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  睡眠困擾是癌症病人最常主訴的問題之一。患有睡眠困擾之癌症病人經常同時伴隨 疲憊、憂鬱等現象發生，形成症狀群集，影響生活品質。雖然目前對於癌症病人睡眠障 礙之量性研究已多有著墨，然而對於癌症病人經歷睡眠障礙之主觀經驗之瞭解，仍相當 有限。瞭解病人經歷睡眠障礙之主觀經驗，將有助於未來睡眠評估工具之修訂。另外， 在評估癌症病人睡眠品質時，若能以簡單工具評估，會更具效率及助益。阿森斯失眠量 表(Athens Insomnia Scale, AIS) 是一個簡單的8 題問卷，廣為使用在一般失眠的病人， 在癌症病人使用上，尚未有豐富的實證資料，若能建立其在癌症病人的信效度，將可作 為一簡單篩檢癌症病人失眠的工具。 睡眠遵行日夜節律規則，日夜節律又需要光作為矯正的線索，光在癌症病人睡眠的 角色，尚未有研究證實，過去研究顯示癌症病人睡眠品質不佳與生物節律有關係。光是 重要日夜節律的線索，光療法透過褪黑激素調節，調整日夜節律週期，可能可以改善睡 眠品質。另外，由於，睡眠障礙、憂鬱、疲憊經常形成一症狀群集，光療法於改善睡眠 障礙之同時，是否亦同時改善憂鬱、疲憊及生活品質。目前，光療法在癌症病人的運用 上，付之闕如，故建立光療法於癌症病人的有效性值得探究。 本研究為三年期研究計畫，目的包括有：1.瞭解癌症個案對於睡眠困擾的主觀經驗 （第一年）。2.建立阿森斯失眠量表中文版的信效度、敏感性、特異性（第一年）。3.瞭 解癌症病人光暴露與生物節率、睡眠障礙的關係（第二年）。4.瞭解光療法對於改善癌 症病人睡眠障礙及相關症狀群集、及生活品質之成效；以及瞭解光療法影響褪黑激素之 程度（第三年）。 本研究擬以癌症住院及門診病人為對象，研究工具包括基本資料、匹茲堡睡眠品質 問卷、阿森斯失眠問卷，簡明疲憊量表，貝克憂鬱量表度、SF-36 生活品質量表、腕動 力器等。資料處理分析方式包括：內容分析、描述性統計、t 檢定、皮爾森相關、GEE (generalized estimating equations)等。 本研究之結果將可瞭解光暴露與生物節率與睡眠障礙之間的關係，並可進一步瞭解 光療法作為改善癌症病人睡眠障礙之護理措施之成效，以期，最終能藉由改善癌症病人 之睡眠品質提昇病人之生活品質。

  Lin, C.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• LC/MS/MS Technique and Its Application Analysis of Natural Products

  Lee, C.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Molecular Ivestigation of the Electron Transfer Flavoprotein Dehydrogenase Mutation Induced Mitochondrial Dysfunction and Metabolic Defects

  Kao, S. & Hsu, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用機器學習模型預測耐甲氧西林金黃色葡萄球菌血流感染病人使用萬古黴素和太古盤寧素之腎毒性風險

  Chen, S. H.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 基於深度學習與機器學習混合分析多體學數據於癌症精準醫學治療之應用評估(2/2)

  Chang, T.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以社交溝通障礙相關的神經影像基礎開發泛自閉症症候群幼兒早期輔助診斷影像標誌與療育成效影像預測指標

  Lo, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Legal Reform for Improving Vaccine Procurement and Preparedness Framework in Taiwan

  Ho, J.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Structural and Functional Studies on the Virulence Regulators SaeR/S in Staphylococcus aureus

  Liu, C.

  12/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• LC-MS-MS Technique and Its Application Analysis of Natural Products

  Lee, C.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Reactions of NSAIDs (Mefenamic Acid and Diclofenac) by O3/GAC Processes---Intermediates, Pathway and Kinetic Models

  Chang, E.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Utilizing Artificial Intelligence Vi Rtual Screening Platform to Identify a Small-Molecule Inhibitor of Dna Polymerase Theta and Estimating Its Therapeutic Effectiveness on Metastatic Castration-Resistant Prostate Cancer

  Lin, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立一套二階段快速DNA突變分析用於家族性高膽固醇血症

  Chiou, K.

  8/1/17 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討急性肺損傷之精準幹細胞治療策略與臨床應用: 肺部微環境修復之分子與細胞圖譜及其作用機制-臨床級胎盤間葉幹細胞對急性肺損傷/急性呼吸窘迫症後肺纖維化治療效果的轉譯研究(1/3)

  Wu, M.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 研究細胞外基質膠原蛋白誘發的酸性微環境促進惡性膀胱腫瘤之角色功能探討(1/2)

  Lee, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Comparing the Inflammatory and Immunopathological Change of Brain in Hosts with Angiostrongylus Cantonensis Infection by Using nanoPET Imaging Technique

  Cheng, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Targeting Metabolic Addiction of Prostate Cancer(2/3)

  Kung, H.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 運用重心量測技術之病人離床監控系統開發

  Chen, H.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立新興環境汙染物與藥物毒理預測平台之研究

  Hsu, K.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌細胞α9尼古丁受體作為新穎靶向RNA奈米藥物與T細胞療法之臨床轉譯研究-探討α9尼古丁受體基因表現在乳癌病人血液循環腫瘤細胞/游離DNA於乳癌治療的應用(2/3)

  Tzeng, H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 子宮內膜異位症體外血清診斷試劑開發計畫(2/2)

  Yang, W.

