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• b - Ministry of Science and Technology

  Study on the Immuno-Modulatory Effects of Notch Ligand Delta 4 on Immune Cells and in Ova-Induced Asthmatic Mice

  Lee, Y., Leu, S. & Liu, H.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Dendritic Cells 100%
  • Ligands 43%
  • Asthma 39%
  • STAT4 Transcription Factor 34%
  • Th2 Cells 23%

• CHRNA7-p38MAPKs axis發炎基因網絡在巨噬細胞極化作用及對脂蛋白(a)引發冠狀動脈細胞痙攣的機制探討(2/3)

  Hung, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 紅藜殼萃取物對誘發鐵轉運蛋白及抑制胰臟癌細胞生長

  Chiu, C.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 從食安風險暴露之角度探討非營養性甜味劑對女性生殖狀況之影響-非營養性甜味劑在妊娠期糖尿病發生所扮演的角色(1/3)

  Wu, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Repurposing of a Positive Allosteric Modulator of M5 Muscarinic Acetylcholine Receptor as a Microtubule-Targeting Agent and Its Application for Treating Pancreatic Ductal Adenocarcinoma

  Hsieh, Y.

  1/1/19 → 6/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Deciphering the Molecular Regulatory Mechanisms of Ccl20-Ccr6 Chemokine Cascade in Epithelial-Mesenchymal Transition and Chemo-Resistance in Colon Cancer, and Also the Strategy for Cancer Treatment

  Cho, E.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Autolysin regulatory machinery of Streptococcus mutans in bacterial survival and biofilm formation in infective endocarditis

  Jung, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Endocarditis 100%
  • Streptococcus mutans 24%
  • Ions 22%
  • N-Acetylmuramoyl-L-alanine Amidase 20%
  • Biofilms 20%

• Application of Multi-Omic Approaches to Evaluate the Effects of the Exercise on Exercise Performance, Metabolism and Neuropsychological Function of Long-Term or Acute Sleep Deprivation(1/3)

  Tung, Y.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Exploring Gene-Lifestyle Factors of Childhood Obesity, Pubertal Development, and Insulin Resistance

  Chen, Y.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• BSP相似重複序列家族蛋白在草綠色鏈球菌所引起的感染性心內膜炎中細菌逃避免疫攻擊及生物膜形成所扮演的角色及機制探討(2/3)

  Jung, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Innate Immune Modulator: Molecular Characterization of Bupleurum kaoi Polysaccharide Fraction and Assessment of its Immunomodulatory and Antiviral Effects

  Lin, L. T.

  11/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Polysaccharides 100%
  • Antiviral Agents 81%
  • Bupleurum 79%
  • Innate Immunity 32%
  • Hepacivirus 21%

• Kidney Injury and Heat Shock Protein Modulate the Atrial Electrophysiological Characterisitcs

  Hsieh, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chronic Renal Insufficiency 100%
  • Atrial Fibrillation 87%
  • Heat-Shock Proteins 68%
  • Indican 66%
  • Neomycin 41%

• 台灣老年失智症人口之用藥分析：利用全民健康保險資料庫研究失智症患者使用抗膽鹼藥物之情況與誘發潛在疾病之風險

  Wu, C.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討粒線體因子C20orf7在大腸癌進程中對化療藥物抗藥性及上皮細胞間質轉化作用EMT之調控機轉及大腸癌合併治療策略研究

  Cho, E.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Chemo-Sensitizer Conjugated Carbon Nanotubes as a Novel Cancer Therapeutical Delivery System

  Cho, E.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Carbon Nanotube 100%
  • Radiation Sensitizing Agent 38%
  • Ribonucleotide 28%
  • Water Soluble 17%
  • Drug 12%

• The Influence of Porphyromonas Gingivalis Groel in Vascular Cells

  Lin, F.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Porphyromonas gingivalis 100%
  • blood vessels 46%
  • myocytes 40%
  • smooth muscle 39%
  • atherosclerosis 36%

• The Effects of Lipoprotein on the Endothelial-To-Mesenchymal Transition Process of Mature Endothelial Cell and Endothelial Progenitor Cells in Vessel Neo-Intimal Formation

  Huang, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • erucylphosphocholine 100%
  • HDL Lipoproteins 96%
  • oxidized low density lipoprotein 25%
  • Dyslipidemias 16%
  • Atherosclerosis 13%

• Analysis of International Classification of Functioning, Disability and Health (Icf) to Predict Return to Work among Young Stroke Patients

  Liou, T.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • stroke 100%
  • social participation 26%
  • International Classification 20%
  • social support 19%
  • disability 16%

• Investigation on the Potentials of Water Extracts Obtains from Ganoderma Lucidum Fruit Body for Inhibition of Colorectal Cancer (Crc) Mediated by Regulating Gut Microbiota

  Tai, C.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • colorectal neoplasms 100%
  • intestinal microorganisms 54%
  • neoplasms 41%
  • Ganoderma lucidum 36%
  • neoplasm progression 20%

• Phosphodiesterase Isoforms Inhibitors on Atrial Arrhythmogenesis from Modulations on Fibroblasts Activity and Cardiomyocytes Electrophysiology

  Huang, J.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluating the Role of Fibrinolytic Proteins on Insulin Secretion and Regeneration of Islet Cells in Obesity and Type 2 Diabetes during Exercise

  Wu, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Plasminogen Activators 100%
  • Urokinase-Type Plasminogen Activator 96%
  • Type 2 Diabetes Mellitus 74%
  • Insulin Secretion 56%
  • Exercise 55%

• Research of Carbon Nanomaterials Conjugated with Raf Kinase Inhibitors as Multifunctional Delivery System for Kras Mutated Colorectal Cancer Treatment

  Cho, E.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Nanomaterial 100%
  • Phosphotransferase Inhibitor 75%
  • Carbon Atom 74%
  • Drug 63%
  • Folic Acid 23%

• To Study the Effects and Underlying Mechanisms of B Type Natriuretic Peptide in Endothelial-Mesenchymal Transition: a Study Regarding to Cardiac Allograft Vasculopathy

  Lin, F.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Brain Natriuretic Peptide 100%
  • Thrombomodulin 99%
  • Endothelial Progenitor Cells 55%
  • Allografts 52%
  • Tissue Donors 47%

• Catalpol Acts as an Immunomodulator on Immune Cells and Exerts Anti-Allergic Effects on Ovalbumin-Induced Allergic Diseases in Mice

  Lee, Y.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • catalpol 100%
  • Mast Cells 16%
  • Asthma 15%
  • Immunoglobulin E 15%
  • Dendritic Cells 12%

• Application of Proteomic and Metabolomic Approaches to Discovery the Biomarkers for the High Fat Diet-Induced Atherosclerosis and Brain Stroke in Apoe Gene Knockout Mice

  Tung, Y.

  12/1/17 → 11/30/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Adaptive Evolution of Pseudomonas Aeruginosa Within Hosts

  Huang, T.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Pseudomonas aeruginosa 100%
  • Cystic Fibrosis 70%
  • Pseudomonas Infections 44%
  • Whole Genome Sequencing 41%
  • Hospitalization 39%

• 時差對於大腦上視神經交叉核的丙胺基丁酸神經元網路結構之研究(2/2)

  Myung, J.

  3/1/19 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dysmetabolic Iron Overload Syndrome and Testosterone Biosynthesis: Role of Fat and Iron Enriched Diet(2/3)

  Chang, J.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 嗜伊紅性白血球陽離子蛋白衍生之細胞穿透胜肽對於調節過敏性發炎之研究- 促進STAT-6反義RNA之運送與表現(2/3)

  Lee, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of Lipoprotein on the Endothelial-To-Mesenchymal Transition Process and Vessel Neo-Intimal Formation (Continuation of Most 106-2314-B-038-081; 2/3 & 3/3)

  Huang, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Endothelial Progenitor Cells 100%
  • Lipoproteins 44%
  • Endothelium 20%
  • Cardiac Catheters 16%
  • Observation 16%

• Characterization of DnaJA3 Interaction Proteins Function during the Developmental Stage of Zebrafish

  Chou, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Zebrafish 100%
  • Morphogenesis 98%
  • Wnt Signaling Pathway 74%
  • Embryonic Development 60%
  • Apoptosis 39%

• The Influence of Porphyromonas gingivalis Groel in Vascular Cells

  Lin, F.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Porphyromonas gingivalis 100%
  • blood vessels 46%
  • myocytes 40%
  • smooth muscle 39%
  • atherosclerosis 36%

• Studies the Function and Mechanism of Dnaja3a/Dnaja3b and Interaction Molecules during the Embryonic Satges

  Chow, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Zebrafish 100%
  • Embryonic Development 60%
  • Embryonic Structures 53%
  • Apoptosis 39%
  • Protein Folding 38%

• Oncolytic Measles Virus for the Treatment of Breast Adenocarcinoma

  Lin, L. T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Measles virus 100%
  • Breast Neoplasms 37%
  • Adenocarcinoma 25%
  • Reverse Genetics 17%
  • Breast 14%

• Development of Antibody Targeting Alpha-Enolase of Candida Albicans and Their Potential Applications

  Leu, S.

  6/1/19 → 5/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Immunomodulatory Role of Melatonin in Promoting the Progression of Graves' Disease

  Lin, J.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • melatonin 100%
  • thyrotropin receptors 35%
  • thyroid diseases 25%
  • hyperthyroidism 14%
  • autoimmune diseases 13%

• 胃腸科相關癌症之差異蛋白質體與致病機轉之研究

  Lee, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 產學合作計畫－抗藥性白色念珠菌單鏈抗體之研發

  Leu, S.

  11/1/20 → 10/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Jet lag, based on GABAergic network structure of the SCN (1/2)

  Myung, J.

  3/1/18 → 2/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Recovery 100%
  • Sleep 39%
  • Clocks 31%
  • Modulation 28%
  • Neural networks 22%

• Effects of Cafestol on Cardiac Hypertrophy.

  Liu, J.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Multi-Omic Approaches to Evaluate the Effects of the Exercise on Exercise Performance, Metabolism and Neuropsychological Function of Long-Term or Acute Sleep Deprivation(2/3)

  Tung, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Targeting Novel D2r Heteroreceptor Complexes as Anti-Dengue Strategy by Interfering Viral Infection and Immunopathogenesis

  Lin, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 住院急性胰臟炎使用鴉片類處方藥物病人之持續性使用分析

  Chen, S. H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討趨化因子CCR6於大腸癌5-FU抗藥性的調控機轉及合併治療研究

  Cho, E.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抗發炎藥物與生物製劑藥物對類風濕性關節炎病人發生惡性腫瘤之影響：健保資料庫分析研究

  Chen, S. H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Tumor Necrosis Factor Inhibitors 100%
  • National Health Programs 86%
  • Drug-Related Side Effects and Adverse Reactions 76%
  • Pharmaceutical Preparations 56%
  • Rheumatoid Arthritis 45%

• Liver Kinase B1 Dictates Glutamine Addiction and Gemcitabine Response in Pancreatic Ductal Adenocarcinoma

  Chiu, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Disturbances of One Carbon Metabolism and Gsk3β Signaling in Depressive Conditions and Effects of Tribulus Terrestris Fruits

  Wu, T.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluating the Long-Term Effect of Low-Dose Aspirin Use during Pregnancy on the Prevention of Cardiovascular Disease among Women after Delivery

  Wu, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 台灣肝硬化病人使用抗膽鹼藥物與發生肝性腦病變之風險評估(1/3)

  Wu, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Impact of Angiogenic Growth Factors on Inflammation and Microvasculature in Renal Fibrosis

  Chang, F.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology