證實，過去研究顯示癌症病人睡眠品質不佳與生物節律有關係。光是 重要日夜節律的線索，光療法透過褪黑激素調節，調整日夜節律週期，可能可以改善睡 眠品質。另外，由於，睡眠障礙、憂鬱、疲憊經常形成一症狀群集，光療法於改善睡眠 障礙之同時，是否亦同時改善憂鬱、疲憊及生活品質。目前，光療法在癌症病人的運用 上，付之闕如，故建立光療法於癌症病人的有效性值得探究。 本研究為三年期研究計畫，目的包括有：1.瞭解癌症個案對於睡眠困擾的主觀經驗 （第一年）。2.建立阿森斯失眠量表中文版的信效度、敏感性、特異性（第一年）。3.瞭 解癌症病人光暴露與生物節率、睡眠障礙的關係（第二年）。4.瞭解光療法對於改善癌 症病人睡眠障礙及相關症狀群集、及生活品質之成效；以及瞭解光療法影響褪黑激素之 程度（第三年）。 本研究擬以癌症住院及門診病人為對象，研究工具包括基本資料、匹茲堡睡眠品質 問卷、阿森斯失眠問卷，簡明疲憊量表，貝克憂鬱量表度、SF-36 生活品質量表、腕動 力器等。資料處理分析方式包括：內容分析、描述性統計、t 檢定、皮爾森相關、GEE (generalized estimating equations)等。 本研究之結果將可瞭解光暴露與生物節率與睡眠障礙之間的關係，並可進一步瞭解 光療法作為改善癌症病人睡眠障礙之護理措施之成效，以期，最終能藉由改善癌症病人 之睡眠品質提昇病人之生活品質。

  Lin, C.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• New Strategies of Parkinson’s Disease Treatment

  Chiang, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Molecular Biological Mechanism of Fish Oil on Preventing Alcoholic Liver Diseases: The Hepatoprotective Effects of EPA and DHA Based on Lipid Metabolism, Autophagy and Inflammatory Responses

  Yang, S.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Food Safety: the Interrelationships among Trust, Risk Perception, Mother'S Health Behavior and Child Development(II)(1/2)

  Chuang, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展以同步量測中樞與周邊系統功能性訊息為導向之年長跌倒患者步態復健評估(3/3)

  Chan, W. P.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Mechanism of Action and Clinical Significance of a Newly Discovered Protein Phosphatase 1 Regulatory Subunit, Pp1r15b, in Drug Tolerant Persister Glioma Cells

  Yeh, C.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Regular Exercise on Emotional Control and Cognitive Function of Prefrontal-Limbic Pathway in Sleep-Deprived Rats---An Analysis by Behavior and Neurostructural Correlates

  Hsu, C. & Chang, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Development and Clinical Application of a Miniature Transcranial Direct Current Stimulator in Rehabilitation Therapy (II)

  Peng, C.

  11/1/14 → 6/30/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Rich Platelets Plasma and Alginate Encapsulated Synovial Fluid Mesenchymal Stem Cells for Repairing the Partial Tear of Cruciate Ligament

  Chen, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Development and Clinical Application of a Miniature Transcranial Direct Current Stimulator in Rehabilitation Therapy

  Peng, C.

  11/1/13 → 10/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Large Series of Clinical and Imaging Investigation to Patients with Chronic Lower Limb Edema with Unclear Etiology

  Chan, W. P.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Study the Role of Multidrug Resistance Protein 4 on Induction of Aspirin Resistance in Type 2 Diabetes Mellitus

  Lu, W.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Association between Lipid, Glucose Related Genes and Prognosis of Intra- and Extra-Cranial Stenosis in Stroke Patients

  Chiou, H.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of the Combination of Decelluarized Extracellular Matrix Grafted by Graphene and Bone Marrow Aspirate Concentrates on the Healing of Partial Tear of Anterior Cruciate Ligament(3/3)

  Chen, C.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Combine Anesthesia Information System with Artificial Neural Networks to Develop the Surgical Complication Pre-Warning System

  Lin, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The effects on mental health, stress, and physical activity from the urban natural environment: A comparison between real and virtual experiences(1/3)

  Yen, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Endoplasmic Reticulum Stress Response and Autophagy in Chronic Kidney Disease by Nanoparticle Drug Delivery System

  Lin, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 台灣家族特有肌聯蛋白單酶酸位點變異導致肌失養症之病因學研究

  Kuo, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Pathogenic Role of Ifn-Alpha in a Spontaneous Hashimoto'S Thyroiditis Mouse Model

  Lin, J.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Combination Treatment of Tetrac- and Cetuximab-Induced Anti-Proliferation in Colorectal Cancer with Different Apc Status( III )

  Lin, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Cognitive-Behavioral Education and Exercise Interventions on Smoking Cessation and Physical and Mental Health in Patients with Coronary Heart Disease: Application of the Transtheoretical Model(1/2)

  Jeng, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Normoxic Expression of Hypoxia Inducible Factor 1-Α and Endoplasmic Reticulum Stress Associated Protein Grp-78 in the Modulation of Drug-And Radioresistance Acquisition of Human Hepatoma Cell Lines

  Chiou, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抗氧化防禦基因標籤單核?酸多形性、氧化壓力生物標記與冠狀動脈心臟病之相關性(1/2)

  Yeh, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 瘦體素胜?衍生物OB3抑制瘦體素誘導的原發性肝細胞癌細胞增生之研究

  Yang, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Tumor Microenvironment Induced Egfr-Tki Resistance

  Feng, P.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展一套數位化之老人跌倒風險評估篩檢工具

  Peng, C.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 健康教練介入對改善第二型糖尿病人之健康行為、糖尿病情緒困擾及血糖控制之隨機對照試驗(2/2)

  Yang, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 生物活性鈣鈉磷矽酸鹽交聯明膠-奈米氧化石墨烯水膠在非承力骨組織工程的應用

  Chen, C.

  7/1/22 → 2/28/23

  Project: A - Government Institution › b - Ministry of Science and Technology