  4/1/16 → 1/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 闡明CEEMT(環境豐富化合併音樂療法) 對腦外傷後認知、憂鬱與焦慮的影響與機制探討

  Chen, K.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Mutiple Pharmceuticals Adsorption, Oxidation and Catalytic Chlorination by Metal Oxides ( II )

  Hu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Impact of Environmental Change on Spatial and Temporal Variations of Dengue Outbreaks---Toward Dengue Early Warning System

  Chuang, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Manipulating Neural Oscillations in Frequency and Phase Shifting Using Transcranial Alternating Current Stimulation: An Investigation into the Oscillatory Neural Mechanisms of Visual Working Memory(2/3)

  Tseng, P.

  12/1/16 → 11/30/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Cultural and Legal Factors in the Religious Disputes during the Late Imperial China and the Early Republican Period: a Weberian Comparative Sociology of Missionary Case, Temple Destruction and Confiscation Campaigns, and Confucian Church Movement

  Tsai, P.

  12/1/15 → 11/30/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Predict the Recurrence of Major Depressive Disorder Within an Integrated Bio-Psycho-Social Framework---A Follow-up Study

  Lee, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Manipulating Neural Oscillations in Frequency and Phase Shifting Using Transcranial Alternating Current Stimulation: an Investigation into the Oscillatory Neural Mechanisms of Visual Working Memory

  Tseng, P.

  12/1/17 → 11/30/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Research and Development Plans of Embodied Medical Humanity Education（The Ground）： Educational Action Research of the Curriculum Design of Somatic Learning toward the Clinical Situation

  Lin, W.

  8/1/18 → 1/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Taiwanese Women’S Situatedness of Being Either Single, Childless or Pregnant in Advanced Maternal Age

  Shih, L.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Neural and Glutamatergic Correlates of Resting State Activity and Stimulus-Induced Activity in Major Depressive Disorder---Can Multimodal Imaging (fMRI and MRS) Reveal Therapeutic Predictors?

  Chen, C., Lane, T. J., Hu, C., Tseng, Y. & Lee, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Enacting Pregnant Women, Enacting the Foetus Prenatal Screening and Testing in Taiwan

  Shih, L.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Differentiation of Literati-Gentry Strata and the Construction of Citizenship in the Late Qing Dynasty and the Early Republican Period: a Cultural Pragmatics Approach

  Tsai, P.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Promise of Prenatal Genetic Screening and Testing: Noninvasive Prenatal Diagnosis in Taiwan

  Shih, L.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Honesty Is the Best Policy: an Empirical Study of the Role of Truth in No-Trial Medical Dispute Resolution in Taiwan

  Liang, C.

  11/1/15 → 10/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Synthesis of Submicron- and Nano-Plastics and Their Applications on the Detection of Plastic Particle-Containing Seafoods and Toxicological Studies

  Hsiao, I.

  9/1/19 → 8/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 奈米塑膠微粒於消化液與血清中之物化特性分析與其對小鼠腸道發炎及組織分布影響之研究(1/3)

  Hsiao, I.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Islide - a Global Community E-Learning Online

  Li, Y. & Jian, W.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Syntheses of Anti-Lung Cancer Agents(1/2)

  Liou, J.

  6/1/17 → 5/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dementia Care and Quality Improvement

  Chien, L., Chiou, H., Chi, N. & Hu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以重要性－績效分析法探討床邊資訊系統之研究

  Wen, H.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluation of the Discriminative Ability of Multiple Comorbidity Indices

  Huang, K.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of Content of Identity and Identification--The Interplay of Individual and Organizational Level

  Chiu, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Explore the Critical Factors for Physicians Using Mobile Health by Information Systems Success Model.

  Wen, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Regioselective Substitution on 1,4-Benzoquinone Derivatives to Provide Potent Anticancer Agents

  Liou, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• An Action Research Approach to Clinical Skills Education Development : Using Reflective Writing to Promote the Transformation of Students’ Skill Acquisition toward the Way of Better-Best-Practice

  Lin, W., Chen, C. & Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• Roles of Toll-Like Receptor-4 and Hif-1 in Propofol-Involved Protection against Traumatic Brain Injury-Induced Dysfunction of the Blood-Brain Barrier

  Chen, R.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Adaptation of Multi-Source Appraisal of Medical Professionalism among Medical Students and Their Socialization Process.

  Chiu, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Subproject 2---Establishment of a General Multi-Input Multi-Output Platform for Assistive Technology Followed by Developing Individual-Specific Systems: for the Quadriplegic (Themes: E1)

  Chen, S., Peng, C., Pan, L., Jian, W. & Liou, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Relevance of Financial Literacy and Fintech Service Demand

  Hsiao, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 臨界點理論在醫師專業認同發展歷程的應用--成為好醫師路上的轉化歷程(1/2)

  Chiu, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology