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慢性肝病在台灣是一個極具挑戰性的臨床議題。肝纖維化的多重病原性是造成病患死亡 率增加的原因,而且肝纖維化往往會發展成肝癌。我們最近利用國民營養調查資料庫 (NAHSIT 2005-2008)分析國人血中鐵營養值標與代謝症候群的相關性.在全人口的分析 中,我們發現校正了血清發炎指標以及飲食的營養指標後, serum ferritin (鐵蛋白質) 高於最大三等分位的族群,得到代謝性症候群的危險對比值超過 1.6 倍. 目前並不清楚 過量的鐵蛋白質為何與代謝症候群的發生率有關。肝臟為重要的儲鐵器官但是臨床研究 也顯示過量的鐵質沉積與肝纖維化及肝癌有極大的相關性。血清中鐵蛋白質為反映體內 儲存鐵的生化質標。但是,發炎因子也會造成血清中鐵蛋白質的異常增加。證據顯示發炎 因子可以調控鐵蛋白質的基因表現量。但是慢性發炎如何造成鐵蛋白質代謝異常(組職 內沉積及釋放)? 血清中的鐵蛋白質又有何生理功能? 隨著國人代謝症候群及脂肪肝發生率的年輕化,這次研究的主題是以老鼠初代星狀肝細 胞來分析鐵蛋白質對內質網壓力機轉與肝纖維化的影響: 相關研究的主要目標為: 1. 釐清鐵蛋白質(serum ferritin)過量是否會造成星狀細胞內質網壓力增加與活化? 2. 何種鐵質(ferric, ferrous, ferritin, Apoferritin)較易增加內質網壓力? 3. 找出何種內質網壓力的轉錄因子 (ATF6,ATF4, XBP1 and CHOP)受到鐵質調控? 4. 分析鐵質誘導的內質網壓力機轉與肝臟纖維化的營響

Chang, J.

9/1/128/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

生命期營養單張-更年期營養單張

Yang, S.

8/20/1212/31/12

Project: A - Government Institutionc - Ministry of Health and Welfare

行政院衛生署所屬醫院101年度滿意度調查評估採購案

Kuo, N.

8/6/1211/15/12

Project: A - Government Institutionf - Other (Funded by Government)

The Influence of Porphyromonas Gingivalis Groel in Vascular Cells

Lin, F.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Studies on the Carcinogenic Mechanisms of Histamine N-Methyltransferase-Mediated Breast Cancer Formation

Wu, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Chinese Herbal Compound Extract of Pig Sperm Detection and Activation of the Pharmacokinetic Evaluation and Preparation of R &Amp; D

Lee, C.

8/1/123/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of Microrna Let-7g in Cytosolic Ca2+ Regulation and Cox-2 Gene Expression

Chang, W.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Studies the Function and Mechanism of Dnaja3a/Dnaja3b and Interaction Molecules during the Embryonic Satges

Chow, J.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Effect of Pacemaker Current Inhibitor (Ivabradine) on Sinoatrial Node Function and Pulmonary Vein Arrhythmogenesis

Lin, Y.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Pharmaceuticals Removal in Hospital Wastwater and Effluent by Electro-Coagulation-Flotation

Hu, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of Fish Oil on Alcoholic Liver Disease in Rats Based on Pathological Mechanisms

Yang, S.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Studies of Cxcl12 in Hypoxia-Induced Pulmonary Fibrosis

Chen, B.

8/1/1210/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Therapeutic Evaluation Etanercept, a Tumor Necrosis Factor Antagonist, in Experimental Heatstroke

Chang, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Enhancement of Immuno-Modulatory Capacity by Shear Stress in Mesenchymal Stem Cells

Ho, J.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of DDX3 in Human Papillomavirus-Infected Lung Tumorigenesis

Lee, H.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Application of Diffusion Tensor Imaging to Study the White Matter Integrity and Coherence in Resting Electroencephalography

Shiu, R.

8/1/121/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Motorcyclist Behavioural Patterns to Pedestrian Green Signal Countdown Device (Pgscd): a Mixed Logit Analysis

Pai, C.

8/1/129/30/13

Project: A - Government Institutionb - Ministry of Science and Technology

In vitro and in vivo Evaluation for Silk Fibroin-Coated Electrospun Resorbable Poly(Lactic Acid) GTR Barriers

Yang, J.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Bullying Experience, Attitude and Suicide Attempts among Adolescents

Chen, P.

8/1/127/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Targeting Hif-1α by Zebularine for the Treatment of Colorectal Cancers

Yang, P.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Community-Based Screening and Prevention Model for Periodontal Disease

Chen, L.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Integrative Studies on Falls, Osteoporosis, and Fractures in Older People

Lin, M.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Role of Er Stress in Evodiamine-Induced Apoptosis and G2/M Arrest of Human Colorectal Carcinoma Cells

Chen, Y.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Adaptation of Multi-Source Appraisal of Medical Professionalism among Medical Students and Their Socialization Process.

Chiu, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Reflex Pelvic Floor Muscle Activities in Women with Urinary Incontinence (Ii)

Yang, J.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Oral Health and Interventions for Elderly in Long-Term Care Facilities

Chang, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Functional Role of Transcription Factor Sp1 in Brain Neuronal Injury( I )

Chang, W.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Exploring the Effects of an Exercise Program on Female Diabetic Patients' Health

Liao, Y.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of Cd69 in Tnfalpha-Inhibited Erythroid Differentiation

Huang, H.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

轉錄因子Sp1在腦神經損傷所扮演隻角色(1/3)

Chang, W.

8/1/127/31/13

Project: B - Project of TMUi - Other (Funded by TMU)

The Effects of Music Therapy on Psychological Distress and Functional Recovery in Patients with Stroke

Chang, H.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Exploitation of Taiwan Native Plants in Promoting Bone Growth and Establishment of the System Biology Platform

Lee, M.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Studies on the Mechanism of Intravenous Immunoglobulin (Ivig)-Induced Inhibitory Functions on Neutrophil Recruitments

Chang, J.

8/1/127/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Real-Time Single-Cell Probing of the Spatiotemporal Regulation of Cancer Cell Chemotaxis Using Nano-Scale Biomedicaltechnologies

Yang, T.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Study the Klf10 Alters Metabolic Pathways in Genetic-Deficient Mice and Human Pancreatic Ductal Carcinomas

Chang, H.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Molecular Mechanisms of Propofol-Involved Protection against Ischemia Brain Injuries

Chen, T.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Studies of Cxcl12 in Hypoxia-Induced Pulmonary Fibrosis

Chen, B. & Chung, C.

8/1/127/31/13

Project: B - Project of TMUi - Other (Funded by TMU)

Molecular Mechanisms Underlying Statins-Suppressed Colorectal Cancer Progression: Role of P53 Family Proteins and Microrna

Hsu, M.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Endothelin-1 Mediates Fibrocyte Differentiation in Chronic Obstructive Asthma

Lin, C.

8/1/1210/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Genomic and Non-Genomic Estrogen Effects on the Spinal Nr2b-Related Uterus-Colon Crosstalk in Rats

Lin, T.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

A Study on the Evaluation of Stromal Stem Cells and Stromal Fibroblasts in Human Tissue Regenerative and Cancer Forming Potentials

Shih, T.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Study on the Immuno-Modulatory Effects of Notch Ligand Delta 4 on Immune Cells and in Ova-Induced Asthmatic Mice

Lee, Y.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Effects of Atherosclerosis Progression in Circulating Ferritin in Community-Based Population

Bai, C.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Therapeutic Strategies for Traumatic Brain Injury with Novelly Desinged Drugs( I )

Wang, J.

8/1/127/31/14

Project: B - Project of TMUi - Other (Funded by TMU)