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慢性肝病在台灣是一個極具挑戰性的臨床議題。肝纖維化的多重病原性是造成病患死亡 率增加的原因，而且肝纖維化往往會發展成肝癌。我們最近利用國民營養調查資料庫 (NAHSIT 2005-2008)分析國人血中鐵營養值標與代謝症候群的相關性.在全人口的分析 中，我們發現校正了血清發炎指標以及飲食的營養指標後, serum ferritin (鐵蛋白質) 高於最大三等分位的族群，得到代謝性症候群的危險對比值超過 1.6 倍. 目前並不清楚 過量的鐵蛋白質為何與代謝症候群的發生率有關。肝臟為重要的儲鐵器官但是臨床研究 也顯示過量的鐵質沉積與肝纖維化及肝癌有極大的相關性。血清中鐵蛋白質為反映體內 儲存鐵的生化質標。但是,發炎因子也會造成血清中鐵蛋白質的異常增加。證據顯示發炎 因子可以調控鐵蛋白質的基因表現量。但是慢性發炎如何造成鐵蛋白質代謝異常(組職 內沉積及釋放)? 血清中的鐵蛋白質又有何生理功能? 隨著國人代謝症候群及脂肪肝發生率的年輕化,這次研究的主題是以老鼠初代星狀肝細 胞來分析鐵蛋白質對內質網壓力機轉與肝纖維化的影響: 相關研究的主要目標為: 1. 釐清鐵蛋白質(serum ferritin)過量是否會造成星狀細胞內質網壓力增加與活化? 2. 何種鐵質(ferric, ferrous, ferritin, Apoferritin)較易增加內質網壓力? 3. 找出何種內質網壓力的轉錄因子 (ATF6,ATF4, XBP1 and CHOP)受到鐵質調控? 4. 分析鐵質誘導的內質網壓力機轉與肝臟纖維化的營響
9/1/12 → 8/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
生命期營養單張-更年期營養單張
8/20/12 → 12/31/12
Project: A - Government Institution › c - Ministry of Health and Welfare
行政院衛生署所屬醫院101年度滿意度調查評估採購案
8/6/12 → 11/15/12
Project: A - Government Institution › f - Other (Funded by Government)
The Influence of Porphyromonas Gingivalis Groel in Vascular Cells
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Studies on the Carcinogenic Mechanisms of Histamine N-Methyltransferase-Mediated Breast Cancer Formation
Wu, C.
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Chinese Herbal Compound Extract of Pig Sperm Detection and Activation of the Pharmacokinetic Evaluation and Preparation of R &Amp; D
8/1/12 → 3/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
The Role of Microrna Let-7g in Cytosolic Ca2+ Regulation and Cox-2 Gene Expression
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Studies the Function and Mechanism of Dnaja3a/Dnaja3b and Interaction Molecules during the Embryonic Satges
Chow, J.
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Effect of Pacemaker Current Inhibitor (Ivabradine) on Sinoatrial Node Function and Pulmonary Vein Arrhythmogenesis
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Pharmaceuticals Removal in Hospital Wastwater and Effluent by Electro-Coagulation-Flotation
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Effects of Fish Oil on Alcoholic Liver Disease in Rats Based on Pathological Mechanisms
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Studies of Cxcl12 in Hypoxia-Induced Pulmonary Fibrosis
8/1/12 → 10/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
The Study of the Relationships among Anti-Obesity Activity, Adipogenesis, and Adipose Angiogenesis of Vegetable Indolic Derivatives – Involvement of the Ah Receptor/Arnt ?
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Therapeutic Evaluation Etanercept, a Tumor Necrosis Factor Antagonist, in Experimental Heatstroke
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Enhancement of Immuno-Modulatory Capacity by Shear Stress in Mesenchymal Stem Cells
Ho, J.
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
The Role of DDX3 in Human Papillomavirus-Infected Lung Tumorigenesis
Lee, H.
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Application of Diffusion Tensor Imaging to Study the White Matter Integrity and Coherence in Resting Electroencephalography
Shiu, R.
8/1/12 → 1/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Motorcyclist Behavioural Patterns to Pedestrian Green Signal Countdown Device (Pgscd): a Mixed Logit Analysis
8/1/12 → 9/30/13
Project: A - Government Institution › b - Ministry of Science and Technology
In vitro and in vivo Evaluation for Silk Fibroin-Coated Electrospun Resorbable Poly(Lactic Acid) GTR Barriers
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Bullying Experience, Attitude and Suicide Attempts among Adolescents
8/1/12 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Targeting Hif-1α by Zebularine for the Treatment of Colorectal Cancers
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Community-Based Screening and Prevention Model for Periodontal Disease
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Integrative Studies on Falls, Osteoporosis, and Fractures in Older People
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Role of Er Stress in Evodiamine-Induced Apoptosis and G2/M Arrest of Human Colorectal Carcinoma Cells
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Adaptation of Multi-Source Appraisal of Medical Professionalism among Medical Students and Their Socialization Process.
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Reflex Pelvic Floor Muscle Activities in Women with Urinary Incontinence (Ii)
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Oral Health and Interventions for Elderly in Long-Term Care Facilities
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Functional Role of Transcription Factor Sp1 in Brain Neuronal Injury( I )
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Exploring the Effects of an Exercise Program on Female Diabetic Patients' Health
Liao, Y.
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
The Role of Cd69 in Tnfalpha-Inhibited Erythroid Differentiation
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
The Effects of Music Therapy on Psychological Distress and Functional Recovery in Patients with Stroke
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
The Exploitation of Taiwan Native Plants in Promoting Bone Growth and Establishment of the System Biology Platform
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
The Studies on the Mechanism of Intravenous Immunoglobulin (Ivig)-Induced Inhibitory Functions on Neutrophil Recruitments
8/1/12 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
Real-Time Single-Cell Probing of the Spatiotemporal Regulation of Cancer Cell Chemotaxis Using Nano-Scale Biomedicaltechnologies
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Research and Development of Multi-Purpose Microtube Array (Mta) Membrane: Applications Identification through Materials Selection and Development of Prototype Production Unit via Fabrication Process Optimization
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Characterizationof Platelet-Rich Fibrin Releasing Growth Factors and Its Application on Regeneration of Nerve Injury during Radical Prostatectomy
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Roles of Toll-Like Receptor-4 and Hif-1 in Propofol-Involved Protection against Traumatic Brain Injury-Induced Dysfunction of the Blood-Brain Barrier
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Study the Klf10 Alters Metabolic Pathways in Genetic-Deficient Mice and Human Pancreatic Ductal Carcinomas
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Molecular Mechanisms of Propofol-Involved Protection against Ischemia Brain Injuries
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Studies of Cxcl12 in Hypoxia-Induced Pulmonary Fibrosis
8/1/12 → 7/31/13
Project: B - Project of TMU › i - Other (Funded by TMU)
Molecular Mechanisms Underlying Statins-Suppressed Colorectal Cancer Progression: Role of P53 Family Proteins and Microrna
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Endothelin-1 Mediates Fibrocyte Differentiation in Chronic Obstructive Asthma
8/1/12 → 10/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Novel Activities of Gamma-Aminobutyric Acid-Mediated Regulation of Platelet Activation, Apoptosis, and Autophagy: the Non-Genomic Functions of Nf-Kappab Signal in Anucleated Cells
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Genomic and Non-Genomic Estrogen Effects on the Spinal Nr2b-Related Uterus-Colon Crosstalk in Rats
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
A Study on the Evaluation of Stromal Stem Cells and Stromal Fibroblasts in Human Tissue Regenerative and Cancer Forming Potentials
Shih, T.
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Study on the Immuno-Modulatory Effects of Notch Ligand Delta 4 on Immune Cells and in Ova-Induced Asthmatic Mice
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
The Effects of Atherosclerosis Progression in Circulating Ferritin in Community-Based Population
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Characterization of Molecular and Pathological Role of Hs 1-Associated Protein X-1(Hax-1) in Cisplatin Induced Nephorotoxicity via Hax-1 Conditional Knock out Mice
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
Therapeutic Strategies for Traumatic Brain Injury with Novelly Desinged Drugs( I )
8/1/12 → 7/31/14
Project: B - Project of TMU › i - Other (Funded by TMU)